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    Cyp4f13 cytochrome P450, family 4, subfamily f, polypeptide 13 [ Mus musculus (house mouse) ]

    Gene ID: 170716, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4f13provided by MGI
    Official Full Name
    cytochrome P450, family 4, subfamily f, polypeptide 13provided by MGI
    Primary source
    MGI:MGI:2158641
    See related
    Ensembl:ENSMUSG00000024055 AllianceGenome:MGI:2158641
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cypf13; 0610030I10Rik
    Summary
    Predicted to enable monooxygenase activity. Predicted to be involved in fatty acid metabolic process. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human CYP4F3 (cytochrome P450 family 4 subfamily F member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 29.8), liver adult (RPKM 28.4) and 27 other tissues See more
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    Genomic context

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    See Cyp4f13 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33143662..33166389, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32924688..32947415, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42397 Neighboring gene zinc finger protein 870 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33028261-33028519 Neighboring gene STARR-seq mESC enhancer starr_42399 Neighboring gene STARR-seq mESC enhancer starr_42400 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 14 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33084248-33084483 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 41 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7516 Neighboring gene zinc finger protein 472

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Confirmation of Ath26 locus on chromosome 17 and identification of Cyp4f13 as an atherosclerosis modifying gene. Han J, et al. Atherosclerosis, 2019 Jul. PMID 31102955, Free PMC Article
    2. Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues. Choudhary D, et al. Arch Biochem Biophys, 2003 Jun 1. PMID 12745259
    3. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 20-aldehyde-leukotriene B4 20-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 20-hydroxy-leukotriene B4 omega oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leukotriene-B4 20-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid omega-1 hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables very long-chain fatty acid omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid omega-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene B4 catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipoxin A4 metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipoxin B4 metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in omega-hydroxylase P450 pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 4, subfamily f, polypeptide 13
    Names
    P450 CYP4F13
    cytochrome P450 CYP4F13
    cytochrome P450,subfamily IVF, polypeptide 13
    leukotriene B4 omega hydroxylase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417675.1 → NP_001404604.1  cytochrome P450, family 4, subfamily f, polypeptide 13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT033772
      UniProtKB/TrEMBL
      B8JK07

    2. NM_001417676.1 → NP_001404605.1  cytochrome P450, family 4, subfamily f, polypeptide 13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT033772
      UniProtKB/TrEMBL
      B8JK07

    3. NM_001417677.1 → NP_001404606.1  cytochrome P450, family 4, subfamily f, polypeptide 13 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT033772
      UniProtKB/TrEMBL
      Q99KY6

    4. NM_001417678.1 → NP_001404607.1  cytochrome P450, family 4, subfamily f, polypeptide 13 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT033772
      UniProtKB/TrEMBL
      Q99KY6

    5. NM_130882.2 → NP_570952.1  cytochrome P450, family 4, subfamily f, polypeptide 13 isoform 1

      See identical proteins and their annotated locations for NP_570952.1

      Status: VALIDATED

      Source sequence(s)
      CT033772
      Consensus CDS
      CCDS28622.1
      UniProtKB/TrEMBL
      Q99KY6, Q99N19
      Related
      ENSMUSP00000074733.7, ENSMUST00000075253.13
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 513
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      33143662..33166389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523736.4 → XP_006523799.1  cytochrome P450, family 4, subfamily f, polypeptide 13 isoform X3

      See identical proteins and their annotated locations for XP_006523799.1

      UniProtKB/TrEMBL
      B8JK07
      Conserved Domains (1) summary
      pfam00067
      Location:45 → 372
      p450; Cytochrome P450

    2. XM_006523737.4 → XP_006523800.1  cytochrome P450, family 4, subfamily f, polypeptide 13 isoform X3

      See identical proteins and their annotated locations for XP_006523800.1

      UniProtKB/TrEMBL
      B8JK07
      Conserved Domains (1) summary
      pfam00067
      Location:45 → 372
      p450; Cytochrome P450

    3. XM_006523738.3 → XP_006523801.1  cytochrome P450, family 4, subfamily f, polypeptide 13 isoform X4

      Conserved Domains (1) summary
      cl12078
      Location:52 → 374
      p450; Cytochrome P450
    Nucleotide Protein Strain
    Heading Accession and Version

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