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    Shbg sex hormone binding globulin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24775, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Shbgprovided by RGD
    Official Full Name
    sex hormone binding globulinprovided by RGD
    Primary source
    RGD:3671
    See related
    EnsemblRapid:ENSRNOG00000011357 AllianceGenome:RGD:3671
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Abpa
    Summary
    Predicted to enable steroid binding activity. Involved in primary spermatocyte growth. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in endometrial cancer and type 2 diabetes mellitus. Orthologous to human SHBG (sex hormone binding globulin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 84.4), Kidney (RPKM 10.3) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Shbg in Genome Data Viewer
    Location:
    10q24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54831716..54849162, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54332939..54350409, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56219861..56237354, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATPase Na+/K+ transporting subunit beta 2 Neighboring gene uncharacterized LOC134480815 Neighboring gene spermidine/spermine N1-acetyltransferase family member 2 Neighboring gene FMR1 autosomal homolog 2 Neighboring gene SRY-box transcription factor 15 Neighboring gene mannose-P-dolichol utilization defect 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sex hormone binding globulin in the rat olfactory system. Ploss V, et al. J Chem Neuroanat, 2014 May. PMID 24681170
    2. The androgen-binding protein gene is expressed in male and female rat brain. Wang YM, et al. Endocrinology, 1990 Dec. PMID 1701136
    3. Analysis of the steroid binding domain of rat androgen-binding protein. Danzo BJ, et al. Endocrinology, 1991 Aug. PMID 1855466
    4. Rat androgen-binding protein: evidence for identical subunits and amino acid sequence homology with human sex hormone-binding globulin. Joseph DR, et al. Proc Natl Acad Sci U S A, 1987 Jan. PMID 2432609, Free PMC Article
    5. The gene structure of rat androgen-binding protein: identification of potential regulatory deoxyribonucleic acid elements of a follicle-stimulating hormone-regulated protein. Joseph DR, et al. Mol Endocrinol, 1988 Jan. PMID 2840566

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aging-related increases in serum sex hormone-binding globulin levels in men might be related to increased synthesis.
      Title: Aging-related increases in serum sex hormone-binding globulin levels in men might be related to increased synthesis.
    2. SHBG may be of functional importance for rapid effects of olfactory steroids on limbic functions including the control of reproductive behaviours through pheromones
      Title: Sex hormone binding globulin in the rat olfactory system.
    3. Fluorine had no effect on the expression of androgen binding protein and inhibin B mRNA in testis sertoli cells of Sprague Dawley rats.
      Title: [Influence of fluorine on expression of androgen-binding protein and inhibin B mRNA in rat testis sertoli cells].
    4. Upstream stimulatory factors (USF1 and USF2) induce Nr5a1 and Shbg gene expression during the onset of rat Sertoli cell differentiation.
      Title: Upstream stimulatory factor induces Nr5a1 and Shbg gene expression during the onset of rat Sertoli cell differentiation.
    5. Data show that the use of alternative SHBG first exons 1A and 1B differentially inhibits translation from the ATG situated in exon 2, which codes for methionine 30 of transcripts that begin with the exon 1 sequence.
      Title: Human SHBG mRNA translation is modulated by alternative 5'-non-coding exons 1A and 1B.
    6. Results suggest that Sertoli cell-derived androgen-binding protein acts on spermatids by modifying the transition protein-1 mRNA level.
      Title: Effects of androgen-binding protein (ABP) on spermatid Tnp1 gene expression in vitro.
    7. ABP was found in neurons of the magnocellular hypothalamic nuclei, the preoptic region and the lateral hypothalamus. ABP varicosities occurred throughout the hypothalamus, the median eminence and the posterior pituitary.
      Title: Distribution of androgen-binding protein in the rat hypothalamo-neurohypophyseal system, co-localization with oxytocin.
    8. Estrogen receptor beta was strongly immunolabeled in pachytene spermatocytes of rat androgen-binding protein transgenic mice and localized in tubular stages in which TUNEL labeling was maximal.
      Title: Estrogen receptor beta expression and apoptosis of spermatocytes of mice overexpressing a rat androgen-binding protein transgene.
    9. Intrahypothalamic expression of ABP may be among the mechanisms necessary for rapid actions of steroids on hypothalamic neuroendocrine systems.
      Title: Co-expression of vasopressin and androgen-binding protein in the rat hypothalamus.
    10. There is a significantly higher level of the Shbg transcript in hypodactylous rats compared to SHR controls.
      Title: Molecular analysis of the sex hormone-binding globulin gene in the rat hypodactylous mutation (Hd).
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables steroid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in primary spermatocyte growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sex hormone-binding globulin
    Names
    ABP
    SBP
    Sex hormone binding globulin or androgen-binding protein (other gene product from ABP gene)
    androgen binding protein
    sex steroid-binding protein
    testis-specific androgen-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429980.1 → NP_001416909.1  sex hormone-binding globulin isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    2. NM_001429981.1 → NP_001416910.1  sex hormone-binding globulin isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    3. NM_001429983.1 → NP_001416912.1  sex hormone-binding globulin isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    4. NM_012650.3 → NP_036782.1  sex hormone-binding globulin isoform a precursor

      See identical proteins and their annotated locations for NP_036782.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P08689, Q4QR94
      UniProtKB/TrEMBL
      A6HFS0
      Conserved Domains (1) summary
      pfam00054
      Location:76 → 206
      Laminin_G_1; Laminin G domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      54831716..54849162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246592.5 → XP_006246654.1  sex hormone-binding globulin isoform X3

      UniProtKB/TrEMBL
      A0A8I6AMK2
      Conserved Domains (1) summary
      pfam00054
      Location:85 → 215
      Laminin_G_1; Laminin G domain

    2. XM_008767771.3 → XP_008765993.1  sex hormone-binding globulin isoform X2

      See identical proteins and their annotated locations for XP_008765993.1

      UniProtKB/TrEMBL
      A0A8I5Y0E6
      Conserved Domains (2) summary
      pfam00054
      Location:87 → 217
      Laminin_G_1; Laminin G domain
      cl22861
      Location:236 → 301
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    3. XM_039085222.1 → XP_038941150.1  sex hormone-binding globulin isoform X4

      Conserved Domains (1) summary
      pfam00054
      Location:1 → 109
      Laminin_G_1; Laminin G domain

    4. XM_017597013.2 → XP_017452502.1  sex hormone-binding globulin isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y0E6
      Conserved Domains (2) summary
      pfam00054
      Location:87 → 217
      Laminin_G_1; Laminin G domain
      cl22861
      Location:236 → 301
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    5. XM_039085221.2 → XP_038941149.1  sex hormone-binding globulin isoform X4

      Conserved Domains (1) summary
      pfam00054
      Location:1 → 109
      Laminin_G_1; Laminin G domain

    6. XM_063268425.1 → XP_063124495.1  sex hormone-binding globulin isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y0E6
      Related
      ENSRNOP00000076817.1, ENSRNOT00000102053.2

    7. XM_006246586.5 → XP_006246648.1  sex hormone-binding globulin isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHJ0
      Related
      ENSRNOP00000015248.3, ENSRNOT00000015248.6
      Conserved Domains (1) summary
      pfam00054
      Location:118 → 248
      Laminin_G_1; Laminin G domain

    8. XM_039085224.2 → XP_038941152.1  sex hormone-binding globulin isoform X5

      Conserved Domains (1) summary
      cl22861
      Location:1 → 70
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08689.1 GenPept UniProtKB/Swiss-Prot:P08689

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