Itih3 inter-alpha trypsin inhibitor, heavy chain 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itih3provided by RGD
Official Full Name: inter-alpha trypsin inhibitor, heavy chain 3provided by RGD
Primary source: RGD:620633
See related: EnsemblRapid:ENSRNOG00000017689 AllianceGenome:RGD:620633
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PAIHC3
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in hyaluronan metabolic process and negative regulation of peptidase activity. Predicted to be located in extracellular region. Orthologous to human ITIH3 (inter-alpha-trypsin inhibitor heavy chain 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 11567.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 16p16

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (6108378..6123609, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (6101922..6117154, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (6983779..7007288, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intracellular coupling of the heavy chain of pre-alpha-inhibitor to chondroitin sulfate
Title: Intracellular coupling of the heavy chain of pre-alpha-inhibitor to chondroitin sulfate.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130520 (e-PCR)
- UniSTS:213804

AW108094 (e-PCR)
- UniSTS:180627

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in hyaluronan metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: inter-alpha-trypsin inhibitor heavy chain H3

Names: ITI heavy chain H3; ITI-HC3; inter-alpha-inhibitor heavy chain 3; pre-alpha-inhibitor, heavy chain 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017351.1 → NP_059047.1 inter-alpha-trypsin inhibitor heavy chain H3 precursor

See identical proteins and their annotated locations for NP_059047.1

Status: PROVISIONAL

Source sequence(s)

X83231

UniProtKB/Swiss-Prot

Q63416

UniProtKB/TrEMBL

A6KG20

Related

ENSRNOP00000023984.4, ENSRNOT00000023984.8

Conserved Domains (4) summary

smart00609
Location:29 → 158

VIT; Vault protein Inter-alpha-Trypsin domain

TIGR03788
Location:47 → 602

marine_srt_targ; marine proteobacterial sortase target protein

pfam06668
Location:681 → 868

ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

cl00057
Location:281 → 462

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...