Ro60 Ro60, Y RNA binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ro60provided by RGD
Official Full Name: Ro60, Y RNA binding proteinprovided by RGD
Primary source: RGD:1305083
See related: EnsemblRapid:ENSRNOG00000003434 AllianceGenome:RGD:1305083
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ssa2; Trove2
Summary: Predicted to enable U2 snRNA binding activity. Predicted to be involved in cellular response to interferon-alpha and regulation of gene expression. Predicted to act upstream of or within several processes, including cilium assembly; response to UV; and smoothened signaling pathway. Predicted to be located in cytosol and nuclear body. Predicted to be part of ribonucleoprotein complex. Orthologous to human RO60 (Ro60, Y RNA binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 230.5), Heart (RPKM 221.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (58049838..58070828, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (55499514..55520504, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (60546892..60567882, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH143907 (e-PCR)
- UniSTS:233153

RH143150 (e-PCR)
- UniSTS:232397

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables U2 snRNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to interferon-alpha	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system development	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to UV	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RNA-binding protein RO60

Names: 60 kDa SS-A/Ro ribonucleoprotein; Sjogren syndrome antigen A2; TROVE domain family, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107183.1 → NP_001100653.1 RNA-binding protein RO60

See identical proteins and their annotated locations for NP_001100653.1

Status: PROVISIONAL

Source sequence(s)

CH473958

UniProtKB/TrEMBL

A0A8I5ZM47, A6ICP3, D3ZRN5

Related

ENSRNOP00000004701.4, ENSRNOT00000004701.9

Conserved Domains (2) summary

cd00198
Location:372 → 489

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

pfam05731
Location:16 → 369

TROVE; TROVE domain