Hamp2 hepcidin antimicrobial peptide 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hamp2provided by MGI
Official Full Name: hepcidin antimicrobial peptide 2provided by MGI
Primary source: MGI:MGI:2153530
See related: Ensembl:ENSMUSG00000056978 AllianceGenome:MGI:2153530
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HEPC2; 1810073K19Rik
Summary: This gene encodes a peptide hormone that functions in the regulation of systemic iron metabolism. The encoded preproprotein is synthesized in the hepatocytes where it undergoes proteolytic processing to generate disulfide-linked mature peptides that are secreted into the bloodstream. Transgenic mice overexpressing the encoded protein develop normally with hematologic parameters similar to the non-transgenic mice. This gene is located adjacent to a related hepcidin gene on chromosome 7. [provided by RefSeq, Aug 2016]
Expression: Restricted expression toward liver adult (RPKM 1735.1) See more
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Genomic context

Location:: 7 B1; 7 19.27 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (30621797..30623606, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30922372..30924181, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepcidin role in the iron homeostasis.
Title: Genetic background influences hepcidin response to iron imbalance in a mouse model of hemolytic anemia (Congenital erythropoietic porphyria).
radiation exposure directly or indirectly induces urinary excretion of hepcidin-2 at least in part by the upregulation of Hamp2 mRNA in the liver.
Title: Hepcidin-2 in mouse urine as a candidate radiation-responsive molecule.
Hep-1 and Hep-2 peptide responses in experimental mouse agree with the known biology of hepcidin mRNA regulators.
Title: Mass spectrometry analysis of hepcidin peptides in experimental mouse models.
regulatory variation in hepcidin expression may be just as important as structural variation or mutations within its coding sequence.
Title: Regulatory variation in hepcidin expression as a heritable quantitative trait.
alcohol loading down-regulates hepatic hepcidin expression and leads to the increase of iron absorption from the intestine
Title: Hepcidin is down-regulated in alcohol loading.
Both Hepc 1 and Hepc 2 expression responds coordinately to dietary iron. This work provides additional evidence of the key role of Hepc in the regulation of iron homeostasis.
Title: Dietary iron regulates hepatic hepcidin 1 and 2 mRNAs in mice.
Hepatic Hamp2 expression displays considerable strain- and sex-dependent variation in mice.
Title: Different expression pattern of hepcidin genes in the liver and pancreas of C57BL/6N and DBA/2N mice.
Comparative analysis of sequence, genomic structure and expression of the hepcidin 1 and 2 genes.
Title: Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co-inducibility during iron overload.
Specific hepatic Hepc1 and Hepc2 mRNA and iron levels were quantified and results suggest that sex and genetic background, which are regulators of hepcidin expression, could play a role in the phenotypic expression of genetic hemochromatosis
Title: Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice.
Hepc2 transgenic mRNA level was found to be very high for all lines compared with the level of hepc1 transgene mRNA necessary to produce severe anemia
Title: Functional differences between hepcidin 1 and 2 in transgenic mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables iron ion transmembrane transporter inhibitor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to fungus	IEA Inferred from Electronic Annotation more info
involved_in defense response to fungus	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intestinal absorption	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of iron export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of iron ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in response to iron ion	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical cortex	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hepcidin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183257.4 → NP_899080.2 hepcidin-2 preproprotein

Status: REVIEWED

Source sequence(s)

AK008993, D17962

Consensus CDS

CCDS39894.2

UniProtKB/Swiss-Prot

Q80T19, Q8BFW2

UniProtKB/TrEMBL

Q5M9M1

Related

ENSMUSP00000151677.2, ENSMUST00000217812.2

Conserved Domains (1) summary

pfam06446
Location:32 → 81

Hepcidin; Hepcidin