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    ZNF704 zinc finger protein 704 [ Homo sapiens (human) ]

    Gene ID: 619279, updated on 9-Dec-2024

    Summary

    Official Symbol
    ZNF704provided by HGNC
    Official Full Name
    zinc finger protein 704provided by HGNC
    Primary source
    HGNC:HGNC:32291
    See related
    Ensembl:ENSG00000164684 AllianceGenome:HGNC:32291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Gig1
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in endometrium (RPKM 8.6), ovary (RPKM 8.1) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZNF704 in Genome Data Viewer
    Location:
    8q21.13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (80628451..80884419, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (81060029..81315991, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (81540686..81787016, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene SLC25A51 pseudogene 3 Neighboring gene RNA, 7SL, cytoplasmic 107, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:81552571-81553770 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:81610513-81611014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:81611015-81611514 Neighboring gene RNA, U11 small nuclear 6, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 308, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:81734976-81736175 Neighboring gene high mobility group box 1 pseudogene 41 Neighboring gene MPRA-validated peak7088 silencer Neighboring gene uncharacterized LOC107986894 Neighboring gene HNF4 motif-containing MPRA enhancer 108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27570 Neighboring gene uncharacterized LOC124901967 Neighboring gene phosphoprotein membrane anchor with glycosphingolipid microdomains 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ16218, MGC10858

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033723.3NP_001028895.1  zinc finger protein 704 isoform 1

      See identical proteins and their annotated locations for NP_001028895.1

      Status: VALIDATED

      Source sequence(s)
      AC022598, AK131274, BC004287, BM683148, BX112159
      Consensus CDS
      CCDS34913.1
      UniProtKB/Swiss-Prot
      B2RNE6, B9EGW6, Q6ZNC4
      Related
      ENSP00000331462.3, ENST00000327835.7
      Conserved Domains (1) summary
      cl25496
      Location:248374
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    2. NM_001367783.1NP_001354712.1  zinc finger protein 704 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022598, AC024367
      Consensus CDS
      CCDS94322.1
      UniProtKB/TrEMBL
      E5RGL7
      Related
      ENSP00000427715.2, ENST00000519936.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      80628451..80884419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013725.2XP_016869214.1  zinc finger protein 704 isoform X1

    RNA

    1. XR_928797.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      81060029..81315991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360961.1XP_054216936.1  zinc finger protein 704 isoform X1

    RNA

    1. XR_008487869.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032651.1: Suppressed sequence

      Description
      NM_032651.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.