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    Ccdc181 coiled-coil domain containing 181 [ Mus musculus (house mouse) ]

    Gene ID: 74895, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccdc181provided by MGI
    Official Full Name
    coiled-coil domain containing 181provided by MGI
    Primary source
    MGI:MGI:1922145
    See related
    Ensembl:ENSMUSG00000026578 AllianceGenome:MGI:1922145
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930455F23Rik
    Summary
    Enables microtubule binding activity. Located in manchette and sperm flagellum. Is expressed in 3rd ventricle; 4th ventricle; and choroid invagination. Orthologous to human CCDC181 (coiled-coil domain containing 181). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 47.2), frontal lobe adult (RPKM 5.5) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc181 in Genome Data Viewer
    Location:
    1 H2.2; 1 71.59 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (164103126..164115416)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (164275598..164287847)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene coagulation factor V Neighboring gene microRNA 12178 Neighboring gene STARR-seq mESC enhancer starr_02865 Neighboring gene STARR-seq mESC enhancer starr_02866 Neighboring gene solute carrier family 19 (thiamine transporter), member 2 Neighboring gene STARR-seq mESC enhancer starr_02867 Neighboring gene STARR-positive B cell enhancer ABC_E797 Neighboring gene basic leucine zipper nuclear factor 1 Neighboring gene NME/NM23 family member 7 Neighboring gene STARR-positive B cell enhancer ABC_E5840 Neighboring gene STARR-seq mESC enhancer starr_02870 Neighboring gene predicted gene, 39690

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CCDC181 is required for sperm flagellum biogenesis and male fertility in mice. Zhang XJ, et al. Zool Res, 2024 Sep 18. PMID 39245650, Free PMC Article
    2. Ccdc181 is a microtubule-binding protein that interacts with Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia. Schwarz T, et al. Eur J Cell Biol, 2017 May. PMID 28283191, Free PMC Article
    3. Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase. Strong ER, et al. Genes (Basel), 2010 Dec 2. PMID 21779533, Free PMC Article
    4. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CCDC181 is required for sperm flagellum biogenesis and male fertility in mice.
      Title: CCDC181 is required for sperm flagellum biogenesis and male fertility in mice.
    2. Ccdc181 is a binding partner of Hook1. Ccdc181 localizes to the sperm flagella and to the basal half of motile cilia.
      Title: Ccdc181 is a microtubule-binding protein that interacts with Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia.
    3. 4930455F23Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
      Title: Tissue expression patterns identify mouse cilia genes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in manchette IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 181

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029115.3 → NP_083391.2  coiled-coil domain-containing protein 181

      See identical proteins and their annotated locations for NP_083391.2

      Status: VALIDATED

      Source sequence(s)
      BC048086, BC060044
      Consensus CDS
      CCDS15434.1
      UniProtKB/Swiss-Prot
      Q3UF07, Q80ZU5, Q8C631, Q9CUL9
      Related
      ENSMUSP00000027867.7, ENSMUST00000027867.7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      164103126..164115416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154044.1 → XP_036009937.1  coiled-coil domain-containing protein 181 isoform X1

      Conserved Domains (1) summary
      pfam17380
      Location:298 → 455
      DUF5401; Family of unknown function (DUF5401)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZU5.1 GenPept UniProtKB/Swiss-Prot:Q80ZU5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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