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    Rasal3 RAS protein activator like 3 [ Mus musculus (house mouse) ]

    Gene ID: 320484, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rasal3provided by MGI
    Official Full Name
    RAS protein activator like 3provided by MGI
    Primary source
    MGI:MGI:2444128
    See related
    Ensembl:ENSMUSG00000052142 AllianceGenome:MGI:2444128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A430107D22Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in negative regulation of Ras protein signal transduction and positive regulation of NK T cell proliferation. Predicted to be located in cytoplasm and cytoplasmic side of membrane. Is expressed in thymus primordium. Orthologous to human RASAL3 (RAS protein activator like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 113.1), spleen adult (RPKM 50.6) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Rasal3 in Genome Data Viewer
    Location:
    17 B1; 17 17.55 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32609633..32622586, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32390659..32403582, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E955 Neighboring gene A kinase anchor protein 8-like Neighboring gene STARR-positive B cell enhancer ABC_E1502 Neighboring gene STARR-positive B cell enhancer mm9_chr17:32506256-32506557 Neighboring gene STARR-positive B cell enhancer mm9_chr17:32508595-32508896 Neighboring gene widely-interspaced zinc finger motifs Neighboring gene STARR-positive B cell enhancer ABC_E4205 Neighboring gene RIKEN cDNA A530088E08 gene Neighboring gene predicted gene, 53995 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:32540440-32540643 Neighboring gene predicted gene, 41569 Neighboring gene peptidoglycan recognition protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:32561046-32561233 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 39

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rasal3-mediated T cell survival is essential for inflammatory responses. Muro R, et al. Biochem Biophys Res Commun, 2018 Jan 29. PMID 29291408
    2. The Ras GTPase-activating protein Rasal3 supports survival of naive T cells. Muro R, et al. PLoS One, 2015. PMID 25793935, Free PMC Article
    3. CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis. Olivier JF, et al. Commun Biol, 2024 Jan 10. PMID 38200184, Free PMC Article
    4. RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils. Saito S, et al. Front Immunol, 2021. PMID 34777356, Free PMC Article
    5. RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells. Saito S, et al. Eur J Immunol, 2015 May. PMID 25652366

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis.
      Title: CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis.
    2. RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils.
      Title: RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils.
    3. Collectively, Rasal3 controls the magnitude of inflammatory responses through the survival of both naive T cells and activated T cells in vivo.
      Title: Rasal3-mediated T cell survival is essential for inflammatory responses.
    4. Rasal3 is required for in vivo survival of peripheral naive T cells, contributing to the maintenance of optimal T cell numbers.
      Title: The Ras GTPase-activating protein Rasal3 supports survival of naive T cells.
    5. results suggest that RASAL3 plays an important role in the expansion and functions of NKT cells in the liver by negatively regulating Ras/Erk signaling
      Title: RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of NK T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of NK T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RAS protein activator like-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347343.2 → NP_001334272.1  RAS protein activator like-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT485616
      Consensus CDS
      CCDS84292.1
      UniProtKB/TrEMBL
      Q6KAS9
      Related
      ENSMUSP00000123141.2, ENSMUST00000137458.2

    2. NM_001374604.1 → NP_001361533.1  RAS protein activator like-3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT485616
      UniProtKB/TrEMBL
      D3Z6Z7, Q6KAS9
      Related
      ENSMUSP00000116107.2, ENSMUST00000135618.8
      Conserved Domains (3) summary
      cd05136
      Location:424 → 747
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cl14603
      Location:300 → 432
      C2; C2 domain
      cl17171
      Location:181 → 326
      PH-like; Pleckstrin homology-like domain

    3. NM_001400382.1 → NP_001387311.1  RAS protein activator like-3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT485616
      UniProtKB/TrEMBL
      Q6KAS9

    4. NM_178785.5 → NP_848900.2  RAS protein activator like-3 isoform 2

      See identical proteins and their annotated locations for NP_848900.2

      Status: VALIDATED

      Source sequence(s)
      CT485616
      Consensus CDS
      CCDS37556.1
      UniProtKB/Swiss-Prot
      A3KMM0, Q8C2A5, Q8C2K5, Q8C9R4, Q8CDB4
      UniProtKB/TrEMBL
      Q6KAS9
      Related
      ENSMUSP00000064084.8, ENSMUST00000063824.14
      Conserved Domains (3) summary
      cd05136
      Location:446 → 769
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cl14603
      Location:322 → 454
      C2; C2 domain
      cl17171
      Location:203 → 348
      PH-like; Pleckstrin homology-like domain

    RNA

    1. NR_153797.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT485616

    2. NR_174479.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT485616

    3. NR_174480.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT485616

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      32609633..32622586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524412.5 → XP_006524475.1  RAS protein activator like-3 isoform X1

      UniProtKB/TrEMBL
      Q6KAS9
      Conserved Domains (3) summary
      cd05136
      Location:470 → 793
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cl14603
      Location:346 → 478
      C2; C2 domain
      cl17171
      Location:227 → 372
      PH-like; Pleckstrin homology-like domain

    2. XM_030249844.2 → XP_030105704.1  RAS protein activator like-3 isoform X3

      UniProtKB/TrEMBL
      A0A0R4J1U7
      Related
      ENSMUSP00000118738.2, ENSMUST00000136375.8
      Conserved Domains (3) summary
      cl02569
      Location:446 → 600
      RasGAP; Ras GTPase Activating Domain
      cl14603
      Location:322 → 454
      C2; C2 domain
      cl17171
      Location:203 → 348
      PH-like; Pleckstrin homology-like domain

    3. XM_011246497.3 → XP_011244799.1  RAS protein activator like-3 isoform X2

      UniProtKB/TrEMBL
      A0A0R4J1U7
      Conserved Domains (3) summary
      cl02569
      Location:470 → 624
      RasGAP; Ras GTPase Activating Domain
      cl14603
      Location:346 → 478
      C2; C2 domain
      cl17171
      Location:227 → 372
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_385337.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C2K5.1 GenPept UniProtKB/Swiss-Prot:Q8C2K5

    Gene LinkOut

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