Tnfsf12 TNF superfamily member 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnfsf12provided by RGD
Official Full Name: TNF superfamily member 12provided by RGD
Primary source: RGD:1359620
See related: EnsemblRapid:ENSRNOG00000045670 AllianceGenome:RGD:1359620
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TWEAK; Tnlg4a
Summary: Predicted to enable receptor ligand activity. Predicted to be involved in extrinsic apoptotic signaling pathway and positive regulation of extrinsic apoptotic signaling pathway. Predicted to act upstream of or within positive regulation of protein catabolic process. Predicted to be located in extracellular region and perinuclear region of cytoplasm. Predicted to be active in extracellular space. Orthologous to several human genes including TNFSF12 (TNF superfamily member 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 80.0), Heart (RPKM 57.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (54902616..54912628, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (54403870..54413213, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (56290780..56300137, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TWEAK Knockdown Alleviates Post-Cardiac Arrest Brain Injury via the p38 MAPK/NF-kappaB Pathway.
Title: TWEAK Knockdown Alleviates Post-Cardiac Arrest Brain Injury via the p38 MAPK/NF-κB Pathway.
Unraveling the biomechanistic role of Rac1/TWEAK/Fn14/NF-kappaB intricate network in experimentally doxorubicin-induced cardiotoxicity in rats: The role of curcumin.
Title: Unraveling the biomechanistic role of Rac1/TWEAK/Fn14/NF-κB intricate network in experimentally doxorubicin-induced cardiotoxicity in rats: The role of curcumin.
High TWEAK expression is associated with intracerebral hemorrhage.
Title: LncRNA Snhg3 contributes to dysfunction of cerebral microvascular cells in intracerebral hemorrhage rats by activating the TWEAK/Fn14/STAT3 pathway.
Prenatal hypoxia in rats was not associated with differences in Fn-14 protein expression in either male or female offspring. Cardiomyocytes from prenatal hypoxic male, but not female, offspring had decreased proliferation compared with controls. Activation of the TWEAK/Fn-14 pathway leads to increased proliferation but does not appear to contribute to the reduced cardiomyocyte proliferative capacity in males.
Title: The role of the tumor necrosis factor (TNF)-related weak inducer of apoptosis (TWEAK) in offspring exposed to prenatal hypoxia.
the present study provides molecular evidences that the interaction between endurance training and mammary tumorigenesis is mediated by TWEAK signalling
Title: Long-term exercise training prevents mammary tumorigenesis-induced muscle wasting in rats through the regulation of TWEAK signalling.
Endurance training prevents TWEAK but not myostatin-mediated cardiac remodelling in cancer cachexia
Title: Endurance training prevents TWEAK but not myostatin-mediated cardiac remodelling in cancer cachexia.
TWEAK acts as a potent astrocyte mitogen through the induction of a TGF-alpha/EGFR signaling pathway.
Title: Tumor necrosis factor-like weak inducer of apoptosis induces astrocyte proliferation through the activation of transforming-growth factor-α/epidermal growth factor receptor signaling pathway.
TWEAK/Fn14 axis increased cell proliferation and collagen synthesis by activating the NF-small ka, CyrillicB pathway and increasing MMP-9 activity
Title: TWEAK/Fn14 promotes the proliferation and collagen synthesis of rat cardiac fibroblasts via the NF-кB pathway.
Results suggest that the cardiac TWEAK/Fn14 pathway is modified in response to myocardial injury, inflammation and pressure overload.
Title: Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 during cardiac remodelling in rats.
data establish TWEAK as a positive regulator of cardiomyocyte proliferation
Title: TWEAK is a positive regulator of cardiomyocyte proliferation.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor necrosis factor ligand superfamily member 12

Names: TNF-related weak inducer of apoptosis; tumor necrosis factor ligand 4a; tumor necrosis factor superfamily member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001513.2 → NP_001001513.2 tumor necrosis factor ligand superfamily member 12

See identical proteins and their annotated locations for NP_001001513.2

Status: PROVISIONAL

Source sequence(s)

BC079107

UniProtKB/TrEMBL

D3ZUW9, Q6AYC1, Q6J1A8

Related

ENSRNOP00000091485.2, ENSRNOT00000102944.2

Conserved Domains (1) summary

smart00207
Location:131 → 248

TNF; Tumour necrosis factor family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

54902616..54912628 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246745.5 → XP_006246807.1 tumor necrosis factor ligand superfamily member 12 isoform X1

UniProtKB/TrEMBL

A0A0U5J4Y0, Q6J1A8

Conserved Domains (1) summary

smart00207
Location:132 → 249

TNF; Tumour necrosis factor family