Kcnk9 potassium channel, subfamily K, member 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnk9provided by MGI
Official Full Name: potassium channel, subfamily K, member 9provided by MGI
Primary source: MGI:MGI:3521816
See related: Ensembl:ENSMUSG00000036760 AllianceGenome:MGI:3521816
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Task3; A930009L07Rik
Summary: Enables voltage-gated potassium channel activity. Acts upstream of or within potassium ion import across plasma membrane. Predicted to be located in synaptic vesicle. Predicted to be active in plasma membrane. Is expressed in cerebral cortex; early conceptus; and secondary oocyte. Human ortholog(s) of this gene implicated in Birk-Barel syndrome. Orthologous to human KCNK9 (potassium two pore domain channel subfamily K member 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in adrenal adult (RPKM 23.2), cortex adult (RPKM 9.8) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15; 15 D3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (72373722..72422415, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (72501873..72548614, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TASK-3, two-pore potassium channels, contribute to circadian rhythms in the electrical properties of the suprachiasmatic nucleus and play a role in driving stable behavioural photic entrainment.
Title: TASK-3, two-pore potassium channels, contribute to circadian rhythms in the electrical properties of the suprachiasmatic nucleus and play a role in driving stable behavioural photic entrainment.
Biallelic non-productive enhancer-promoter interactions precede imprinted expression of Kcnk9 during mouse neural commitment.
Title: Biallelic non-productive enhancer-promoter interactions precede imprinted expression of Kcnk9 during mouse neural commitment.
TWIK-related acid-sensitive potassium channels TASK-1 and TASK-3 may participate in the process of the coexistence of asthma and OSA.
Title: TWIK-related acid-sensitive potassium channels TASK-1 and TASK-3 may participate in the process of the coexistence of asthma and OSA.
Allelic chromatin structure precedes imprinted expression of Kcnk9 during neurogenesis.
Title: Allelic chromatin structure precedes imprinted expression of Kcnk9 during neurogenesis.
Deficiency of the Two-Pore Potassium Channel KCNK9 Impairs Intestinal Epithelial Cell Survival and Aggravates Dextran Sodium Sulfate-Induced Colitis.
Title: Deficiency of the Two-Pore Potassium Channel KCNK9 Impairs Intestinal Epithelial Cell Survival and Aggravates Dextran Sodium Sulfate-Induced Colitis.
Expression of p11 and heteromeric TASK channels in mouse adrenal cortical cells and H295R cells.
Title: Expression of p11 and heteromeric TASK channels in mouse adrenal cortical cells and H295R cells.
A 5' UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation.
Title: A 5' UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation.
Selective activation of TWIK-related acid-sensitive K(+) 3 subunit-containing channels is analgesic in rodent models.
Title: Selective activation of TWIK-related acid-sensitive K(+) 3 subunit-containing channels is analgesic in rodent models.
TASK-1 and TASK-3 strongly affect the development of pressure overload cardiomyopathies in genetic models of TASK-1 and TASK-3 loss of function.
Title: TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction.
Mutations in the actively expressed, maternal allele of the imprinted KCNK9 gene cause Birk-Barel intellectual disability syndrome (BBIDS). Using a BBIDS mouse model, we identify here a partial rescue of the BBIDS-like behavioral and neuronal phenotypes mediated via residual expression from the paternal Kcnk9 (Kcnk9(pat)) allele.
Title: Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (6) 1 citation

General gene information

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Markers

Kcnk9 (e-PCR), detects polymorphism
- UniSTS:547599

Kcnk9 (e-PCR), detects polymorphism
- UniSTS:547600

D15Mit93 (e-PCR), detects polymorphism
- UniSTS:127717

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables outward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables outward rectifier potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables outward rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to acidic pH	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of aldosterone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within potassium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of action potential firing rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of resting membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium channel subfamily K member 9

Names: TWIK-related acid-sensitive K(+) channel 3; acid-sensitive potassium channel protein TASK-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033876.2 → NP_001029048.1 potassium channel subfamily K member 9 precursor

See identical proteins and their annotated locations for NP_001029048.1

Status: VALIDATED

Source sequence(s)

AC118008, AC161195

Consensus CDS

CCDS27515.1

UniProtKB/Swiss-Prot

B2RT82, Q3LS21

Related

ENSMUSP00000038729.7, ENSMUST00000044624.8

Conserved Domains (1) summary

pfam07885
Location:77 → 132

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

72373722..72422415 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520768.5 → XP_006520831.1 potassium channel subfamily K member 9 isoform X1

Conserved Domains (1) summary

pfam07885
Location:279 → 334

Ion_trans_2; Ion channel
XM_036159328.1 → XP_036015221.1 potassium channel subfamily K member 9 isoform X1

Conserved Domains (1) summary

pfam07885
Location:279 → 334

Ion_trans_2; Ion channel