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    Pla2g4e phospholipase A2, group IVE [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296091, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pla2g4eprovided by RGD
    Official Full Name
    phospholipase A2, group IVEprovided by RGD
    Primary source
    RGD:1310595
    See related
    EnsemblRapid:ENSRNOG00000024904 AllianceGenome:RGD:1310595
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310595
    Summary
    Predicted to enable several functions, including calcium-dependent phospholipase A2 activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipid binding activity. Predicted to be involved in N-acylphosphatidylethanolamine metabolic process; glycerophospholipid catabolic process; and positive regulation of endocytic recycling. Predicted to be located in early endosome membrane; lysosomal membrane; and plasma membrane. Predicted to be active in cytosol. Orthologous to human PLA2G4E (phospholipase A2 group IVE). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 24.9), Testes (RPKM 20.1) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pla2g4e in Genome Data Viewer
    Location:
    3q35
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (127586318..127652369, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (107132540..107198609, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (111952396..112018470, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene phospholipase A2 group IVB Neighboring gene spectrin, beta, non-erythrocytic 5 Neighboring gene EH-domain containing 4 Neighboring gene phospholipase A2 group IVD Neighboring gene phospholipase A2, group IVF

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cytosolic phospholipase A₂ε drives recycling through the clathrin-independent endocytic route. Capestrano M, et al. J Cell Sci, 2014 Mar 1. PMID 24413173
    2. Phosphatidylserine-stimulated production of N-acyl-phosphatidylethanolamines by Ca(2+)-dependent N-acyltransferase. Hussain Z, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 May. PMID 29447909
    3. Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}. Ohto T, et al. J Biol Chem, 2005 Jul 1. PMID 15866882
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-independent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-5-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acylphosphatidylethanolamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycerophospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic phospholipase A2 epsilon
    Names
    phospholipase A2, group 4E
    XP_017447688.1
    XP_017447690.1
    XP_017447691.1
    XP_017447692.1
    XP_017447693.1
    XP_038962439.1
    XP_038962441.1
    XP_038962442.1
    XP_038962444.1
    XP_230487.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430038.1 → NP_001416967.1  cytosolic phospholipase A2 epsilon isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6ANS2, F1LPY6

    2. NM_001430039.1 → NP_001416968.1  cytosolic phospholipase A2 epsilon isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      F1LPY6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      127586318..127652369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_230487.10 → XP_230487.5  cytosolic phospholipase A2 epsilon isoform X2

      See identical proteins and their annotated locations for XP_230487.5

      UniProtKB/TrEMBL
      F1LPY6
      Related
      ENSRNOP00000031380.6, ENSRNOT00000030502.7
      Conserved Domains (3) summary
      cd04036
      Location:72 → 180
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      smart00022
      Location:314 → 801
      PLAc; Cytoplasmic phospholipase A2, catalytic subunit
      cl11396
      Location:318 → 860
      Patatin_and_cPLA2; Patatins and Phospholipases

    2. XM_017592204.3 → XP_017447693.1  cytosolic phospholipase A2 epsilon isoform X5

      Conserved Domains (3) summary
      pfam18695
      Location:133 → 240
      cPLA2_C2; Cytosolic phospholipases A2 C2-domain
      cl11396
      Location:239 → 781
      Patatin_and_cPLA2; Patatins and Phospholipases
      cl14603
      Location:1 → 101
      C2; C2 domain

    3. XM_017592202.3 → XP_017447691.1  cytosolic phospholipase A2 epsilon isoform X4

    4. XM_039106511.2 → XP_038962439.1  cytosolic phospholipase A2 epsilon isoform X3

      UniProtKB/TrEMBL
      A0A8I6AKA4, F1LPY6
      Conserved Domains (3) summary
      cd04036
      Location:58 → 166
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      pfam18695
      Location:198 → 305
      cPLA2_C2; Cytosolic phospholipases A2 C2-domain
      cl11396
      Location:304 → 846
      Patatin_and_cPLA2; Patatins and Phospholipases

    5. XM_017592199.3 → XP_017447688.1  cytosolic phospholipase A2 epsilon isoform X1

      UniProtKB/TrEMBL
      F1LPY6
      Related
      ENSRNOP00000093379.2, ENSRNOT00000097961.2
      Conserved Domains (3) summary
      cd04036
      Location:107 → 215
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      pfam18695
      Location:247 → 354
      cPLA2_C2; Cytosolic phospholipases A2 C2-domain
      cl11396
      Location:353 → 895
      Patatin_and_cPLA2; Patatins and Phospholipases

    6. XM_017592201.3 → XP_017447690.1  cytosolic phospholipase A2 epsilon isoform X4

      UniProtKB/TrEMBL
      A0A8I6ANS2, F1LPY6

    7. XM_017592203.2 → XP_017447692.1  cytosolic phospholipase A2 epsilon isoform X4

      UniProtKB/TrEMBL
      A0A8I6ANS2, F1LPY6
      Related
      ENSRNOP00000095683.1, ENSRNOT00000109239.2

    8. XM_039106513.2 → XP_038962441.1  cytosolic phospholipase A2 epsilon isoform X6

      Conserved Domains (3) summary
      cd04036
      Location:107 → 215
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      pfam18695
      Location:247 → 354
      cPLA2_C2; Cytosolic phospholipases A2 C2-domain
      cl11396
      Location:353 → 712
      Patatin_and_cPLA2; Patatins and Phospholipases

    9. XM_039106514.2 → XP_038962442.1  cytosolic phospholipase A2 epsilon isoform X7

      Conserved Domains (3) summary
      cd04036
      Location:107 → 215
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      pfam18695
      Location:247 → 354
      cPLA2_C2; Cytosolic phospholipases A2 C2-domain
      cl11396
      Location:353 → 554
      Patatin_and_cPLA2; Patatins and Phospholipases

    10. XM_039106516.2 → XP_038962444.1  cytosolic phospholipase A2 epsilon isoform X8

      Conserved Domains (3) summary
      cd04036
      Location:107 → 215
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      pfam18695
      Location:247 → 354
      cPLA2_C2; Cytosolic phospholipases A2 C2-domain
      cl11396
      Location:353 → 448
      Patatin_and_cPLA2; Patatins and Phospholipases
    Nucleotide Protein Strain
    Heading Accession and Version

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