Anks1a ankyrin repeat and sterile alpha motif domain containing 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Anks1aprovided by RGD
Official Full Name: ankyrin repeat and sterile alpha motif domain containing 1Aprovided by RGD
Primary source: RGD:1309183
See related: EnsemblRapid:ENSRNOG00000000498 AllianceGenome:RGD:1309183
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Anks1
Summary: Predicted to enable ephrin receptor binding activity. Predicted to be involved in ephrin receptor signaling pathway; neuron remodeling; and substrate-dependent cell migration. Predicted to act upstream of or within negative regulation of ubiquitin-dependent protein catabolic process and regulation of ephrin receptor signaling pathway. Predicted to be located in neuron projection and nucleoplasm. Predicted to be active in cytosol. Orthologous to human ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 100.7), Lung (RPKM 87.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (5965421..6118875)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (5963658..6117139)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (7484550..7636498)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH134403 (e-PCR)
- UniSTS:217685

AW529418 (e-PCR)
- UniSTS:261080

RH139847 (e-PCR)
- UniSTS:221931

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ephrin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in neuron remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in substrate-dependent cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ankyrin repeat and SAM domain-containing protein 1A

Names: ankyrin repeat and SAM domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107613.3 → NP_001101083.1 ankyrin repeat and SAM domain-containing protein 1A isoform 2

See identical proteins and their annotated locations for NP_001101083.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A6JJP3

Conserved Domains (7) summary

cd09499
Location:688 → 754

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:759 → 823

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

smart00454
Location:691 → 750

SAM; Sterile alpha motif

cd00204
Location:71 → 199

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01274
Location:917 → 1062

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

pfam12796
Location:183 → 274

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:77 → 107

ANK; ANK repeat [structural motif]
NM_001414943.1 → NP_001401872.1 ankyrin repeat and SAM domain-containing protein 1A isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

D4AC12

Related

ENSRNOP00000048981.4, ENSRNOT00000044395.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

5965421..6118875

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256193.5 → XP_006256255.1 ankyrin repeat and SAM domain-containing protein 1A isoform X1

UniProtKB/TrEMBL

A0A0G2K2G7

Conserved Domains (7) summary

cd09499
Location:712 → 778

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:783 → 847

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

smart00454
Location:715 → 774

SAM; Sterile alpha motif

cd00204
Location:71 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01274
Location:941 → 1086

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

pfam12796
Location:204 → 295

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:166 → 197

ANK; ANK repeat [structural motif]
XM_039098686.2 → XP_038954614.1 ankyrin repeat and SAM domain-containing protein 1A isoform X2

Related

ENSRNOP00000094383.2, ENSRNOT00000107130.2

Conserved Domains (6) summary

cd09499
Location:712 → 778

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:783 → 847

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

PHA03095
Location:67 → 302

PHA03095; ankyrin-like protein; Provisional

cd01274
Location:941 → 1086

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

sd00045
Location:166 → 197

ANK; ANK repeat [structural motif]

pfam12796
Location:204 → 295

Ank_2; Ankyrin repeats (3 copies)
XM_006256196.5 → XP_006256258.1 ankyrin repeat and SAM domain-containing protein 1A isoform X4

Conserved Domains (7) summary

cd09499
Location:712 → 778

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:783 → 847

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

smart00454
Location:715 → 774

SAM; Sterile alpha motif

cd00204
Location:71 → 220

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01274
Location:941 → 1086

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

pfam12796
Location:204 → 295

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:166 → 197

ANK; ANK repeat [structural motif]
XM_006256195.5 → XP_006256257.1 ankyrin repeat and SAM domain-containing protein 1A isoform X3

UniProtKB/TrEMBL

A0A8I6AJG9

Conserved Domains (7) summary

cd09499
Location:691 → 757

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:762 → 826

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

smart00454
Location:694 → 753

SAM; Sterile alpha motif

cd00204
Location:71 → 199

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01274
Location:920 → 1065

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

pfam12796
Location:183 → 274

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:77 → 107

ANK; ANK repeat [structural motif]
XM_006256197.5 → XP_006256259.1 ankyrin repeat and SAM domain-containing protein 1A isoform X5

Related

ENSRNOP00000108273.1, ENSRNOT00000152658.1

Conserved Domains (7) summary

cd09499
Location:691 → 757

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:762 → 826

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

smart00454
Location:694 → 753

SAM; Sterile alpha motif

cd00204
Location:71 → 199

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01274
Location:920 → 1065

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

pfam12796
Location:183 → 274

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:77 → 107

ANK; ANK repeat [structural motif]
XM_063279124.1 → XP_063135194.1 ankyrin repeat and SAM domain-containing protein 1A isoform X6

Related

ENSRNOP00000072237.3, ENSRNOT00000081604.3
XM_063279125.1 → XP_063135195.1 ankyrin repeat and SAM domain-containing protein 1A isoform X7
XM_063279126.1 → XP_063135196.1 ankyrin repeat and SAM domain-containing protein 1A isoform X8
XM_063279127.1 → XP_063135197.1 ankyrin repeat and SAM domain-containing protein 1A isoform X9