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    Kndc1 kinase non-catalytic C-lobe domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361672, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kndc1provided by RGD
    Official Full Name
    kinase non-catalytic C-lobe domain containing 1provided by RGD
    Primary source
    RGD:1565261
    See related
    EnsemblRapid:ENSRNOG00000027240 AllianceGenome:RGD:1565261
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565261
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of dendrite morphogenesis. Predicted to act upstream of or within cerebellar granule cell differentiation; positive regulation of protein phosphorylation; and regulation of dendrite development. Predicted to be part of guanyl-nucleotide exchange factor complex. Predicted to be active in dendrite and neuronal cell body. Orthologous to human KNDC1 (kinase non-catalytic C-lobe domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 133.7), Lung (RPKM 15.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kndc1 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (204119597..204167967)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (194689962..194738353)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (212229751..212279254)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484917 Neighboring gene adhesion G protein-coupled receptor A1 Neighboring gene uncharacterized LOC134485199 Neighboring gene uncharacterized LOC102553731 Neighboring gene undifferentiated embryonic cell transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Very-KIND, a KIND domain containing RasGEF, controls dendrite growth by linking Ras small GTPases and MAP2. Huang J, et al. J Cell Biol, 2007 Nov 5. PMID 17984326, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cerebellar granule cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of guanyl-nucleotide exchange factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of guanyl-nucleotide exchange factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinase non-catalytic C-lobe domain-containing protein 1
    Names
    kinase non-catalytic C-lobe domain (KIND) containing 1
    protein very KIND

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      204119597..204167967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281019.1 → XP_063137089.1  kinase non-catalytic C-lobe domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GKS6

    2. XM_063281018.1 → XP_063137088.1  kinase non-catalytic C-lobe domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKS6

    3. XM_063281017.1 → XP_063137087.1  kinase non-catalytic C-lobe domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GKS6, D4A8Q2
      Related
      ENSRNOP00000030254.7, ENSRNOT00000034426.8
    Nucleotide Protein Strain
    Heading Accession and Version

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