N4bp2l2 NEDD4 binding protein 2-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: N4bp2l2provided by MGI
Official Full Name: NEDD4 binding protein 2-like 2provided by MGI
Primary source: MGI:MGI:2687207
See related: Ensembl:ENSMUSG00000029655 AllianceGenome:MGI:2687207
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: zag1; Gm38758; 2700092H06Rik
Summary: Enables transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within blastocyst development. Located in nucleus. Orthologous to human N4BP2L2 (NEDD4 binding protein 2 like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 3.7), CNS E18 (RPKM 3.4) and 25 other tissues See more
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Genomic context

Location:: 5; 5 G3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (150515310..150589213, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (150599931..150665748, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

increased Zag expression in the aged kidney acts to suppress the proliferative response to injury
Title: Zag expression during aging suppresses proliferation after kidney injury.
results suggest that ZAG1 may be closely associated with zygotic gene expression in mouse preimplantation embryos
Title: Identification of ZAG1, a novel protein expressed in mouse preimplantation, and its putative roles in zygotic genome activation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

NoName (e-PCR)
- UniSTS:235379

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hematopoietic stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hematopoietic stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hematopoietic stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hematopoietic stem cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	IEA Inferred from Electronic Annotation more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NEDD4-binding protein 2-like 2

Names: phosphonoformate immuno-associated protein 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362416.1 → NP_001349345.1 NEDD4-binding protein 2-like 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC158558, AK038740, BC062895

Conserved Domains (1) summary

pfam13671
Location:396 → 529

AAA_33; AAA domain
NM_201369.3 → NP_958757.2 NEDD4-binding protein 2-like 2 isoform 2

See identical proteins and their annotated locations for NP_958757.2

Status: VALIDATED

Source sequence(s)

AC158558, AK038740, AW488478, CA556104, CB231597, CD561511, CF724618, CJ162163

Consensus CDS

CCDS19888.2

UniProtKB/Swiss-Prot

Q8JZS6

Related

ENSMUSP00000113895.2, ENSMUST00000118316.8

Conserved Domains (2) summary

pfam13671
Location:396 → 529

AAA_33; AAA domain

cl17190
Location:396 → 526

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

150515310..150589213 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254630.2 → XP_030110490.1 NEDD4-binding protein 2-like 2 isoform X1

Conserved Domains (1) summary

pfam13671
Location:396 → 529

AAA_33; AAA domain
XM_030254629.2 → XP_030110489.1 NEDD4-binding protein 2-like 2 isoform X1

Conserved Domains (1) summary

pfam13671
Location:396 → 529

AAA_33; AAA domain
XM_036165248.1 → XP_036021141.1 NEDD4-binding protein 2-like 2 isoform X1

Conserved Domains (1) summary

pfam13671
Location:396 → 529

AAA_33; AAA domain
XM_036165249.1 → XP_036021142.1 NEDD4-binding protein 2-like 2 isoform X1

Conserved Domains (1) summary

pfam13671
Location:396 → 529

AAA_33; AAA domain
XM_036165251.1 → XP_036021144.1 NEDD4-binding protein 2-like 2 isoform X1

Conserved Domains (1) summary

pfam13671
Location:396 → 529

AAA_33; AAA domain
XM_036165252.1 → XP_036021145.1 NEDD4-binding protein 2-like 2 isoform X2

Conserved Domains (1) summary

pfam13671
Location:17 → 93

AAA_33; AAA domain