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    CRHR2 corticotropin releasing hormone receptor 2 [ Homo sapiens (human) ]

    Gene ID: 1395, updated on 27-Nov-2024

    Summary

    Official Symbol
    CRHR2provided by HGNC
    Official Full Name
    corticotropin releasing hormone receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:2358
    See related
    Ensembl:ENSG00000106113 MIM:602034; AllianceGenome:HGNC:2358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRF2; CRFR2; CRF-RB; HM-CRF
    Summary
    The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CRHR2 in Genome Data Viewer
    Location:
    7p14.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (30651942..30700103, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (30789546..30837766, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (30691558..30739719, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:30588305-30588806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25815 Neighboring gene GARS1 divergent transcript Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:30633949-30634562 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:30634563-30635176 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:30635177-30635790 Neighboring gene glycyl-tRNA synthetase 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:30681423-30682118 Neighboring gene uncharacterized LOC124901609 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:30692507-30693496 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:30694345-30695544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30701754-30702296 Neighboring gene MPRA-validated peak6463 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18070 Neighboring gene uncharacterized LOC124901608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30727952-30728462 Neighboring gene uncharacterized LOC105375220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30747055-30747555 Neighboring gene uncharacterized LOC105375219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30766987-30767488 Neighboring gene INMT-MINDY4 readthrough (NMD candidate) Neighboring gene indolethylamine N-methyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables corticotrophin-releasing factor receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables corticotropin-releasing hormone receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to corticotropin-releasing hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hormone-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-term synaptic potentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in axon terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    corticotropin-releasing factor receptor 2
    Names
    CRH-R2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029169.1 RefSeqGene

      Range
      22648..53162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202475.1NP_001189404.1  corticotropin-releasing factor receptor 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001189404.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains additional in-frame coding exons at the 5' end compared to variant 1, resulting in an isoform (2, also known as beta isoform) with a longer and distinct N-terminus compared to isoform 1. This receptor subtype was shown to mediate urocortin-induced MAPK activation in human myometrium (PMID:11117536).
      Source sequence(s)
      AC004976, AF011406, CN367944, DB308619, U34587
      Consensus CDS
      CCDS56478.1
      UniProtKB/Swiss-Prot
      Q13324
      Related
      ENSP00000340943.4, ENST00000348438.8
      Conserved Domains (2) summary
      smart00008
      Location:63134
      HormR; Domain present in hormone receptors
      pfam00002
      Location:140382
      7tm_2; 7 transmembrane receptor (Secretin family)
    2. NM_001202481.1NP_001189410.1  corticotropin-releasing factor receptor 2 isoform 3

      See identical proteins and their annotated locations for NP_001189410.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains additional exons at the 5' end compared to variant 1, resulting in a shorter isoform (3, also known as gamma isoform) with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC004976, AF011406, AF019381, CN367944, DB308619, U34587, Y10153
      Consensus CDS
      CCDS56477.1
      UniProtKB/Swiss-Prot
      Q13324
      Related
      ENSP00000344304.4, ENST00000341843.8
      Conserved Domains (2) summary
      smart00008
      Location:2293
      HormR; Domain present in hormone receptors
      pfam00002
      Location:99341
      7tm_2; 7 transmembrane receptor (Secretin family)
    3. NM_001202482.2NP_001189411.1  corticotropin-releasing factor receptor 2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame acceptor splice site at one of the coding exons compared to variant 1, resulting in an isoform (4, also known as isoform desQ) 1 aa shorter than isoform 1.
      Source sequence(s)
      AC004976, AF011406, CN367944, DA808296, DB308619, EU012443, U34587
      UniProtKB/Swiss-Prot
      Q13324
      Conserved Domains (2) summary
      smart00008
      Location:36107
      HormR; Domain present in hormone receptors
      pfam00002
      Location:112354
      7tm_2; 7 transmembrane receptor (Secretin family)
    4. NM_001202483.2NP_001189412.1  corticotropin-releasing factor receptor 2 isoform 5

      See identical proteins and their annotated locations for NP_001189412.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an additional exon at the penultimate position compared to variant 1, resulting in a frame-shift and a shorter isoform (5, also known as isoform D) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC004976, AK313661, CN367944, DA808296, DB308619, EU012439, U34587
      Consensus CDS
      CCDS75576.1
      UniProtKB/Swiss-Prot
      Q13324
      Related
      ENSP00000426498.3, ENST00000506074.6
      Conserved Domains (2) summary
      smart00008
      Location:36107
      HormR; Domain present in hormone receptors
      pfam00002
      Location:113355
      7tm_2; 7 transmembrane receptor (Secretin family)
    5. NM_001883.5NP_001874.2  corticotropin-releasing factor receptor 2 isoform 1

      See identical proteins and their annotated locations for NP_001874.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1 (also known as alpha isoform).
      Source sequence(s)
      AC004976, AK313661, CN367944, DA808296, DB308619, U34587
      Consensus CDS
      CCDS5429.1
      UniProtKB/Swiss-Prot
      B2R967, B3SXS6, B3SXS7, B3SXS8, B3SXT0, F8WA81, O43461, Q13324, Q4QRJ4, Q99431
      UniProtKB/TrEMBL
      A0A090N7T4
      Related
      ENSP00000418722.1, ENST00000471646.6
      Conserved Domains (2) summary
      smart00008
      Location:36107
      HormR; Domain present in hormone receptors
      cd15446
      Location:113376
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      30651942..30700103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419893.1XP_047275849.1  corticotropin-releasing factor receptor 2 isoform X2

    2. XM_047419892.1XP_047275848.1  corticotropin-releasing factor receptor 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      30789546..30837766 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357267.1XP_054213242.1  corticotropin-releasing factor receptor 2 isoform X2

    2. XM_054357266.1XP_054213241.1  corticotropin-releasing factor receptor 2 isoform X1