Arhgap33 Rho GTPase activating protein 33 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap33provided by MGI
Official Full Name: Rho GTPase activating protein 33provided by MGI
Primary source: MGI:MGI:2673998
See related: Ensembl:ENSMUSG00000036882 AllianceGenome:MGI:2673998
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Snx26; TCGAP; NOMA-GAP
Summary: Enables GTPase activator activity. Involved in regulation of postsynapse assembly. Located in cytoplasm and plasma membrane. Is active in glutamatergic synapse. Is expressed in brain; parathyroid gland; peripheral nervous system; and prostate gland. Orthologous to human ARHGAP33 (Rho GTPase activating protein 33). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in whole brain E14.5 (RPKM 45.7), CNS E14 (RPKM 41.4) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 18.43 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (30221651..30234596, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30522225..30535171, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission.
Title: Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission.
ARHGAP33 interacts with SORT1 to cooperatively regulate TrkB trafficking. ARHGAP33 KO mice exhibit reduced expression of synaptic TrkB, impaired dendritic spine development and neuropsychiatric disorder-related behavioural abnormalities.
Title: Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders.
Results indicate that SNX26 interacts with PSD-95 and regulates formation of dendritic spines.
Title: SNX26, a GTPase-activating protein for Cdc42, interacts with PSD-95 protein and is involved in activity-dependent dendritic spine formation in mature neurons.
Cofilin activation during late cortical development depended on NOMA-GAP expression and subsequent inhibition of Cdc42. In utero expression of active cofilin was sufficient to restore postnatal dendritic complexity in NOMA-GAP-deficient animals.
Title: Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin.
Overexpression of the full-length and C-terminal fragments of TCGAP inhibits insulin-stimulated glucose uptake and GLUT4 translocation.
Title: TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW324378 (e-PCR)
- UniSTS:179549

UniSTS:235645 (e-PCR)
- UniSTS:235645

RH132495 (e-PCR)
- UniSTS:215778

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in fibrillar center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 33

Names: TC10/CDC42 GTPase-activating protein; rho-type GTPase-activating protein 33; sorting nexin 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289670.1 → NP_001276599.1 rho GTPase-activating protein 33 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon that includes a portion of the 5' UTR and 5' coding region, resulting in translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

AK142180, BC065086

Consensus CDS

CCDS85264.1

UniProtKB/TrEMBL

A0A140LHW2, A0A2X0SFM8

Related

ENSMUSP00000146571.2, ENSMUST00000207858.2

Conserved Domains (3) summary

cd11835
Location:190 → 243

SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins

cd04384
Location:311 → 505

RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

cl02563
Location:56 → 168

PX_domain; The Phox Homology domain, a phosphoinositide binding module
NM_001289682.1 → NP_001276611.1 rho GTPase-activating protein 33 isoform a

See identical proteins and their annotated locations for NP_001276611.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode isoform a.

Source sequence(s)

AK142180, BC066047

Consensus CDS

CCDS21095.1

UniProtKB/Swiss-Prot

Q6P7W6, Q80YF9

UniProtKB/TrEMBL

A0A2X0SFM8

Related

ENSMUSP00000146767.2, ENSMUST00000208538.2

Conserved Domains (3) summary

cd11835
Location:214 → 267

SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins

cd04384
Location:335 → 529

RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...

cl02563
Location:80 → 192

PX_domain; The Phox Homology domain, a phosphoinositide binding module
NM_178252.3 → NP_839983.1 rho GTPase-activating protein 33 isoform a

See identical proteins and their annotated locations for NP_839983.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform.

Source sequence(s)

AK142180, BC065086

Consensus CDS

CCDS21095.1

UniProtKB/Swiss-Prot

Q6P7W6, Q80YF9

UniProtKB/TrEMBL

A0A2X0SFM8

Related

ENSMUSP00000146602.2, ENSMUST00000207860.2

Conserved Domains (3) summary

cd11835
Location:214 → 267

SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins

cd04384
Location:335 → 529

RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...

cl02563
Location:80 → 192

PX_domain; The Phox Homology domain, a phosphoinositide binding module