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    RRAGB Ras related GTP binding B [ Homo sapiens (human) ]

    Gene ID: 10325, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RRAGBprovided by HGNC
    Official Full Name
    Ras related GTP binding Bprovided by HGNC
    Primary source
    HGNC:HGNC:19901
    See related
    Ensembl:ENSG00000083750 MIM:300725; AllianceGenome:HGNC:19901
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAGB; bA465E19.1
    Summary
    Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 5.3), thyroid (RPKM 4.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RRAGB in Genome Data Viewer
    Location:
    Xp11.21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (55717749..55758774)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (55010926..55051952)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (55744182..55785207)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene X antigen family member 3-like Neighboring gene ReSE screen-validated silencer GRCh37_chrX:55700255-55700456 Neighboring gene XAGE-4 protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29684 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:55945424-55946623 Neighboring gene KLF transcription factor 8 Neighboring gene GOT2 pseudogene 6 Neighboring gene uncharacterized LOC124905192

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop. Li X, et al. Mol Cancer, 2022 Jun 23. PMID 35739524, Free PMC Article
    2. Elevated Ras related GTP binding B (RRAGB) expression predicts poor overall survival and constructs a prognostic nomogram for colon adenocarcinoma. Xiao J, et al. Bioengineered, 2021 Dec. PMID 34320917, Free PMC Article
    3. Glutaminolysis activates Rag-mTORC1 signaling. Durán RV, et al. Mol Cell, 2012 Aug 10. PMID 22749528
    4. Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression. Shi Y, et al. Biochem Biophys Res Commun, 2021 Oct 22. PMID 34482023
    5. Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1). Shibutani S, et al. J Biol Chem, 2017 Nov 3. PMID 28808055, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop.
      Title: circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop.
    2. Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression.
      Title: Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression.
    3. Elevated Ras related GTP binding B (RRAGB) expression predicts poor overall survival and constructs a prognostic nomogram for colon adenocarcinoma.
      Title: Elevated Ras related GTP binding B (RRAGB) expression predicts poor overall survival and constructs a prognostic nomogram for colon adenocarcinoma.
    4. Data suggest DNM2/RRAGB- (or DNM2/RRAGC-)dependent endocytosis of extracellular amino acids (AAs) plays critical role in mTORC1 transport/activation; recruitment of mTORC1 from cytoplasm to lysosome is suppressed by DNM2 inhibition; AA deprivation appears to be main cause of mTORC1 inactivation via DNM2 inhibition. (RHEB = Ras homolog enriched in brain; DNM2 = dynamin II; RRAG = Ras-related GTP binding protein)
      Title: Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1).
    5. Inhibition of glutaminolysis prevents GTP loading of RagB and lysosomal translocation and subsequent activation of mTORC1.
      Title: Glutaminolysis activates Rag-mTORC1 signaling.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of smoking behaviours among Bangladeshi adults.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of Ras-related GTP binding B (RRAGB) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables guanyl ribonucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables membrane scission GTPase motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to amino acid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to leucine starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of TOR signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Gtr1-Gtr2 GTPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in lysosomal membrane HDA PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-related GTP-binding protein B
    Names
    GTP-binding protein ragB
    rag B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001354011.2 → NP_001340940.1  ras-related GTP-binding protein B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL139277, AL159987
      Conserved Domains (1) summary
      cd11384
      Location:4 → 315
      RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

    2. NM_001354013.2 → NP_001340942.1  ras-related GTP-binding protein B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL139277, AL159987
      Conserved Domains (1) summary
      cd11384
      Location:4 → 287
      RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

    3. NM_006064.5 → NP_006055.3  ras-related GTP-binding protein B short isoform

      See identical proteins and their annotated locations for NP_006055.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, also known as RAGBs) lacks an alternate in-frame exon in the coding region, compared to variant 1, resulting in a shorter isoform (2).
      Source sequence(s)
      BC034726, DB252202
      Consensus CDS
      CCDS14371.1
      UniProtKB/Swiss-Prot
      Q5VZM2
      Related
      ENSP00000364077.4, ENST00000374941.9
      Conserved Domains (1) summary
      cd11384
      Location:42 → 325
      RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

    4. NM_016656.4 → NP_057740.2  ras-related GTP-binding protein B long isoform

      See identical proteins and their annotated locations for NP_057740.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, also known as RAGBl) encodes the longest isoform (1).
      Source sequence(s)
      BC034726, DB252202, X90530
      Consensus CDS
      CCDS14372.1
      UniProtKB/Swiss-Prot
      A8K042, Q15348, Q5VZM2, Q8N3T0
      Related
      ENSP00000262850.7, ENST00000262850.7
      Conserved Domains (1) summary
      cd11384
      Location:42 → 353
      RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

    RNA

    1. NR_148683.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL139277, AL159987

    2. NR_148684.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL139277, AL159987

    3. NR_148685.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL139277, AL159987

    4. NR_148686.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL139277, AL159987

    5. NR_148687.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL139277, AL159987

    6. NR_148688.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL139277, AL159987

    7. NR_148689.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL139277, AL159987

    8. NR_148690.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL139277, AL159987

    9. NR_148691.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL139277, AL159987

    10. NR_148692.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL139277, AL159987

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      55717749..55758774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029218.3 → XP_016884707.1  ras-related GTP-binding protein B isoform X1

    2. XM_047441764.1 → XP_047297720.1  ras-related GTP-binding protein B isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      55010926..55051952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326364.1 → XP_054182339.1  ras-related GTP-binding protein B isoform X1

    RNA

    1. XR_008485448.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VZM2.1 GenPept UniProtKB/Swiss-Prot:Q5VZM2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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