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    Mtus2 microtubule associated scaffold protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498136, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtus2provided by RGD
    Official Full Name
    microtubule associated scaffold protein 2provided by RGD
    Primary source
    RGD:1562533
    See related
    EnsemblRapid:ENSRNOG00000032410 AllianceGenome:RGD:1562533
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562533
    Summary
    Predicted to enable microtubule binding activity and protein homodimerization activity. Predicted to be located in centrosome; cytoplasmic microtubule; and intercellular bridge. Predicted to be active in nucleus. Predicted to colocalize with cytoplasm. Orthologous to human MTUS2 (microtubule associated scaffold protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 139.0), Brain (RPKM 38.5) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtus2 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (11742713..12115798, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (6706531..7078331, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (8111655..8491553, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A, pseudogene 3 Neighboring gene solute carrier family 7 member 1 Neighboring gene uncharacterized LOC102547400 Neighboring gene uncharacterized LOC134481259 Neighboring gene U2 spliceosomal RNA Neighboring gene solute carrier family 46, member 3 Neighboring gene proteasome maturation protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CAZIP, a novel protein expressed in the developing heart and nervous system. Du Puy L, et al. Dev Dyn, 2009 Nov. PMID 19806667
    2. TIP150 interacts with and targets MCAK at the microtubule plus ends. Jiang K, et al. EMBO Rep, 2009 Aug. PMID 19543227, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated tumor suppressor candidate 2
    Names
    microtubule associated tumor suppressor candidate 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100989.3 → NP_001094459.2  microtubule-associated tumor suppressor candidate 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8J8YSZ5, A0JPQ3, F1LNR5
      Related
      ENSRNOP00000060535.3, ENSRNOT00000064721.4
      Conserved Domains (2) summary
      COG0419
      Location:22 → 285
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:155 → 279
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_001374100.2 → NP_001361029.1  microtubule-associated tumor suppressor candidate 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A0G2K4U7
      Conserved Domains (2) summary
      PHA03247
      Location:624 → 1007
      PHA03247; large tegument protein UL36; Provisional
      COG0419
      Location:1021 → 1310
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      11742713..12115798 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598434.3 → XP_017453923.1  microtubule-associated tumor suppressor candidate 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4U7
      Conserved Domains (2) summary
      PHA03247
      Location:624 → 1007
      PHA03247; large tegument protein UL36; Provisional
      COG0419
      Location:1021 → 1310
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

    2. XM_039089680.2 → XP_038945608.1  microtubule-associated tumor suppressor candidate 2 isoform X3

      Conserved Domains (2) summary
      PHA03247
      Location:13 → 220
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:183 → 487
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_039089681.2 → XP_038945609.1  microtubule-associated tumor suppressor candidate 2 isoform X4

      Conserved Domains (1) summary
      TIGR02168
      Location:57 → 361
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_039089682.2 → XP_038945610.1  microtubule-associated tumor suppressor candidate 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AJM3, A6K190
      Related
      ENSRNOP00000093232.1, ENSRNOT00000104730.2
      Conserved Domains (2) summary
      COG0419
      Location:22 → 318
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      PRK11281
      Location:168 → 315
      PRK11281; mechanosensitive channel MscK

    5. XM_039089678.2 → XP_038945606.1  microtubule-associated tumor suppressor candidate 2 isoform X2

      Conserved Domains (1) summary
      PHA03247
      Location:729 → 993
      PHA03247; large tegument protein UL36; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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