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    Kir3dl2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 [ Mus musculus (house mouse) ]

    Gene ID: 245615, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kir3dl2provided by MGI
    Official Full Name
    killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2provided by MGI
    Primary source
    MGI:MGI:3612791
    See related
    Ensembl:ENSMUSG00000057439 AllianceGenome:MGI:3612791
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kirl2
    Summary
    Predicted to enable several functions, including MHC class Ib protein binding activity; MHC class Ib receptor activity; and identical protein binding activity. Predicted to be involved in immune response-regulating signaling pathway. Predicted to be located in early endosome membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Polyomavirus-associated nephropathy; West Nile fever; human immunodeficiency virus infectious disease (multiple); liver disease (multiple); and tuberculosis (multiple). Orthologous to several human genes including KIR3DL1 (killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1) and KIR3DL2 (killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Kir3dl2 in Genome Data Viewer
    Location:
    X F1; X 58.45 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (135348676..135444826, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136447927..136544077, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA alanine 5 (anticodon CGC) Neighboring gene nuclear encoded tRNA alanine 4 (anticodon TGC) Neighboring gene predicted gene 14991 Neighboring gene killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 Neighboring gene presenilin associated, rhomboid-like pseudogene Neighboring gene nuclear encoded tRNA alanine 3 (anticodon TGC)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of a killer cell receptor-like gene in plastic regions of the central nervous system. Bryceson YT, et al. J Neuroimmunol, 2005 Apr. PMID 15748957
    2. Identification of the mouse killer immunoglobulin-like receptor-like (Kirl) gene family mapping to chromosome X. Welch AY, et al. Immunogenetics, 2003 Feb. PMID 12618911
    3. Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis. Song S, et al. Nat Med, 2016 Apr. PMID 26928464, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of a single MHCI molecule, HLA-F, protects human MNs from ALS astrocyte-mediated toxicity, whereas knockdown of its receptor, the killer cell immunoglobulin-like receptor KIR3DL2, on human astrocytes results in enhanced MN death.
      Title: Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis.
    2. encodes a KIR-like molecule with three Ig-like domains and lacks tyrosine-based immunoregulatory motifs in its cytoplasmic region
      Title: Identification of the mouse killer immunoglobulin-like receptor-like (Kirl) gene family mapping to chromosome X.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class Ib protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MHC class Ib receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
    Names
    KIR-like receptor 2
    killer immunoglobulin-like receptor-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177748.2 → NP_808416.1  killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 precursor

      See identical proteins and their annotated locations for NP_808416.1

      Status: PROVISIONAL

      Source sequence(s)
      AF548540
      Consensus CDS
      CCDS41133.1
      UniProtKB/Swiss-Prot
      P83555
      UniProtKB/TrEMBL
      D3YWF2, Q673W2, Q673W3
      Related
      ENSMUSP00000071994.6, ENSMUST00000072125.6
      Conserved Domains (2) summary
      smart00410
      Location:35 → 95
      IG_like; Immunoglobulin like
      cl11960
      Location:121 → 217
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      135348676..135444826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528538.3 → XP_006528601.1  killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 isoform X1

      UniProtKB/Swiss-Prot
      P83555
      UniProtKB/TrEMBL
      Q673W3
      Conserved Domains (1) summary
      cl11960
      Location:21 → 108
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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