Asxl1 ASXL transcriptional regulator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Asxl1provided by RGD
Official Full Name: ASXL transcriptional regulator 1provided by RGD
Primary source: RGD:1561878
See related: EnsemblRapid:ENSRNOG00000061603 AllianceGenome:RGD:1561878
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561878
Summary: Predicted to enable nuclear retinoic acid receptor binding activity; peroxisome proliferator activated receptor binding activity; and transcription coactivator activity. Involved in negative regulation of lipid storage. Predicted to be located in nucleus. Predicted to be part of PR-DUB complex. Human ortholog(s) of this gene implicated in SM-AHNMD; acute myeloid leukemia; chronic myelomonocytic leukemia; myelodysplastic syndrome; and myelofibrosis. Orthologous to human ASXL1 (ASXL transcriptional regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 99.1), Thymus (RPKM 99.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (162273828..162341742)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (141814012..141881526)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (148832231..148902356)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overall, these results support the reciprocal role of the ASXL family in lipid homeostasis through the opposite regulation of LXRalpha.
Title: Reciprocal regulation of LXRα activity by ASXL1 and ASXL2 in lipogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

RH138075 (e-PCR)
- UniSTS:220162

AI136740 (e-PCR)
- UniSTS:261219

BE107504 (e-PCR)
- UniSTS:246903

RH92532 (e-PCR)
- UniSTS:84344

AW525550 (e-PCR)
- UniSTS:245158

RH134019 (e-PCR)
- UniSTS:217301

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear retinoic acid receptor binding	ISO Inferred from Sequence Orthology more info
enables peroxisome proliferator activated receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables peroxisome proliferator activated receptor binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone marrow development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic or lymphoid organ development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung saccule development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peroxisome proliferator activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in podocyte development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of kidney size	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thymus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of PR-DUB complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PR-DUB complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: polycomb group protein ASXL1

Names: additional sex combs like 1, transcriptional regulator; additional sex combs like transcriptional regulator 1; putative Polycomb group protein ASXL1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.