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    Psma4 proteasome subunit alpha 4 [ Mus musculus (house mouse) ]

    Gene ID: 26441, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Psma4provided by MGI
    Official Full Name
    proteasome subunit alpha 4provided by MGI
    Primary source
    MGI:MGI:1347060
    See related
    Ensembl:ENSMUSG00000032301 AllianceGenome:MGI:1347060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C9
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in P-body. Part of proteasome core complex. Is expressed in liver. Orthologous to human PSMA4 (proteasome 20S subunit alpha 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 71.5), CNS E11.5 (RPKM 59.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Psma4 in Genome Data Viewer
    Location:
    9 B; 9 29.84 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (54858074..54865316)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (54950781..54958034)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2292 Neighboring gene iron responsive element binding protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E1787 Neighboring gene hydroxylysine kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E6734 Neighboring gene cDNA sequence AY074887 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 5 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 3 Neighboring gene cholinergic receptor, nicotinic, beta polypeptide 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the testis-specific proteasome subunit α4s in mammals. Uechi H, et al. J Biol Chem, 2014 May 2. PMID 24668818, Free PMC Article
    2. Intracellular distribution of oxidized proteins and proteasome in HT22 cells during oxidative stress. Jung T, et al. Free Radic Biol Med, 2006 Apr 15. PMID 16631520
    3. Proteasome subunit α4s is essential for formation of spermatoproteasomes and histone degradation during meiotic DNA repair in spermatocytes. Zhang ZH, et al. J Biol Chem, 2021 Jan-Jun. PMID 33262216, Free PMC Article
    4. Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice. Zhang Y, et al. Int J Biochem Cell Biol, 2023 Jun. PMID 37116777
    5. c-Fos proteasomal degradation is activated by a default mechanism, and its regulation by NAD(P)H:quinone oxidoreductase 1 determines c-Fos serum response kinetics. Adler J, et al. Mol Cell Biol, 2010 Aug. PMID 20498278, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice.
      Title: Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice.
    2. Proteasome subunit alpha4s is essential for formation of spermatoproteasomes and histone degradation during meiotic DNA repair in spermatocytes.
      Title: Proteasome subunit α4s is essential for formation of spermatoproteasomes and histone degradation during meiotic DNA repair in spermatocytes.
    3. Data indicate that proteasome subunit alpha4 (alpha4s) is exclusively expressed in germ cells that enter the meiotic prophase.
      Title: Characterization of the testis-specific proteasome subunit α4s in mammals.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proteasome subunit alpha type-4
    Names
    alpha-3
    macropain subunit C9
    multicatalytic endopeptidase complex subunit C9
    proteasome (prosome, macropain) subunit, alpha type 4
    proteasome component C9
    proteasome subunit L
    proteasome subunit alpha-3
    NP_001396620.1
    NP_001396621.1
    NP_036096.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001409691.1 → NP_001396620.1  proteasome subunit alpha type-4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC161264
      UniProtKB/Swiss-Prot
      Q3THT1, Q9R1P0
      UniProtKB/TrEMBL
      Q3TL95
      Related
      ENSMUSP00000126844.2, ENSMUST00000172407.8

    2. NM_001409692.1 → NP_001396621.1  proteasome subunit alpha type-4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161264
      UniProtKB/TrEMBL
      Q3TL95

    3. NM_011966.4 → NP_036096.1  proteasome subunit alpha type-4 isoform 1

      See identical proteins and their annotated locations for NP_036096.1

      Status: VALIDATED

      Source sequence(s)
      AC161264
      Consensus CDS
      CCDS40643.1
      UniProtKB/Swiss-Prot
      Q3THT1, Q9R1P0
      UniProtKB/TrEMBL
      Q3TL95
      Related
      ENSMUSP00000034848.8, ENSMUST00000034848.14
      Conserved Domains (1) summary
      cd03752
      Location:3 → 216
      proteasome_alpha_type_4; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      54858074..54865316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R1P0.1 GenPept UniProtKB/Swiss-Prot:Q9R1P0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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