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    Bnip2 BCL2 interacting protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300811, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Bnip2provided by RGD
    Official Full Name
    BCL2 interacting protein 2provided by RGD
    Primary source
    RGD:1308944
    See related
    EnsemblRapid:ENSRNOG00000056024 AllianceGenome:RGD:1308944
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in response to oxygen-glucose deprivation. Predicted to be located in cytosol; microtubule organizing center; and nucleus. Predicted to be active in cytoplasm. Orthologous to human BNIP2 (BCL2 interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 206.7), Heart (RPKM 171.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bnip2 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (79521375..79539148)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (70640436..70661782)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (76400333..76426307)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS10-like Neighboring gene uncharacterized LOC120094198 Neighboring gene general transcription factor 2A subunit 2 Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential expression of BNIP family members of BH3-only proteins during the development and after axotomy in the rat. Cho B, et al. Mol Cells, 2012 Jun. PMID 22639046, Free PMC Article
    2. Nip2/centrobin may be a substrate of Nek2 that is required for proper spindle assembly during mitosis in early mouse embryos. Sonn S, et al. Mol Reprod Dev, 2009 Jun. PMID 19117032
    3. Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway. Oh JE, et al. FASEB J, 2009 Jul. PMID 19244314, Free PMC Article
    4. N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts. Lu M, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20160094, Free PMC Article
    5. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. Boyd JM, et al. Cell, 1994 Oct 21. PMID 7954800

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within blastocyst development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxygen-glucose deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within striated muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
    Names
    BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP2
    BCL2/adenovirus E1B interacting protein 2
    Bcl-2 and E1B 19 kDa interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106835.1 → NP_001100305.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

      See identical proteins and their annotated locations for NP_001100305.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474041
      UniProtKB/TrEMBL
      A0A8I6AVU1, A6KEV4
      Conserved Domains (2) summary
      cd00170
      Location:147 → 290
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      pfam12496
      Location:49 → 163
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      79521375..79539148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243370.5 → XP_006243432.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006243432.1

      UniProtKB/TrEMBL
      A0A0G2K1P3, A6KEV3, D3ZGE0
      Related
      ENSRNOP00000070548.2, ENSRNOT00000081072.3
      Conserved Domains (2) summary
      cd00170
      Location:147 → 290
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      pfam12496
      Location:49 → 163
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2

    2. XM_006243371.5 → XP_006243433.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006243433.1

      UniProtKB/TrEMBL
      A0A8I6AVU1, A6KEV2
      Related
      ENSRNOP00000096973.2, ENSRNOT00000102436.2
      Conserved Domains (2) summary
      cd00170
      Location:147 → 290
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      pfam12496
      Location:49 → 163
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    Nucleotide Protein Strain
    Heading Accession and Version

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