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    Dtwd2 DTW domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361326, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dtwd2provided by RGD
    Official Full Name
    DTW domain containing 2provided by RGD
    Primary source
    RGD:1306423
    See related
    EnsemblRapid:ENSRNOG00000059142 AllianceGenome:RGD:1306423
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306423
    Summary
    Predicted to enable tRNA-uridine aminocarboxypropyltransferase activity. Predicted to be involved in tRNA modification. Predicted to be located in cytoplasm and nucleus. Orthologous to human DTWD2 (DTW domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 35.5), Muscle (RPKM 34.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dtwd2 in Genome Data Viewer
    Location:
    18q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (45003242..45088595, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (42811783..42902040, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (43857371..43945732, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098276 Neighboring gene high-mobility group box 1, pseudogene 22 Neighboring gene tripartite motif-containing 28 protein-like Neighboring gene uncharacterized LOC120098148 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ribosomal protein L15, pseudogene 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biogenesis and functions of aminocarboxypropyluridine in tRNA. Takakura M, et al. Nat Commun, 2019 Dec 5. PMID 31804502, Free PMC Article
    2. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Hasson SA, et al. Nature, 2013 Dec 12. PMID 24270810, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tRNA-uridine aminocarboxypropyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-uridine aminocarboxypropyltransferase 2
    Names
    DTW domain-containing protein 2
    NP_001101901.1
    XP_006251070.1
    XP_038952897.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108431.1 → NP_001101901.1  tRNA-uridine aminocarboxypropyltransferase 2

      See identical proteins and their annotated locations for NP_001101901.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473971
      UniProtKB/TrEMBL
      A6IWZ4, D3ZGK2
      Related
      ENSRNOP00000075130.3, ENSRNOT00000088900.3
      Conserved Domains (1) summary
      pfam03942
      Location:66 → 256
      DTW; DTW domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      45003242..45088595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096969.2 → XP_038952897.1  tRNA-uridine aminocarboxypropyltransferase 2 isoform X2

      UniProtKB/TrEMBL
      A6IWZ5
      Conserved Domains (1) summary
      cl01221
      Location:66 → 142
      DTW; DTW domain

    2. XM_006251008.4 → XP_006251070.1  tRNA-uridine aminocarboxypropyltransferase 2 isoform X1

      UniProtKB/TrEMBL
      D3ZGK2
      Conserved Domains (1) summary
      pfam03942
      Location:66 → 198
      DTW; DTW domain

    RNA

    1. XR_005496050.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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