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    MRPS30 mitochondrial ribosomal protein S30 [ Homo sapiens (human) ]

    Gene ID: 10884, updated on 9-Dec-2024

    Summary

    Official Symbol
    MRPS30provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein S30provided by HGNC
    Primary source
    HGNC:HGNC:8769
    See related
    Ensembl:ENSG00000112996 MIM:611991; AllianceGenome:HGNC:8769
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAP; mL65; PDCD9; S30mt; MRP-S30
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 11.2), kidney (RPKM 11.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MRPS30 in Genome Data Viewer
    Location:
    5p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (44808947..44815514)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (45062653..45069220)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (44809049..44815616)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 383, pseudogene Neighboring gene MRPS30 divergent transcript Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:44808788-44809444 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:44809445-44810100 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:44875560-44876759 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:44911606-44912309 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:44960236-44960452 Neighboring gene uncharacterized LOC124901180 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:45288792-45289361 Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium channel 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:45385335-45386534 Neighboring gene NANOG hESC enhancer GRCh37_chr5:45398997-45399517 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:45694855-45695356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:45695357-45695856

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    large ribosomal subunit protein mL65
    Names
    28S ribosomal protein S30, mitochondrial
    39S ribosomal protein S30, mitochondrial
    large ribosomal subunit protein mS30
    mitochondrial large ribosomal subunit protein mL65
    mitochondrial large ribosomal subunit protein mS30
    programmed cell death 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016640.4NP_057724.2  large ribosomal subunit protein mL65

      See identical proteins and their annotated locations for NP_057724.2

      Status: REVIEWED

      Source sequence(s)
      AF146192, BC007735, BU676154
      Consensus CDS
      CCDS3951.1
      UniProtKB/Swiss-Prot
      Q96I91, Q96Q19, Q9H0P8, Q9NP92, Q9NSF9, Q9NZ76
      UniProtKB/TrEMBL
      Q53GN7, Q53H77
      Related
      ENSP00000424328.1, ENST00000507110.6
      Conserved Domains (1) summary
      pfam07147
      Location:1426
      PDCD9; Mitochondrial 28S ribosomal protein S30 (PDCD9)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      44808947..44815514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      45062653..45069220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)