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    MIR135A2 microRNA 135a-2 [ Homo sapiens (human) ]

    Gene ID: 406926, updated on 9-Dec-2024

    Summary

    Official Symbol
    MIR135A2provided by HGNC
    Official Full Name
    microRNA 135a-2provided by HGNC
    Primary source
    HGNC:HGNC:31521
    See related
    Ensembl:ENSG00000207586 miRBase:MI0000453; AllianceGenome:HGNC:31521
    Gene type
    ncRNA
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIRN135-2; MIRN135A2; mir-135a-2
    Summary
    microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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    Genomic context

    See MIR135A2 in Genome Data Viewer
    Location:
    12q23.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (97563812..97563911)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (97536995..97537094)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (97957590..97957689)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:97668725-97669520 Neighboring gene long intergenic non-protein coding RNA 2409 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:97857979-97858802 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:97858803-97859626 Neighboring gene NANOG hESC enhancer GRCh37_chr12:97913914-97914415 Neighboring gene rhabdomyosarcoma 2 associated transcript Neighboring gene microRNA 1251 Neighboring gene NFE2L2 motif-containing MPRA enhancer 214 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:98002200-98002744 Neighboring gene NANOG hESC enhancer GRCh37_chr12:98033470-98033981 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:98050058-98050648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4749 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:98117503-98118004 Neighboring gene PAFAH1B2 pseudogene 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:98145599-98146798 Neighboring gene RNA, U6 small nuclear 36, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:98178628-98179251 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:98291588-98292138 Neighboring gene microRNA 4495

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic variants associated with breast size also influence breast cancer risk.
    EBI GWAS Catalog

    General gene information

    Other Names

    • hsa-mir-135-2
    • hsa-mir-135a-2
    • microRNA 135-2

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in miRNA-mediated post-transcriptional gene silencing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of RISC complex IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_029678.1 RNA Sequence

      Status: PROVISIONAL

      Source sequence(s)
      AC018659
      Related
      ENST00000384854.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      97563812..97563911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      97536995..97537094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)