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    Icam2 intercellular adhesion molecule 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360647, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Icam2provided by RGD
    Official Full Name
    intercellular adhesion molecule 2provided by RGD
    Primary source
    RGD:1359660
    See related
    EnsemblRapid:ENSRNOG00000025143 AllianceGenome:RGD:1359660
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable integrin binding activity. Predicted to be involved in cell adhesion. Predicted to be located in cleavage furrow; microvillus; and uropod. Predicted to be active in plasma membrane. Orthologous to human ICAM2 (intercellular adhesion molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 320.7), Thymus (RPKM 258.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Icam2 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (91808449..91819319, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (91308608..91319536, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94569889..94581218, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene CD79b molecule Neighboring gene sodium voltage-gated channel alpha subunit 4 Neighboring gene uncharacterized LOC108352146 Neighboring gene proline rich 29 Neighboring gene endoplasmic reticulum to nucleus signaling 1 Neighboring gene ribosomal protein S10, pseudogene 6 Neighboring gene uncharacterized LOC102546698 Neighboring gene small nucleolar RNA, C/D box 104

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ICAM-2 and lipid rafts disappear from the basal plasma membrane of uterine epithelial cells during early pregnancy in rats. Lecce L, et al. Cell Tissue Res, 2013 Sep. PMID 23736379
    2. Intercellular adhesion molecule-2 is involved in apical ectoplasmic specialization dynamics during spermatogenesis in the rat. Xiao X, et al. J Endocrinol, 2013 Jan. PMID 23097088, Free PMC Article
    3. Isolation, characterization, and expression of mouse ICAM-2 complementary and genomic DNA. Xu H, et al. J Immunol, 1992 Oct 15. PMID 1401904
    4. Overlapping and selective roles of endothelial intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 in lymphocyte trafficking. Lehmann JC, et al. J Immunol, 2003 Sep 1. PMID 12928410
    5. Polar redistribution of the sialoglycoprotein CD43: implications for T cell function. Savage ND, et al. J Immunol, 2002 Apr 15. PMID 11937524

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95023

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in uropod ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    intercellular adhesion molecule 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007725.1 → NP_001007726.1  intercellular adhesion molecule 2 precursor

      See identical proteins and their annotated locations for NP_001007726.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079465
      UniProtKB/TrEMBL
      F7F7V6, Q6AXM6
      Related
      ENSRNOP00000034319.3, ENSRNOT00000035474.5
      Conserved Domains (2) summary
      pfam03921
      Location:24 → 111
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cl11960
      Location:114 → 205
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      91808449..91819319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269470.1 → XP_063125540.1  intercellular adhesion molecule 2 isoform X3

      UniProtKB/TrEMBL
      A6HK43

    2. XM_006247624.5 → XP_006247686.1  intercellular adhesion molecule 2 isoform X1

      See identical proteins and their annotated locations for XP_006247686.1

      UniProtKB/TrEMBL
      F7F7V6, Q6AXM6
      Conserved Domains (2) summary
      pfam03921
      Location:24 → 111
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cl11960
      Location:114 → 205
      Ig; Immunoglobulin domain

    3. XM_006247627.5 → XP_006247689.1  intercellular adhesion molecule 2 isoform X1

      See identical proteins and their annotated locations for XP_006247689.1

      UniProtKB/TrEMBL
      F7F7V6, Q6AXM6
      Conserved Domains (2) summary
      pfam03921
      Location:24 → 111
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cl11960
      Location:114 → 205
      Ig; Immunoglobulin domain

    4. XM_063269464.1 → XP_063125534.1  intercellular adhesion molecule 2 isoform X1

      UniProtKB/TrEMBL
      F7F7V6, Q6AXM6

    5. XM_063269466.1 → XP_063125536.1  intercellular adhesion molecule 2 isoform X1

      UniProtKB/TrEMBL
      F7F7V6, Q6AXM6

    6. XM_008768379.4 → XP_008766601.1  intercellular adhesion molecule 2 isoform X1

      See identical proteins and their annotated locations for XP_008766601.1

      UniProtKB/TrEMBL
      F7F7V6, Q6AXM6
      Conserved Domains (2) summary
      pfam03921
      Location:24 → 111
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cl11960
      Location:114 → 205
      Ig; Immunoglobulin domain

    7. XM_063269465.1 → XP_063125535.1  intercellular adhesion molecule 2 isoform X1

      UniProtKB/TrEMBL
      F7F7V6, Q6AXM6

    8. XM_063269467.1 → XP_063125537.1  intercellular adhesion molecule 2 isoform X1

      UniProtKB/TrEMBL
      F7F7V6, Q6AXM6

    9. XM_063269463.1 → XP_063125533.1  intercellular adhesion molecule 2 isoform X1

      UniProtKB/TrEMBL
      F7F7V6, Q6AXM6

    10. XM_063269469.1 → XP_063125539.1  intercellular adhesion molecule 2 isoform X1

      UniProtKB/TrEMBL
      F7F7V6, Q6AXM6

    11. XM_063269468.1 → XP_063125538.1  intercellular adhesion molecule 2 isoform X1

      UniProtKB/TrEMBL
      F7F7V6, Q6AXM6

    12. XM_039086420.2 → XP_038942348.1  intercellular adhesion molecule 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZNQ0
      Related
      ENSRNOP00000079806.1, ENSRNOT00000115213.2
      Conserved Domains (3) summary
      cd00096
      Location:113 → 120
      Ig; Ig strand A [structural motif]
      cd20995
      Location:27 → 111
      IgI_N_ICAM-2; N-terminal immunoglobulin domain of the intercellular adhesion molecules ICAM-2 (Cluster of Differentiation 102 or CD102); member of the I-set of IgSF domains
      cl11960
      Location:113 → 210
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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