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    Rhox1 reproductive homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 385343, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rhox1provided by MGI
    Official Full Name
    reproductive homeobox 1provided by MGI
    Primary source
    MGI:MGI:3580237
    See related
    Ensembl:ENSMUSG00000071773 AllianceGenome:MGI:3580237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward placenta adult (RPKM 1.7) See more
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    Genomic context

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    See Rhox1 in Genome Data Viewer
    Location:
    X A3.3; X 21.63 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (36477457..36485911, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (37213804..37222258, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:34731294-34731403 Neighboring gene NADH:ubiquinone oxidoreductase subunit A1 Neighboring gene ring finger protein 113A1 Neighboring gene predicted gene 9 Neighboring gene reproductive homeobox 2A Neighboring gene reproductive homeobox 3A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A murine specific expansion of the Rhox cluster involved in embryonic stem cell biology is under natural selection. Jackson M, et al. BMC Genomics, 2006 Aug 17. PMID 16916441, Free PMC Article
    2. The Homeobox Transcription Factor RHOX10 Drives Mouse Spermatogonial Stem Cell Establishment. Song HW, et al. Cell Rep, 2016 Sep 27. PMID 27681428, Free PMC Article
    3. shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects. Song HW, et al. PLoS One, 2015. PMID 25790000, Free PMC Article
    4. The rhox homeobox gene family shows sexually dimorphic and dynamic expression during mouse embryonic gonad development. Daggag H, et al. Biol Reprod, 2008 Sep. PMID 18562707
    5. Rhox homeobox gene cluster: recent duplication of three family members. MacLean JA 2nd, et al. Genesis, 2006 Mar. PMID 16496311

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    reproductive homeobox 1
    Names
    reproductive homeobox on X chromosome 1
    reproductive homeobox on chromosome X, 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025084.2 → NP_001020255.2  reproductive homeobox 1

      See identical proteins and their annotated locations for NP_001020255.2

      Status: VALIDATED

      Source sequence(s)
      DQ058638
      Consensus CDS
      CCDS40929.1
      UniProtKB/TrEMBL
      B1APN4
      Related
      ENSMUSP00000110865.2, ENSMUST00000115210.2
      Conserved Domains (1) summary
      cd00086
      Location:184 → 220
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      36477457..36485911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541387.2 → XP_006541450.1  reproductive homeobox 1 isoform X2

      See identical proteins and their annotated locations for XP_006541450.1

      UniProtKB/TrEMBL
      Q4TU92
      Conserved Domains (1) summary
      cl00084
      Location:127 → 163
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    2. XM_011250971.1 → XP_011249273.1  reproductive homeobox 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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