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Rims2 regulating synaptic membrane exocytosis 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116839, updated on 14-Nov-2024

Summary

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Symbol: Rims2provided by RGD
Full Name: regulating synaptic membrane exocytosis 2provided by RGD
Primary source: RGD:620001
See related: EnsemblRapid:ENSRNOG00000004201 AllianceGenome:RGD:620001
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nim2; Rim2
Summary: Enables protein domain specific binding activity. Predicted to be involved in several processes, including regulation of nervous system process; regulation of vesicle-mediated transport; and signal release. Predicted to act upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway; maintenance of presynaptic active zone structure; and neurotransmitter secretion. Part of protein-containing complex. Is active in photoreceptor ribbon synapse and presynaptic active zone cytoplasmic component. Orthologous to human RIMS2 (regulating synaptic membrane exocytosis 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 133.7), Testes (RPKM 22.9) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Rims2 in Genome Data Viewer

Location:: 7q31

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (72133004..72644059)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (70248104..70759134)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (78091998..78594164)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The crystal structure of RIM2 C2A-domain using data to 1.4 A resolution reveals a beta-sandwich, but exhibits a unique dipolar distribution of electrostatic charges whereby one edge of beta-sandwich is highly positive & the other edge is highly negative.
Title: Crystal structure of the RIM2 C2A-domain at 1.4 A resolution.
These data demonstrate that alpha-RIMs are not essential for synapse formation or synaptic exocytosis, but are required for normal Ca(2+)-triggering of exocytosis.
Title: Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.
Study shows that the Munc13-1 C(2)A domain homodimerizes, and that homodimerization competes with Munc13-1/RIM heterodimerization.
Title: Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU047278 (e-PCR)
- UniSTS:110666

Syt3-rs (e-PCR), detects polymorphism
- UniSTS:144532

D7Got66 (e-PCR)
- UniSTS:115357

D8S1580 (e-PCR)
- UniSTS:34726

D6Got190 (e-PCR)
- UniSTS:115397

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of presynaptic active zone	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of presynaptic active zone	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion-regulated exocytosis of neurotransmitter	ISO Inferred from Sequence Orthology more info
involved_in calcium ion-regulated exocytosis of neurotransmitter	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within calcium-ion regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in calcium-ion regulated exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inhibitory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inhibitory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of calcium-dependent activation of synaptic vesicle fusion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of exocytosis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in spontaneous neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in spontaneous neurotransmitter secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle docking	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle priming	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle priming	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in inhibitory synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in photoreceptor ribbon synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone cytoplasmic component	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic active zone cytoplasmic component	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: regulating synaptic membrane exocytosis protein 2

Names: RIM 2; rab-3-interacting molecule 2; rab3-interacting molecule 2; regulating synaptic membrane exocytosis protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053945.2 → NP_446397.1 regulating synaptic membrane exocytosis protein 2 isoform 1

See identical proteins and their annotated locations for NP_446397.1

Status: PROVISIONAL

Source sequence(s)

AF199322

UniProtKB/Swiss-Prot

Q8CIX2, Q9JHJ6, Q9JIR2, Q9JIR5, Q9JIR6, Q9JIR7, Q9JIR8, Q9JIR9, Q9JIS0, Q9JIS1

UniProtKB/TrEMBL

A6HR72, F1LNC5

Related

ENSRNOP00000043010.5, ENSRNOT00000050753.6

Conserved Domains (5) summary

cd04028
Location:1386 → 1531

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:746 → 869

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

PHA02666
Location:970 → 1067

PHA02666; hypothetical protein; Provisional

cd00992
Location:593 → 674

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:30 → 154

PHD_SF; PHD finger superfamily
NM_145881.2 → NP_665888.1 regulating synaptic membrane exocytosis protein 2 isoform 2

See identical proteins and their annotated locations for NP_665888.1

Status: PROVISIONAL

Source sequence(s)

AF199335

UniProtKB/TrEMBL

A6HR81

Conserved Domains (1) summary

cd04028
Location:116 → 261

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

72133004..72644059

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078274.2 → XP_038934202.1 regulating synaptic membrane exocytosis protein 2 isoform X4

UniProtKB/TrEMBL

A0A096P6M3

Conserved Domains (5) summary

TIGR00934
Location:929 → 1223

2a38euk; potassium uptake protein, Trk family

cd04028
Location:1535 → 1680

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:854 → 977

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:701 → 782

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:192 → 242

PHD_SF; PHD finger superfamily
XM_039078264.2 → XP_038934192.1 regulating synaptic membrane exocytosis protein 2 isoform X1

UniProtKB/TrEMBL

A0A096P6M3

Conserved Domains (4) summary

cd04028
Location:1557 → 1702

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:881 → 1004

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:728 → 809

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:192 → 242

PHD_SF; PHD finger superfamily
XM_063262877.1 → XP_063118947.1 regulating synaptic membrane exocytosis protein 2 isoform X7
XM_039078271.2 → XP_038934199.1 regulating synaptic membrane exocytosis protein 2 isoform X2

UniProtKB/TrEMBL

A0A096P6M3

Conserved Domains (4) summary

cd04028
Location:1546 → 1691

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:881 → 1004

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:728 → 809

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:192 → 242

PHD_SF; PHD finger superfamily
XM_039078273.2 → XP_038934201.1 regulating synaptic membrane exocytosis protein 2 isoform X3

UniProtKB/TrEMBL

A0A096P6M3

Conserved Domains (4) summary

cd04028
Location:1535 → 1680

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:881 → 1004

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:728 → 809

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:192 → 242

PHD_SF; PHD finger superfamily
XM_039078279.2 → XP_038934207.1 regulating synaptic membrane exocytosis protein 2 isoform X10

UniProtKB/TrEMBL

A0A8I6A6L6

Conserved Domains (5) summary

cd04028
Location:1475 → 1620

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:881 → 1004

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

PHA03307
Location:1012 → 1188

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:728 → 809

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:192 → 242

PHD_SF; PHD finger superfamily
XM_063262880.1 → XP_063118950.1 regulating synaptic membrane exocytosis protein 2 isoform X13
XM_039078275.2 → XP_038934203.1 regulating synaptic membrane exocytosis protein 2 isoform X5

UniProtKB/TrEMBL

A0A096P6M3

Conserved Domains (4) summary

cd04028
Location:1534 → 1679

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:881 → 1004

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:728 → 809

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:192 → 242

PHD_SF; PHD finger superfamily
XM_039078280.2 → XP_038934208.1 regulating synaptic membrane exocytosis protein 2 isoform X11

UniProtKB/TrEMBL

A0A8I6A6L6

Conserved Domains (4) summary

cd04028
Location:1474 → 1619

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:881 → 1004

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:728 → 809

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:192 → 242

PHD_SF; PHD finger superfamily
XM_063262878.1 → XP_063118948.1 regulating synaptic membrane exocytosis protein 2 isoform X8
XM_063262879.1 → XP_063118949.1 regulating synaptic membrane exocytosis protein 2 isoform X9
XM_063262882.1 → XP_063118952.1 regulating synaptic membrane exocytosis protein 2 isoform X15
XM_063262894.1 → XP_063118964.1 regulating synaptic membrane exocytosis protein 2 isoform X46

Related

ENSRNOP00000087824.2, ENSRNOT00000106052.2
XM_039078276.2 → XP_038934204.1 regulating synaptic membrane exocytosis protein 2 isoform X6

UniProtKB/TrEMBL

F1LNC5

Conserved Domains (5) summary

TIGR00934
Location:912 → 1206

2a38euk; potassium uptake protein, Trk family

cd04028
Location:1518 → 1663

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:837 → 960

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:684 → 765

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:30 → 198

PHD_SF; PHD finger superfamily
XM_039078281.2 → XP_038934209.1 regulating synaptic membrane exocytosis protein 2 isoform X12

