Dmgdh dimethylglycine dehydrogenase precursor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dmgdhprovided by MGI
Official Full Name: dimethylglycine dehydrogenase precursorprovided by MGI
Primary source: MGI:MGI:1921379
See related: Ensembl:ENSMUSG00000042102 AllianceGenome:MGI:1921379
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1200014D15Rik
Summary: This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. [provided by RefSeq, Jul 2013]
Expression: Biased expression in liver adult (RPKM 68.1), liver E18 (RPKM 28.7) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C3; 13 47.88 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (93810944..93889331)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (93674436..93752823)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ARC may protect cardiomyocytes from hypoxic cell death by regulating its downstream, Drbp1 and pMe(2)GlyDH
Title: Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

General gene information

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Markers

AI787269 (e-PCR)
- UniSTS:180577

AW495222 (e-PCR)
- UniSTS:180579

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dimethylglycine dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dimethylglycine dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables dimethylglycine dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables flavin adenine dinucleotide binding	ISO Inferred from Sequence Orthology more info
enables folic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amino-acid betaine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in choline catabolic process	IEA Inferred from Electronic Annotation more info
involved_in choline catabolic process	ISO Inferred from Sequence Orthology more info
involved_in tetrahydrofolate interconversion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dimethylglycine dehydrogenase, mitochondrial

Names: ME2GLYDH

NP_083048.1

EC 1.5.8.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028772.3 → NP_083048.1 dimethylglycine dehydrogenase, mitochondrial precursor

See identical proteins and their annotated locations for NP_083048.1

Status: VALIDATED

Source sequence(s)

AC131739, CT030023

Consensus CDS

CCDS26690.1

UniProtKB/Swiss-Prot

B1B1D0, Q8R1S7, Q9DBT9

UniProtKB/TrEMBL

Q5EBH4

Related

ENSMUSP00000039663.7, ENSMUST00000048001.8

Conserved Domains (6) summary

COG0404
Location:481 → 850

GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]

COG0665
Location:40 → 428

DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

pfam01571
Location:475 → 738

GCV_T; Aminomethyltransferase folate-binding domain

pfam08669
Location:746 → 838

GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain

pfam16350
Location:410 → 465

FAO_M; FAD dependent oxidoreductase central domain

cl21454
Location:38 → 83

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins