Lama5 laminin subunit alpha 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lama5provided by RGD
Official Full Name: laminin subunit alpha 5provided by RGD
Primary source: RGD:621023
See related: EnsemblRapid:ENSRNOG00000053691 AllianceGenome:RGD:621023
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable integrin binding activity. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in several processes, including axon guidance; integrin-mediated signaling pathway; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within several processes, including hair follicle development; morphogenesis of an epithelium; and trunk neural crest cell migration. Part of laminin-5 complex. Human ortholog(s) of this gene implicated in familial nephrotic syndrome. Orthologous to human LAMA5 (laminin subunit alpha 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 175.0), Lung (RPKM 146.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q43

Exon count:: 79

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (187647904..187695974, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (167270296..167318370, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (175553042..175601112, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

laminin 5 and collagen IV might be implicated in pseudoislets formation whereas fibronectin might be involved in cell adhesion.
Title: Extracellular matrix proteins involved in pseudoislets formation.
Alterations in airway basement membrane proteins such as laminin alpha5 can induce connexin reorganizations and result in altered cellular communication mechanisms that could contribute to airway tissue function.
Title: Laminin-332 alters connexin profile, dye coupling and intercellular Ca2+ waves in ciliated tracheal epithelial cells.
Data suggest that the early arrest of tumor cells in the pulmonary vasculature through interaction of alpha3beta1 integrin with laminin-5 in exposed basement membrane provides a basis for cell arrest during pulmonary metastasis.
Title: Tumor cell alpha3beta1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis.
laminin 6 and 5 have distinct biological activities, but they may cooperatively support cell adhesion.
Title: Laminin-6 is activated by proteolytic processing and regulates cellular adhesion and migration differently from laminin-5.

Submit: New GeneRIF Correction

General gene information

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Markers

RH128438 (e-PCR)
- UniSTS:211746

RH144643 (e-PCR)
- UniSTS:233888

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell adhesion mediator activity	ISO Inferred from Sequence Orthology more info
enables extracellular matrix structural constituent	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within branching involved in salivary gland morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within morphogenesis of a polarized epithelium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within morphogenesis of embryonic epithelium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle organ development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural crest cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
involved_in postsynapse organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within trunk neural crest cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix of synaptic cleft	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of laminin-10 complex	ISO Inferred from Sequence Orthology more info
part_of laminin-5 complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
is_active_in synaptic cleft	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: laminin subunit alpha-5

Names: laminin, alpha 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191609.1 → NP_001178538.1 laminin subunit alpha-5 precursor

See identical proteins and their annotated locations for NP_001178538.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6A4V6, A6KMB1, F1MAN8

Related

ENSRNOP00000074084.1, ENSRNOT00000081226.3

Conserved Domains (10) summary

smart00180
Location:499 → 546

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:1689 → 1818

LamB; Laminin B domain

smart00282
Location:3151 → 3269

LamG; Laminin G domain

cd00055
Location:681 → 723

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3514 → 3663

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:1581 → 1629

Laminin_EGF; Laminin EGF domain

pfam00055
Location:58 → 302

Laminin_N; Laminin N-terminal (Domain VI)

pfam06008
Location:2189 → 2448

Laminin_I; Laminin Domain I

pfam06009
Location:2639 → 2760

Laminin_II; Laminin Domain II

pfam12795
Location:2397 → 2617

MscS_porin; Mechanosensitive ion channel porin domain