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    Nek6 NIMA-related kinase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360161, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nek6provided by RGD
    Official Full Name
    NIMA-related kinase 6provided by RGD
    Primary source
    RGD:727779
    See related
    EnsemblRapid:ENSRNOG00000010897 AllianceGenome:RGD:727779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; protein phosphorylation; and regulation of mitotic metaphase/anaphase transition. Predicted to be located in centriolar satellite; cytosol; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to human NEK6 (NIMA related kinase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 69.4), Liver (RPKM 68.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nek6 in Genome Data Viewer
    Location:
    3q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (42693994..42766026)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (22284269..22356302)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (22811927..22888598)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene LIM homeobox 2 Neighboring gene double PHD fingers 3 like 1 Neighboring gene uncharacterized LOC120101538 Neighboring gene proteasome 20S subunit beta 7 Neighboring gene ALG11, alpha-1,2-mannosyltransferase, pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 42
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables ATP binding  
    enables ATP binding  
    enables DNA-binding transcription factor binding  
    enables DNA-binding transcription factor binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables kinesin binding  
    enables kinesin binding  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    enables transcription corepressor binding  
    enables transcription corepressor binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 42
    Process Evidence Code Pubs
    involved_in apoptotic process  
    involved_in cell division  
    involved_in chromatin remodeling  
    involved_in chromosome segregation  
    involved_in chromosome segregation  
    involved_in chromosome segregation  
    involved_in peptidyl-serine phosphorylation  
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in protein autophosphorylation  
    involved_in protein autophosphorylation  
    involved_in protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in regulation of mitotic metaphase/anaphase transition  
    involved_in regulation of mitotic metaphase/anaphase transition  
    involved_in regulation of mitotic metaphase/anaphase transition  
    Component Evidence Code Pubs
    located_in centriolar satellite  
    located_in centriolar satellite  
    located_in centrosome  
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in nuclear speck  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    part_of protein-containing complex  
    part_of protein-containing complex  
    located_in spindle pole  

    General protein information

    Preferred Names
    serine/threonine-protein kinase Nek6
    Names
    NIMA (never in mitosis gene a)-related expressed kinase 6
    never in mitosis A-related kinase 6
    nimA-related protein kinase 6
    NP_001264161.1
    NP_891998.1
    XP_006234162.1
    XP_017447355.1
    XP_038961262.1
    XP_038961263.1
    XP_038961264.1
    XP_038961265.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277232.1NP_001264161.1  serine/threonine-protein kinase Nek6

      See identical proteins and their annotated locations for NP_001264161.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC160820, JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P59895
      UniProtKB/TrEMBL
      A0A8L2R1R0, B1H218
      Conserved Domains (1) summary
      cd08224
      Location:44305
      STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7
    2. NM_182953.2NP_891998.1  serine/threonine-protein kinase Nek6

      See identical proteins and their annotated locations for NP_891998.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC160820, JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P59895
      UniProtKB/TrEMBL
      A0A8L2R1R0, B1H218
      Related
      ENSRNOP00000083098.1, ENSRNOT00000116855.2
      Conserved Domains (1) summary
      cd08224
      Location:44305
      STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      42693994..42766026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234100.3XP_006234162.1  serine/threonine-protein kinase Nek6 isoform X1

      See identical proteins and their annotated locations for XP_006234162.1

      UniProtKB/Swiss-Prot
      P59895
      UniProtKB/TrEMBL
      A0A8L2R1R0, B1H218
      Conserved Domains (1) summary
      cd08224
      Location:44305
      STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7
    2. XM_039105336.2XP_038961264.1  serine/threonine-protein kinase Nek6 isoform X1

      UniProtKB/Swiss-Prot
      P59895
      UniProtKB/TrEMBL
      A0A8L2R1R0, B1H218
      Conserved Domains (1) summary
      cd08224
      Location:44305
      STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7
    3. XM_039105335.2XP_038961263.1  serine/threonine-protein kinase Nek6 isoform X1

      UniProtKB/Swiss-Prot
      P59895
      UniProtKB/TrEMBL
      A0A8L2R1R0, B1H218
      Conserved Domains (1) summary
      cd08224
      Location:44305
      STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7
    4. XM_017591866.3XP_017447355.1  serine/threonine-protein kinase Nek6 isoform X1

      UniProtKB/Swiss-Prot
      P59895
      UniProtKB/TrEMBL
      A0A8L2R1R0, B1H218
      Conserved Domains (1) summary
      cd08224
      Location:44305
      STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7
    5. XM_039105337.2XP_038961265.1  serine/threonine-protein kinase Nek6 isoform X1

      UniProtKB/Swiss-Prot
      P59895
      UniProtKB/TrEMBL
      A0A8L2R1R0, B1H218
      Related
      ENSRNOP00000069207.2, ENSRNOT00000086147.3
      Conserved Domains (1) summary
      cd08224
      Location:44305
      STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7
    6. XM_039105334.2XP_038961262.1  serine/threonine-protein kinase Nek6 isoform X1

      UniProtKB/Swiss-Prot
      P59895
      UniProtKB/TrEMBL
      A0A8L2R1R0, B1H218
      Conserved Domains (1) summary
      cd08224
      Location:44305
      STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7
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