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    Tmem74b transmembrane protein 74B [ Mus musculus (house mouse) ]

    Gene ID: 108832, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem74bprovided by MGI
    Official Full Name
    transmembrane protein 74Bprovided by MGI
    Primary source
    MGI:MGI:1918629
    See related
    Ensembl:ENSMUSG00000044364 AllianceGenome:MGI:1918629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5430405G05Rik
    Summary
    Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human TMEM74B (transmembrane protein 74B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 2.6), whole brain E14.5 (RPKM 2.2) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem74b in Genome Data Viewer
    Location:
    2 G3; 2 74.83 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (151543294..151558665)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (151701805..151716745)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RAD21-like (S. pombe) Neighboring gene transmembrane 74B, opposite strand Neighboring gene STARR-seq mESC enhancer starr_06033 Neighboring gene proteasome (prosome, macropain) inhibitor subunit 1 Neighboring gene RIKEN cDNA 4930556L07 gene Neighboring gene heterogeneous nuclear ribonucleoprotein H1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 74B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160363.2 → NP_001153835.1  transmembrane protein 74B

      See identical proteins and their annotated locations for NP_001153835.1

      Status: VALIDATED

      Source sequence(s)
      AL928988
      Consensus CDS
      CCDS50748.1
      UniProtKB/TrEMBL
      A2AU34
      Related
      ENSMUSP00000060017.3, ENSMUST00000060196.3
      Conserved Domains (2) summary
      pfam14927
      Location:99 → 164
      Neurensin; Neurensin
      cl00278
      Location:73 → 123
      CCC1_like; CCC1-related family of proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      151543294..151558665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314899.3 → XP_017170388.1  transmembrane protein 74B isoform X2

      UniProtKB/TrEMBL
      A2AU34

    2. XM_006498562.4 → XP_006498625.1  transmembrane protein 74B isoform X2

      See identical proteins and their annotated locations for XP_006498625.1

      UniProtKB/TrEMBL
      A2AU34
      Related
      ENSMUSP00000105498.2, ENSMUST00000109872.2
      Conserved Domains (2) summary
      pfam14927
      Location:99 → 164
      Neurensin; Neurensin
      cl00278
      Location:73 → 123
      CCC1_like; CCC1-related family of proteins

    3. XM_006498564.5 → XP_006498627.1  transmembrane protein 74B isoform X2

      See identical proteins and their annotated locations for XP_006498627.1

      UniProtKB/TrEMBL
      A2AU34
      Conserved Domains (2) summary
      pfam14927
      Location:99 → 164
      Neurensin; Neurensin
      cl00278
      Location:73 → 123
      CCC1_like; CCC1-related family of proteins

    4. XM_036157424.1 → XP_036013317.1  transmembrane protein 74B isoform X1

      UniProtKB/TrEMBL
      Q8BRL3

    5. XM_006498563.5 → XP_006498626.1  transmembrane protein 74B isoform X2

      See identical proteins and their annotated locations for XP_006498626.1

      UniProtKB/TrEMBL
      A2AU34
      Conserved Domains (2) summary
      pfam14927
      Location:99 → 164
      Neurensin; Neurensin
      cl00278
      Location:73 → 123
      CCC1_like; CCC1-related family of proteins

    6. XM_036157427.1 → XP_036013320.1  transmembrane protein 74B isoform X2

      UniProtKB/TrEMBL
      A2AU34
    Nucleotide Protein Strain
    Heading Accession and Version

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