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    Nrk Nik related kinase [ Mus musculus (house mouse) ]

    Gene ID: 27206, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nrkprovided by MGI
    Official Full Name
    Nik related kinaseprovided by MGI
    Primary source
    MGI:MGI:1351326
    See related
    Ensembl:ENSMUSG00000052854 AllianceGenome:MGI:1351326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nesk
    Summary
    Enables protein kinase activity. Acts upstream of or within several processes, including parturition; positive regulation of JNK cascade; and regulation of spongiotrophoblast cell proliferation. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; limb; musculature; and telencephalon. Orthologous to human NRK (Nik related kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in placenta adult (RPKM 93.3) and limb E14.5 (RPKM 16.7) See more
    Orthologs
    human all
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    Genomic context

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    See Nrk in Genome Data Viewer
    Location:
    X F1; X 61.15 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (137814980..137911281)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (138914231..139010532)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor accessory protein-like 2 Neighboring gene STARR-seq mESC enhancer starr_47984 Neighboring gene STARR-seq mESC enhancer starr_47985 Neighboring gene STARR-seq mESC enhancer starr_47986 Neighboring gene zinc finger protein 259 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47988 Neighboring gene zinc finger CCCH type containing 14 pseudogene Neighboring gene RIKEN cDNA 4930513O06 gene Neighboring gene STARR-seq mESC enhancer starr_47989 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis of Nrk gene-disrupted placental tissue cells explains physiological significance of NRK. Denda K, et al. BMC Res Notes, 2019 Nov 29. PMID 31783915, Free PMC Article
    2. Nik-related kinase regulates trophoblast proliferation and placental development by modulating AKT phosphorylation. Morioka Y, et al. PLoS One, 2017. PMID 28152035, Free PMC Article
    3. Deficiency of X-Linked Protein Kinase Nrk during Pregnancy Triggers Breast Tumor in Mice. Yanagawa T, et al. Am J Pathol, 2016 Oct. PMID 27634343
    4. NESK, a member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and is expressed during the late stages of embryogenesis. Nakano K, et al. J Biol Chem, 2000 Jul 7. PMID 10801798
    5. Nrk: a murine X-linked NIK (Nck-interacting kinase)-related kinase gene expressed in skeletal muscle. Kanai-Azuma M, et al. Mech Dev, 1999 Dec. PMID 10559491

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. protein expression profiles were analyzed in the Nrk-null placenta.
      Title: Proteomic analysis of Nrk gene-disrupted placental tissue cells explains physiological significance of NRK.
    2. The results suggest that Nrk suppresses the excessive proliferation of mammary epithelial cells during pregnancy, and the impairment of this regulatory system leads to frequent occurrence of breast tumor in Nrk mutant mice.
      Title: Deficiency of X-Linked Protein Kinase Nrk during Pregnancy Triggers Breast Tumor in Mice.
    3. regulates trophoblast proliferation and placental development by modulating AKT phosphorylation
      Title: Nik-related kinase regulates trophoblast proliferation and placental development by modulating AKT phosphorylation.
    4. Nrk, an X-linked protein kinase in the germinal center kinase family, is required for placental development and fetoplacental induction of labor.
      Title: Nrk, an X-linked protein kinase in the germinal center kinase family, is required for placental development and fetoplacental induction of labor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within parturition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of spongiotrophoblast cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nik-related protein kinase
    Names
    NIK-like embryo-specific kinase
    nck-interacting kinase-like embryo specific kinase
    NP_038752.2
    XP_006528613.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013724.2 → NP_038752.2  nik-related protein kinase

      See identical proteins and their annotated locations for NP_038752.2

      Status: VALIDATED

      Source sequence(s)
      BX324117, BX784027
      Consensus CDS
      CCDS41143.1
      UniProtKB/Swiss-Prot
      B2RSW5, Q6NV55, Q8C9S9, Q9R0G8, Q9R0S4
      UniProtKB/TrEMBL
      B1B0C9
      Related
      ENSMUSP00000063397.8, ENSMUST00000064937.14
      Conserved Domains (3) summary
      smart00220
      Location:25 → 313
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02434
      Location:1143 → 1422
      CNH; CNH domain
      cl21453
      Location:14 → 313
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      137814980..137911281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528550.4 → XP_006528613.1  nik-related protein kinase isoform X1

      UniProtKB/TrEMBL
      B1B0C9
      Related
      ENSMUSP00000115962.2, ENSMUST00000131829.2
      Conserved Domains (3) summary
      PRK10811
      Location:430 → 578
      rne; ribonuclease E; Reviewed
      cl02434
      Location:1143 → 1479
      CNH; CNH domain
      cl21453
      Location:14 → 313
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0G8.2 GenPept UniProtKB/Swiss-Prot:Q9R0G8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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