UniProtKB/TrEMBL

A0A8I6A6L6

Conserved Domains (4) summary

cd04028
Location:1466 → 1611

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:818 → 944

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:684 → 765

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:30 → 198

PHD_SF; PHD finger superfamily
XM_063262893.1 → XP_063118963.1 regulating synaptic membrane exocytosis protein 2 isoform X45
XM_017594608.3 → XP_017450097.1 regulating synaptic membrane exocytosis protein 2 isoform X27

UniProtKB/TrEMBL

A6HR79
XM_063262886.1 → XP_063118956.1 regulating synaptic membrane exocytosis protein 2 isoform X20
XM_008765447.4 → XP_008763669.1 regulating synaptic membrane exocytosis protein 2 isoform X25

UniProtKB/TrEMBL

A0A8I5ZP02, A0A8I6A6L6

Related

ENSRNOP00000079853.1, ENSRNOT00000116297.2

Conserved Domains (4) summary

cd04028
Location:1361 → 1506

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:814 → 940

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:680 → 761

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:30 → 194

PHD_SF; PHD finger superfamily
XM_063262883.1 → XP_063118953.1 regulating synaptic membrane exocytosis protein 2 isoform X16
XM_063262895.1 → XP_063118965.1 regulating synaptic membrane exocytosis protein 2 isoform X47
XM_017594609.3 → XP_017450098.1 regulating synaptic membrane exocytosis protein 2 isoform X31

UniProtKB/TrEMBL

A6HR78
XM_063262884.1 → XP_063118954.1 regulating synaptic membrane exocytosis protein 2 isoform X17
XM_039078289.2 → XP_038934217.1 regulating synaptic membrane exocytosis protein 2 isoform X32

UniProtKB/TrEMBL

A6HR78

Related

ENSRNOP00000006393.3, ENSRNOT00000006393.6

Conserved Domains (4) summary

cd04028
Location:1163 → 1308

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:727 → 853

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:593 → 674

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:30 → 154

PHD_SF; PHD finger superfamily
XM_039078290.2 → XP_038934218.1 regulating synaptic membrane exocytosis protein 2 isoform X34

UniProtKB/TrEMBL

A6HR77

Conserved Domains (4) summary

cd04028
Location:1103 → 1248

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:727 → 853

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:593 → 674

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:30 → 154

PHD_SF; PHD finger superfamily
XM_063262885.1 → XP_063118955.1 regulating synaptic membrane exocytosis protein 2 isoform X19
XM_006241593.5 → XP_006241655.1 regulating synaptic membrane exocytosis protein 2 isoform X24

UniProtKB/TrEMBL

A6HR74

Conserved Domains (5) summary

cd04028
Location:1370 → 1515

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:727 → 853

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

PHA02666
Location:954 → 1051

PHA02666; hypothetical protein; Provisional

cd00992
Location:593 → 674

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:30 → 154

PHD_SF; PHD finger superfamily
XM_006241594.5 → XP_006241656.1 regulating synaptic membrane exocytosis protein 2 isoform X26

UniProtKB/TrEMBL

A6HR75

Conserved Domains (5) summary

cd04028
Location:1356 → 1501

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:727 → 853

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

PHA02666
Location:954 → 1051

PHA02666; hypothetical protein; Provisional

cd00992
Location:593 → 674

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:30 → 154

PHD_SF; PHD finger superfamily
XM_063262888.1 → XP_063118958.1 regulating synaptic membrane exocytosis protein 2 isoform X23

Related

ENSRNOP00000112184.1, ENSRNOT00000124088.1
XM_039078284.2 → XP_038934212.1 regulating synaptic membrane exocytosis protein 2 isoform X28

