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    Robo2 roundabout guidance receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 268902, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Robo2provided by MGI
    Official Full Name
    roundabout guidance receptor 2provided by MGI
    Primary source
    MGI:MGI:1890110
    See related
    Ensembl:ENSMUSG00000052516 AllianceGenome:MGI:1890110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1568; 2600013A04Rik; 9430089E08Rik; D230004I22Rik
    Summary
    Predicted to enable axon guidance receptor activity and identical protein binding activity. Involved in several processes, including circulatory system development; neuron development; and positive regulation of Notch signaling pathway. Acts upstream of or within axon guidance and metanephros development. Located in axolemma. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including autopod; central nervous system; embryo mesenchyme; jaw; and urinary system. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human ROBO2 (roundabout guidance receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 11.3), whole brain E14.5 (RPKM 10.4) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Robo2 in Genome Data Viewer
    Location:
    16 C3.1; 16 42.17 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (73688725..75244331, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (73891976..75447443, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41245 Neighboring gene predicted gene, 41472 Neighboring gene STARR-seq mESC enhancer starr_41247 Neighboring gene STARR-seq mESC enhancer starr_41248 Neighboring gene STARR-seq mESC enhancer starr_41249 Neighboring gene olfactory receptor 818 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41252 Neighboring gene STARR-seq mESC enhancer starr_41253 Neighboring gene STARR-seq mESC enhancer starr_41254 Neighboring gene STARR-seq mESC enhancer starr_41256 Neighboring gene predicted gene, 22163 Neighboring gene STARR-seq mESC enhancer starr_41258 Neighboring gene STARR-seq mESC enhancer starr_41259 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41260 Neighboring gene microRNA 691 Neighboring gene STARR-seq mESC enhancer starr_41261 Neighboring gene predicted gene, 26307 Neighboring gene predicted gene, 52242 Neighboring gene STARR-seq mESC enhancer starr_41262 Neighboring gene predicted gene, 57634 Neighboring gene STARR-seq mESC enhancer starr_41263 Neighboring gene STARR-seq mESC enhancer starr_41264 Neighboring gene predicted gene, 52278 Neighboring gene STARR-seq mESC enhancer starr_41265 Neighboring gene STARR-seq mESC enhancer starr_41266 Neighboring gene STARR-seq mESC enhancer starr_41267 Neighboring gene nuclear encoded tRNA isoleucine 1 (anticodon AAT) Neighboring gene RNA binding motif protein 11 Neighboring gene lipase, member I

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Islet architecture in adult mice is actively maintained by Robo2 expression in β cells. Waters BJ, et al. Dev Biol, 2024 Jan. PMID 37972678,
    2. New congenital anomalies of the kidney and urinary tract and outcomes in Robo2 mutant mice with the inserted piggyBac transposon. Liu J, et al. BMC Nephrol, 2016 Jul 26. PMID 27460642, Free PMC Article
    3. Intrauterine low-protein diet aggravates developmental abnormalities of the urinary system via the Akt/Creb3 pathway in Robo2 mutant mice. Yu M, et al. Am J Physiol Renal Physiol, 2020 Jan 1. PMID 31630547
    4. Robo2 promotes osteoblast differentiation and mineralization through autophagy and is activated by parathyroid hormone induction. Yuan N, et al. Ann Anat, 2023 Jun. PMID 36801365
    5. Overexpression of Robo2 causes defects in the recruitment of metanephric mesenchymal cells and ureteric bud branching morphogenesis. Ji J, et al. Biochem Biophys Res Commun, 2012 May 11. PMID 22521888

