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    Tinf2 TERF1 interacting nuclear factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290232, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tinf2provided by RGD
    Official Full Name
    TERF1 interacting nuclear factor 2provided by RGD
    Primary source
    RGD:1359192
    See related
    EnsemblRapid:ENSRNOG00000020189 AllianceGenome:RGD:1359192
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable telomeric DNA binding activity. Predicted to be involved in several processes, including negative regulation of telomere maintenance via telomerase; protein localization to chromosome, telomeric region; and telomere organization. Predicted to act upstream of or within negative regulation of telomere maintenance. Predicted to be located in chromosome, telomeric region; nuclear body; and perinucleolar chromocenter. Predicted to be part of shelterin complex. Human ortholog(s) of this gene implicated in Revesz syndrome and autosomal dominant dyskeratosis congenita 3. Orthologous to human TINF2 (TERF1 interacting nuclear factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 108.6), Spleen (RPKM 101.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tinf2 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33140611..33146930, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29170663..29178015, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34358697..34365085, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene magnesium-dependent phosphatase 1 Neighboring gene NEDD8 ubiquitin like modifier Neighboring gene guanosine monophosphate reductase 2 Neighboring gene transglutaminase 1 Neighboring gene Rab geranylgeranyltransferase subunit alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2. Kaminker P, et al. J Cell Sci, 2005 Mar 15. PMID 15741234, Free PMC Article
    2. Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes. Kim SH, et al. J Cell Biol, 2008 May 5. PMID 18443218, Free PMC Article
    3. TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes. Walne AJ, et al. Blood, 2008 Nov 1. PMID 18669893, Free PMC Article
    4. Mus musculus and Mus spretus homologues of the human telomere-associated protein TIN2. Kim SH, et al. Genomics, 2003 Apr. PMID 12676566
    5. Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway. Chiang YJ, et al. Mol Cell Biol, 2004 Aug. PMID 15254230, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94711

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of telomere maintenance via telomere lengthening ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear telomere cap complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinucleolar chromocenter ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of shelterin complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TERF1-interacting nuclear factor 2
    Names
    TERF1 (TRF1)-interacting nuclear factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006962.1 → NP_001006963.1  TERF1-interacting nuclear factor 2

      See identical proteins and their annotated locations for NP_001006963.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083766
      UniProtKB/TrEMBL
      A6KH37, F7F4I8, Q5XIB8
      Related
      ENSRNOP00000027362.5, ENSRNOT00000027362.7
      Conserved Domains (2) summary
      cd11741
      Location:226 → 321
      TIN2_TBM; TRF-binding motif region of TRF-Interacting Nuclear factor 2
      pfam14973
      Location:20 → 153
      TINF2_N; TERF1-interacting nuclear factor 2 N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      33140611..33146930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251944.5 → XP_006252006.1  TERF1-interacting nuclear factor 2 isoform X5

      Conserved Domains (2) summary
      cd11741
      Location:226 → 321
      TIN2_TBM; TRF-binding motif region of TRF-Interacting Nuclear factor 2
      pfam14973
      Location:20 → 153
      TINF2_N; TERF1-interacting nuclear factor 2 N-terminus

    2. XM_006251943.5 → XP_006252005.1  TERF1-interacting nuclear factor 2 isoform X4

      Related
      ENSRNOP00000099026.1, ENSRNOT00000167823.1
      Conserved Domains (2) summary
      cd11741
      Location:226 → 321
      TIN2_TBM; TRF-binding motif region of TRF-Interacting Nuclear factor 2
      pfam14973
      Location:20 → 153
      TINF2_N; TERF1-interacting nuclear factor 2 N-terminus

    3. XM_006251942.5 → XP_006252004.1  TERF1-interacting nuclear factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZKC5
      Conserved Domains (2) summary
      cd11741
      Location:226 → 321
      TIN2_TBM; TRF-binding motif region of TRF-Interacting Nuclear factor 2
      pfam14973
      Location:20 → 153
      TINF2_N; TERF1-interacting nuclear factor 2 N-terminus

    4. XM_039093130.2 → XP_038949058.1  TERF1-interacting nuclear factor 2 isoform X2

      Related
      ENSRNOP00000077645.2, ENSRNOT00000110822.2
      Conserved Domains (3) summary
      PHA03247
      Location:188 → 392
      PHA03247; large tegument protein UL36; Provisional
      cd11741
      Location:226 → 321
      TIN2_TBM; TRF-binding motif region of TRF-Interacting Nuclear factor 2
      pfam14973
      Location:20 → 153
      TINF2_N; TERF1-interacting nuclear factor 2 N-terminus

    5. XM_063274126.1 → XP_063130196.1  TERF1-interacting nuclear factor 2 isoform X1

      Related
      ENSRNOP00000109835.1, ENSRNOT00000122224.1
    Nucleotide Protein Strain
    Heading Accession and Version

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