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    Spata7 spermatogenesis associated 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192225, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spata7provided by RGD
    Official Full Name
    spermatogenesis associated 7provided by RGD
    Primary source
    RGD:621010
    See related
    EnsemblRapid:ENSRNOG00000003955 AllianceGenome:RGD:621010
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wmp1; RSD-3
    Summary
    Involved in spermatogenesis. Predicted to be located in cytosol; microtubule cytoskeleton; and photoreceptor connecting cilium. Predicted to be active in cytoskeleton and photoreceptor cell cilium. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 3. Orthologous to human SPATA7 (spermatogenesis associated 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 973.1), Kidney (RPKM 85.5) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spata7 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (123609519..123655001)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (117879828..117925284)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (122603248..122648718)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene potassium two pore domain channel subfamily K member 10 Neighboring gene uncharacterized LOC120103597 Neighboring gene U7 small nuclear RNA Neighboring gene protein tyrosine phosphatase, non-receptor type 21 Neighboring gene uncharacterized LOC134479245 Neighboring gene zinc finger CCCH type containing 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel gene, RSD-3/HSD-3.1, encodes a meiotic-related protein expressed in rat and human testis. Zhang X, et al. J Mol Med (Berl), 2003 Jun. PMID 12736779
    2. Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retina. Eblimit A, et al. Hum Mol Genet, 2015 Mar 15. PMID 25398945, Free PMC Article
    3. SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium. Dharmat R, et al. J Cell Biol, 2018 Aug 6. PMID 29899041, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. isolation and characterization of RSD-3 expressed in the testis
      Title: A novel gene, RSD-3/HSD-3.1, encodes a meiotic-related protein expressed in rat and human testis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in photoreceptor cell maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in photoreceptor cell maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in photoreceptor cell maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in photoreceptor cell maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to photoreceptor connecting cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to photoreceptor connecting cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to photoreceptor connecting cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to photoreceptor outer segment IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to photoreceptor outer segment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in photoreceptor connecting cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor connecting cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in photoreceptor distal connecting cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in photoreceptor distal connecting cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in photoreceptor distal connecting cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor distal connecting cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in rod photoreceptor outer segment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in rod photoreceptor outer segment IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in rod photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    spermatogenesis-associated protein 7 homolog
    Names
    fertility-related protein WMP1
    sperm DNA no.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138862.3 → NP_620217.2  spermatogenesis-associated protein 7 homolog

      Status: VALIDATED

      Source sequence(s)
      BC078728, CK470849, CK600391, JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JEE5, F1LP56
      Related
      ENSRNOP00000005297.5, ENSRNOT00000005297.8
      Conserved Domains (1) summary
      pfam15244
      Location:10 → 406
      HSD3; Spermatogenesis-associated protein 7, or HSD3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      123609519..123655001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240413.5 → XP_006240475.1  spermatogenesis-associated protein 7 homolog isoform X2

      UniProtKB/TrEMBL
      A0A8I6GBQ8
      Related
      ENSRNOP00000091805.2, ENSRNOT00000104996.2
      Conserved Domains (1) summary
      pfam15244
      Location:10 → 374
      HSD3; Spermatogenesis-associated protein 7, or HSD3

    2. XM_006240415.5 → XP_006240477.1  spermatogenesis-associated protein 7 homolog isoform X6

      UniProtKB/Swiss-Prot
      Q9R0A3
      UniProtKB/TrEMBL
      A0A8I6GKR6
      Related
      ENSRNOP00000093644.1, ENSRNOT00000098377.2
      Conserved Domains (1) summary
      pfam15244
      Location:4 → 349
      HSD3; Spermatogenesis-associated protein 7, or HSD3

    3. XM_063261533.1 → XP_063117603.1  spermatogenesis-associated protein 7 homolog isoform X4

      UniProtKB/TrEMBL
      A0A8I6GBQ8

    4. XM_063261535.1 → XP_063117605.1  spermatogenesis-associated protein 7 homolog isoform X8

      UniProtKB/Swiss-Prot
      Q9R0A3

    5. XM_006240414.5 → XP_006240476.1  spermatogenesis-associated protein 7 homolog isoform X5

      UniProtKB/Swiss-Prot
      Q9R0A3
      Conserved Domains (1) summary
      pfam15244
      Location:1 → 355
      HSD3; Spermatogenesis-associated protein 7, or HSD3

    6. XM_063261534.1 → XP_063117604.1  spermatogenesis-associated protein 7 homolog isoform X7

      UniProtKB/Swiss-Prot
      Q9R0A3

    7. XM_008764737.3 → XP_008762959.1  spermatogenesis-associated protein 7 homolog isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZZV7
      Related
      ENSRNOP00000085724.1, ENSRNOT00000118680.2
      Conserved Domains (1) summary
      pfam15244
      Location:1 → 300
      HSD3; Spermatogenesis-associated protein 7, or HSD3

    8. XM_039111756.2 → XP_038967684.1  spermatogenesis-associated protein 7 homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZV7, A0A8I6AZX0
      Conserved Domains (1) summary
      pfam15244
      Location:43 → 368
      HSD3; Spermatogenesis-associated protein 7, or HSD3

    9. XM_063261531.1 → XP_063117601.1  spermatogenesis-associated protein 7 homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZV7, A0A8I6AZX0
      Related
      ENSRNOP00000094270.1, ENSRNOT00000108318.2

    10. XM_039111753.2 → XP_038967681.1  spermatogenesis-associated protein 7 homolog isoform X1

      UniProtKB/TrEMBL
      A6JEE5
      Related
      ENSRNOP00000091876.2, ENSRNOT00000097471.2
      Conserved Domains (1) summary
      pfam15244
      Location:9 → 391
      HSD3; Spermatogenesis-associated protein 7, or HSD3

    11. XM_063261532.1 → XP_063117602.1  spermatogenesis-associated protein 7 homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZV7, A0A8I6AZX0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0A3.1 GenPept UniProtKB/Swiss-Prot:Q9R0A3

    Gene LinkOut

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