    See all (222) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Islet architecture in adult mice is actively maintained by Robo2 expression in beta cells.
      Title: Islet architecture in adult mice is actively maintained by Robo2 expression in β cells.
    2. Robo2 promotes osteoblast differentiation and mineralization through autophagy and is activated by parathyroid hormone induction.
      Title: Robo2 promotes osteoblast differentiation and mineralization through autophagy and is activated by parathyroid hormone induction.
    3. Inhibition of MAPK/ERK pathway activation rescues congenital anomalies of the kidney and urinary tract (CAKUT) in Robo2[PB/+] Gen1[PB/+] mice.
      Title: Inhibition of MAPK/ERK pathway activation rescues congenital anomalies of the kidney and urinary tract (CAKUT) in Robo2(PB/+) Gen1(PB/+) mice.
    4. Soluble TREM-1, as a new ligand for the membrane receptor Robo2, promotes hepatic stellate cells activation and liver fibrosis.
      Title: Soluble TREM-1, as a new ligand for the membrane receptor Robo2, promotes hepatic stellate cells activation and liver fibrosis.
    5. Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function.
      Title: Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function.
    6. Slit2-Robo Signaling Promotes Glomerular Vascularization and Nephron Development.
      Title: Slit2-Robo Signaling Promotes Glomerular Vascularization and Nephron Development.
    7. ROBO2-mediated RALDH2 signaling is required for common nephric duct fusion with primitive bladder.
      Title: ROBO2-mediated RALDH2 signaling is required for common nephric duct fusion with primitive bladder.
    8. Disruption of Robo2-Baiap2 integrated signaling drives cystic disease.
      Title: Disruption of Robo2-Baiap2 integrated signaling drives cystic disease.
    9. investigation of how Slit/Robo signals are involved in preventing emigrant motor neurons in the spinal cord
      Title: Slit/Robo signals prevent spinal motor neuron emigration by organizing the spinal cord basement membrane.
    10. Here, the report that mammalian ROBO1 and ROBO2 are not uniformly inhibited precrossing and are instead subject to additional temporal control via alternative splicing at a conserved microexon. Postcrossing, the ROBO1 and ROBO2 isoforms are disinhibited to prevent midline reentry and to guide postcrossing commissural axons to distinct mediolateral positions.
      Title: Temporal regulation of axonal repulsion by alternative splicing of a conserved microexon in mammalian Robo1 and Robo2.
    Submit: New GeneRIF Correction See all GeneRIFs (56)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables axon guidance receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in aorta development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in aortic valve morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in axon midline choice point recognition IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocardial cushion formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heart induction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within metanephros development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of negative chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in olfactory bulb interneuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in outflow tract septum morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pulmonary valve morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in retinal ganglion cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ureteric bud development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ureteric bud development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ventricular septum morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axolemma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    roundabout homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358490.2 → NP_001345419.1  roundabout homolog 2 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC112155, AC122049, AC129186, AC134452, AC158234, AC162374
      UniProtKB/TrEMBL
      Q19AB3
      Conserved Domains (5) summary
      cd05726
      Location:347 → 436
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:45 → 144
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:443 → 524
      IG_like; Immunoglobulin like
      cd00063
      Location:541 → 634
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:152 → 236
      Ig; Immunoglobulin domain

    2. NM_001358491.2 → NP_001345420.1  roundabout homolog 2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC112155, AC115120, AC122049, AC134452, AC158234, AC162374
      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:355 → 444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451 → 532
      IG_like; Immunoglobulin like
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    3. NM_001358492.2 → NP_001345421.1  roundabout homolog 2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC112155, AC115120, AC122049, AC134452, AC158234, AC162374
      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (5) summary
      cd05726
      Location:355 → 444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451 → 532
      IG_like; Immunoglobulin like
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    4. NM_001358493.2 → NP_001345422.1  roundabout homolog 2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC112155, AC115120, AC122049, AC134452, AC158234, AC162374
      UniProtKB/TrEMBL
      A0A2I3BR72, A0AAQ4VMV1
      Related
      ENSMUSP00000160011.1, ENSMUST00000249913.1
      Conserved Domains (5) summary
      cd05726
      Location:355 → 444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451 → 532
      IG_like; Immunoglobulin like
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    5. NM_001358494.2 → NP_001345423.1  roundabout homolog 2 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC112155, AC122049, AC134452, AC158234, AC162374
      UniProtKB/TrEMBL
      E9Q6A0
      Related
      ENSMUSP00000112285.5, ENSMUST00000116586.5
      Conserved Domains (5) summary
      cd05726
      Location:332 → 421
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:30 → 129
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:428 → 509
      IG_like; Immunoglobulin like
      cd00063
      Location:526 → 619
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:137 → 221
      Ig; Immunoglobulin domain

    6. NM_001415036.1 → NP_001401965.1  roundabout homolog 2 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC112155, AC122049, AC134452, AC158234, AC162374
      Related
      ENSMUSP00000113795.2, ENSMUST00000117200.8

    7. NM_001415039.1 → NP_001401968.1  roundabout homolog 2 isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      AC112155, AC122049, AC134452, AC158234, AC162374
      UniProtKB/Swiss-Prot
      Q7TPD3, Q8BJ59
      Related
      ENSMUSP00000154010.3, ENSMUST00000227347.3

    8. NM_175549.6 → NP_780758.3  roundabout homolog 2 isoform 5 precursor

      See identical proteins and their annotated locations for NP_780758.3

      Status: VALIDATED

      Source sequence(s)
      AC112155, AC122049, AC134452, AC158234, AC162374
      Consensus CDS
      CCDS49886.1
      UniProtKB/TrEMBL
      A0A2I3BR72, Q19AB2
      Related
      ENSMUSP00000112776.2, ENSMUST00000117785.9
      Conserved Domains (7) summary
      cd00096
      Location:435 → 502
      Ig; Immunoglobulin domain
      cd05726
      Location:328 → 417
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:30 → 129
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:424 → 505
      IG_like; Immunoglobulin like
      cd00063
      Location:522 → 615
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:225 → 310
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:137 → 221
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      73688725..75244331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159959.1 → XP_036015852.1  roundabout homolog 2 isoform X5

      UniProtKB/TrEMBL
      Q19AB3
      Conserved Domains (6) summary
      cd00063
      Location:537 → 630
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:151 → 154
      Ig; Ig strand A [structural motif]
      cd05726
      Location:330 → 427
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:46 → 144
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:434 → 520
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:151 → 236
      Ig; Immunoglobulin domain

    2. XM_006523038.4 → XP_006523101.1  roundabout homolog 2 isoform X4

      UniProtKB/TrEMBL
      Q19AB3
      Conserved Domains (5) summary
      cd05726
      Location:347 → 436
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:45 → 144
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:443 → 524
      IG_like; Immunoglobulin like
      cd00063
      Location:541 → 634
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:152 → 236
      Ig; Immunoglobulin domain

    3. XM_030249139.1 → XP_030104999.1  roundabout homolog 2 isoform X4

      UniProtKB/TrEMBL
      Q19AB3
      Conserved Domains (5) summary
      cd05726
      Location:347 → 436
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:45 → 144
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:443 → 524
      IG_like; Immunoglobulin like
      cd00063
      Location:541 → 634
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:152 → 236
      Ig; Immunoglobulin domain

    4. XM_030249140.1 → XP_030105000.1  roundabout homolog 2 isoform X4

      UniProtKB/TrEMBL
      Q19AB3
      Conserved Domains (5) summary
      cd05726
      Location:347 → 436
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:45 → 144
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:443 → 524
      IG_like; Immunoglobulin like
      cd00063
      Location:541 → 634
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:152 → 236
      Ig; Immunoglobulin domain

    5. XM_006523049.5 → XP_006523112.1  roundabout homolog 2 isoform X24

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (5) summary
      cd05726
      Location:351 → 440
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:447 → 528
      IG_like; Immunoglobulin like
      cd00063
      Location:545 → 638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    6. XM_036159962.1 → XP_036015855.1  roundabout homolog 2 isoform X16

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (6) summary
      cd00063
      Location:545 → 638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:338 → 435
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:442 → 528
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    7. XM_036159961.1 → XP_036015854.1  roundabout homolog 2 isoform X9

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (6) summary
      cd00063
      Location:545 → 638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:338 → 435
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:442 → 528
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    8. XM_036159965.1 → XP_036015858.1  roundabout homolog 2 isoform X22

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (6) summary
      cd00063
      Location:545 → 638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:338 → 435
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:442 → 528
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    9. XM_036159964.1 → XP_036015857.1  roundabout homolog 2 isoform X21

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (6) summary
      cd00063
      Location:545 → 638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:338 → 435
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:442 → 528
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    10. XM_006523042.5 → XP_006523105.1  roundabout homolog 2 isoform X11

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:351 → 440
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:447 → 528
      IG_like; Immunoglobulin like
      cd00063
      Location:545 → 638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    11. XM_006523037.5 → XP_006523100.1  roundabout homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:351 → 440
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00409
      Location:447 → 528
      IG; Immunoglobulin
      cd00063
      Location:545 → 638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    12. XM_017317016.3 → XP_017172505.1  roundabout homolog 2 isoform X23

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (5) summary
      cd05726
      Location:355 → 444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451 → 532
      IG_like; Immunoglobulin like
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    13. XM_006523046.5 → XP_006523109.1  roundabout homolog 2 isoform X15

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:355 → 444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451 → 532
      IG_like; Immunoglobulin like
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    14. XM_036159963.1 → XP_036015856.1  roundabout homolog 2 isoform X18

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (6) summary
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342 → 439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446 → 532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    15. XM_011246131.4 → XP_011244433.1  roundabout homolog 2 isoform X17

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (5) summary
      cd05726
      Location:355 → 444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00409
      Location:451 → 532
      IG; Immunoglobulin
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    16. XM_006523040.5 → XP_006523103.1  roundabout homolog 2 isoform X8

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:355 → 444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00409
      Location:451 → 532
      IG; Immunoglobulin
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    17. XM_006523048.5 → XP_006523111.1  roundabout homolog 2 isoform X20

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (5) summary
      cd05726
      Location:355 → 444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451 → 532
      IG_like; Immunoglobulin like
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    18. XM_017317015.3 → XP_017172504.1  roundabout homolog 2 isoform X19

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (5) summary
      cd05726
      Location:355 → 444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451 → 532
      IG_like; Immunoglobulin like
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    19. XM_006523041.5 → XP_006523104.1  roundabout homolog 2 isoform X10

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:355 → 444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451 → 532
      IG_like; Immunoglobulin like
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    20. XM_030249141.2 → XP_030105001.1  roundabout homolog 2 isoform X14

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (5) summary
      cd05726
      Location:355 → 444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00409
      Location:451 → 532
      IG; Immunoglobulin
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    21. XM_006523045.5 → XP_006523108.1  roundabout homolog 2 isoform X13

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (5) summary
      cd05726
      Location:355 → 444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00409
      Location:451 → 532
      IG; Immunoglobulin
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    22. XM_006523036.5 → XP_006523099.1  roundabout homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:355 → 444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00409
      Location:451 → 532
      IG; Immunoglobulin
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    23. XM_006523035.5 → XP_006523098.1  roundabout homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:355 → 444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00409
      Location:451 → 532
      IG; Immunoglobulin
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    24. XM_036159960.1 → XP_036015853.1  roundabout homolog 2 isoform X7

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (6) summary
      cd00063
      Location:522 → 615
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:136 → 139
      Ig; Ig strand A [structural motif]
      cd05726
      Location:315 → 412
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:31 → 129
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:419 → 505
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:136 → 221
      Ig; Immunoglobulin domain

    25. XM_006523043.5 → XP_006523106.1  roundabout homolog 2 isoform X12

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:332 → 421
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:30 → 129
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:428 → 509
      IG_like; Immunoglobulin like
      cd00063
      Location:526 → 619
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:137 → 221
      Ig; Immunoglobulin domain

    26. XM_006523039.5 → XP_006523102.1  roundabout homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:332 → 421
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:30 → 129
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:428 → 509
      IG_like; Immunoglobulin like
      cd00063
      Location:526 → 619
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:137 → 221
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TPD3.2 GenPept UniProtKB/Swiss-Prot:Q7TPD3

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