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    Rnd1 Rho family GTPase 1 [ Mus musculus (house mouse) ]

    Gene ID: 223881, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnd1provided by MGI
    Official Full Name
    Rho family GTPase 1provided by MGI
    Primary source
    MGI:MGI:2444878
    See related
    Ensembl:ENSMUSG00000054855 AllianceGenome:MGI:2444878
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arhs; A830014L09Rik
    Summary
    Predicted to enable several functions, including GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin filament organization; neuron remodeling; and regulation of actin cytoskeleton organization. Predicted to be located in actin cytoskeleton; adherens junction; and intracellular membrane-bounded organelle. Predicted to be active in cytosol and plasma membrane. Orthologous to human RND1 (Rho family GTPase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 7.9), cerebellum adult (RPKM 7.7) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnd1 in Genome Data Viewer
    Location:
    15 F1; 15 54.65 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98567086..98575342, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98669205..98677461, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, beta 3 subunit Neighboring gene DEAD box helicase 23 Neighboring gene STARR-positive B cell enhancer ABC_E8612 Neighboring gene STARR-positive B cell enhancer ABC_E9922 Neighboring gene predicted gene, 34152 Neighboring gene coiled-coil domain containing 65

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration. Swaminathan B, et al. Sci Rep, 2022 Jan 31. PMID 35102202, Free PMC Article
    2. Rnd1 and Rnd3 targeting to lipid raft is required for p190 RhoGAP activation. Oinuma I, et al. Mol Biol Cell, 2012 Apr. PMID 22357615, Free PMC Article
    3. A novel testis-specific GTPase serves as a link to proteasome biogenesis: functional characterization of RhoS/RSA-14-44 in spermatogenesis. Zhang N, et al. Mol Biol Cell, 2010 Dec. PMID 20980621, Free PMC Article
    4. The semaphorin 3A receptor may directly regulate the activity of small GTPases. Rohm B, et al. FEBS Lett, 2000 Dec 1. PMID 11108845
    5. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration.
      Title: Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho-related GTP-binding protein Rho6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172612.3 → NP_766200.1  rho-related GTP-binding protein Rho6

      See identical proteins and their annotated locations for NP_766200.1

      Status: PROVISIONAL

      Source sequence(s)
      AC156543
      Consensus CDS
      CCDS27801.1
      UniProtKB/Swiss-Prot
      Q3TSQ9, Q80ZR7, Q8BLR7, Q8BYF2
      Related
      ENSMUSP00000003451.5, ENSMUST00000003451.11
      Conserved Domains (2) summary
      smart00174
      Location:16 → 190
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cl21455
      Location:1 → 232
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      98567086..98575342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BLR7.1 GenPept UniProtKB/Swiss-Prot:Q8BLR7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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