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    Fance FA complementation group E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309643, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fanceprovided by RGD
    Official Full Name
    FA complementation group Eprovided by RGD
    Primary source
    RGD:1561045
    See related
    EnsemblRapid:ENSRNOG00000000504 AllianceGenome:RGD:1561045
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561045
    Summary
    Predicted to be involved in interstrand cross-link repair. Predicted to be located in centrosome; chromatin; and nucleoplasm. Predicted to be part of Fanconi anaemia nuclear complex. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group E. Orthologous to human FANCE (FA complementation group E). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 60.2), Kidney (RPKM 59.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fance in Genome Data Viewer
    Location:
    20p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (6371153..6388366)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (6369416..6386631)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (7888927..7906142)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene DEF6 guanine nucleotide exchange factor Neighboring gene peroxisome proliferator-activated receptor delta Neighboring gene uncharacterized LOC120098961 Neighboring gene transfer RNA proline (anticodon AGG) 65 Neighboring gene ribosomal protein L10A Neighboring gene TEA domain transcription factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Primary Ovarian Insufficiency Induced by Fanconi Anemia E Mutation in a Mouse Model. Fu C, et al. PLoS One, 2016. PMID 26939056, Free PMC Article
    2. Isolation of a cDNA representing the Fanconi anemia complementation group E gene. de Winter JP, et al. Am J Hum Genet, 2000 Nov. PMID 11001585, Free PMC Article
    3. Regulation of Rev1 by the Fanconi anemia core complex. Kim H, et al. Nat Struct Mol Biol, 2012 Jan 22. PMID 22266823, Free PMC Article
    4. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Yan Z, et al. Mol Cell, 2010 Mar 26. PMID 20347428, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in interstrand cross-link repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Fanconi anaemia nuclear complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Fanconi anaemia nuclear complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Fanconi anemia group E protein
    Names
    Fanconi anemia, complementation group E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191718.1 → NP_001178647.1  Fanconi anemia group E protein

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      F1M286
      Related
      ENSRNOP00000006191.8, ENSRNOT00000006191.8
      Conserved Domains (1) summary
      cl12008
      Location:290 → 549
      FANCE_c-term; Fanconi anemia complementation group E protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      6371153..6388366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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