UniProtKB/TrEMBL

A6HR79

Conserved Domains (4) summary

cd04028
Location:1232 → 1377

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:774 → 900

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:640 → 721

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:30 → 154

PHD_SF; PHD finger superfamily
XM_063262887.1 → XP_063118957.1 regulating synaptic membrane exocytosis protein 2 isoform X21
XM_063262881.1 → XP_063118951.1 regulating synaptic membrane exocytosis protein 2 isoform X14
XM_006241591.5 → XP_006241653.1 regulating synaptic membrane exocytosis protein 2 isoform X18

UniProtKB/TrEMBL

A0A096P6M8, A6HR75

Related

ENSRNOP00000047914.5, ENSRNOT00000039984.7

Conserved Domains (5) summary

cd04028
Location:1403 → 1548

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:774 → 900

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

PHA02666
Location:1001 → 1098

PHA02666; hypothetical protein; Provisional

cd00992
Location:640 → 721

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:30 → 154

PHD_SF; PHD finger superfamily
XM_006241592.5 → XP_006241654.1 regulating synaptic membrane exocytosis protein 2 isoform X22

UniProtKB/TrEMBL

A0A8I5ZVS6, A6HR75

Conserved Domains (4) summary

cd04028
Location:1381 → 1526

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:774 → 900

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:640 → 721

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:30 → 154

PHD_SF; PHD finger superfamily
XM_039078291.2 → XP_038934219.1 regulating synaptic membrane exocytosis protein 2 isoform X35

UniProtKB/TrEMBL

A6HR80

Conserved Domains (3) summary

cd04028
Location:1040 → 1185

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:582 → 708

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:448 → 529

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_017594611.3 → XP_017450100.1 regulating synaptic membrane exocytosis protein 2 isoform X36

UniProtKB/TrEMBL

A6HR80
XM_039078287.2 → XP_038934215.1 regulating synaptic membrane exocytosis protein 2 isoform X30

UniProtKB/TrEMBL

A6HR80

Conserved Domains (3) summary

cd04028
Location:1183 → 1328

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:535 → 661

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:401 → 482

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_039078294.2 → XP_038934222.1 regulating synaptic membrane exocytosis protein 2 isoform X43

UniProtKB/TrEMBL

A6HR77

Conserved Domains (3) summary

cd04028
Location:911 → 1056

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:535 → 661

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:401 → 482

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_017594612.3 → XP_017450101.1 regulating synaptic membrane exocytosis protein 2 isoform X37

UniProtKB/TrEMBL

A6HR80
XM_039078292.2 → XP_038934220.1 regulating synaptic membrane exocytosis protein 2 isoform X39

UniProtKB/TrEMBL

A6HR80

Conserved Domains (3) summary

cd04028
Location:987 → 1132

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:554 → 677

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:401 → 482

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006241598.5 → XP_006241660.1 regulating synaptic membrane exocytosis protein 2 isoform X29

UniProtKB/TrEMBL

A6HR80

Conserved Domains (4) summary

cd04028
Location:1194 → 1339

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:554 → 677

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

PHA02666
Location:778 → 875

PHA02666; hypothetical protein; Provisional

cd00992
Location:401 → 482

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_039078293.2 → XP_038934221.1 regulating synaptic membrane exocytosis protein 2 isoform X41

UniProtKB/TrEMBL

A6HR80

Conserved Domains (3) summary

cd04028
Location:971 → 1116

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:535 → 661

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:401 → 482

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_063262891.1 → XP_063118961.1 regulating synaptic membrane exocytosis protein 2 isoform X40
XM_063262896.1 → XP_063118966.1 regulating synaptic membrane exocytosis protein 2 isoform X48
XM_063262890.1 → XP_063118960.1 regulating synaptic membrane exocytosis protein 2 isoform X38
XM_063262892.1 → XP_063118962.1 regulating synaptic membrane exocytosis protein 2 isoform X42
XM_063262889.1 → XP_063118959.1 regulating synaptic membrane exocytosis protein 2 isoform X33
XM_039078295.2 → XP_038934223.1 regulating synaptic membrane exocytosis protein 2 isoform X44

Conserved Domains (1) summary

cd04028
Location:198 → 343

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins