Rnase2 ribonuclease A family member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnase2provided by RGD
Official Full Name: ribonuclease A family member 2provided by RGD
Primary source: RGD:1359432
See related: EnsemblRapid:ENSRNOG00000032133 AllianceGenome:RGD:1359432
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: R5; R14; R15; Ear4; Raf1
Summary: Predicted to enable RNA nuclease activity. Predicted to be involved in chemotaxis; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to be active in extracellular space. Orthologous to human RNASE2 (ribonuclease A family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 17.8), Thymus (RPKM 15.4) and 5 other tissues See more
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Genomic context

Location:: 15p14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (26923125..26923934, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (24449618..24450427, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (28154482..28155291, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH133047 (e-PCR)
- UniSTS:216330

D15Got28 (e-PCR)
- UniSTS:115574

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA nuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
NOT enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemotaxis	ISO Inferred from Sequence Orthology more info
NOT involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
NOT involved_in induction of bacterial agglutination	ISO Inferred from Sequence Orthology more info
involved_in innate immune response in mucosa	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ribonuclease A family member 2

Names: eosinophil-associated, ribonuclease A family, member 4; pre-eosinophil-associated ribonuclease-2; ribonuclease 14; ribonuclease 15; ribonuclease 5; ribonuclease A f1; ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)

NP_001007016.1

EC 4.6.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.