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    GTF3C1 general transcription factor IIIC subunit 1 [ Homo sapiens (human) ]

    Gene ID: 2975, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GTF3C1provided by HGNC
    Official Full Name
    general transcription factor IIIC subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:4664
    See related
    Ensembl:ENSG00000077235 MIM:603246; AllianceGenome:HGNC:4664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TFIIIC; TFIIIC220; TFIIICalpha
    Summary
    Enables RNA polymerase III general transcription initiation factor activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and transcription initiation at RNA polymerase III promoter. Located in nucleolus and nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 19.5), prostate (RPKM 18.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GTF3C1 in Genome Data Viewer
    Location:
    16p12.1
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (27460613..27549913, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (27739371..27828673, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (27471934..27561234, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene interleukin 21 receptor Neighboring gene uncharacterized LOC124903668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10627 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:27460829-27461706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10632 Neighboring gene IL21R antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:27482643-27483144 Neighboring gene MPRA-validated peak2546 silencer Neighboring gene Sharpr-MPRA regulatory regions 5680 and 15498 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10634 Neighboring gene katanin interacting protein Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:27644974-27645660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:27648141-27648641 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:27652441-27653082 Neighboring gene uncharacterized LOC107984874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:27711973-27712473 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:27713579-27714080 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:27714081-27714580 Neighboring gene uncharacterized LOC100128079

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of two forms of human transcription factor IIIC. Kovelman R, et al. J Biol Chem, 1992 Dec 5. PMID 1447193
    2. TFIIIC as a Potential Epigenetic Modulator of Histone Acetylation in Human Stem Cells. Vezzoli M, et al. Int J Mol Sci, 2023 Feb 11. PMID 36835038, Free PMC Article
    3. Human transcription factor IIIC box B binding subunit. L'Etoile ND, et al. Proc Natl Acad Sci U S A, 1994 Mar 1. PMID 8127861, Free PMC Article
    4. The Largest Subunit of Human TFIIIC Complex, TFIIIC220, a Lysine Acetyltransferase Targets Histone H3K18. Basu M, et al. J Biochem, 2024 Feb 25. PMID 37963603
    5. Binding of TFIIIC to sine elements controls the relocation of activity-dependent neuronal genes to transcription factories. Crepaldi L, et al. PLoS Genet, 2013. PMID 23966877, Free PMC Article

    See all (157) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Largest Subunit of Human TFIIIC Complex, TFIIIC220, a Lysine Acetyltransferase Targets Histone H3K18.
      Title: The Largest Subunit of Human TFIIIC Complex, TFIIIC220, a Lysine Acetyltransferase Targets Histone H3K18.
    2. The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC and Architectural Proteins in Human and Mouse.
      Title: The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC and Architectural Proteins in Human and Mouse.
    3. TFIIIC as a Potential Epigenetic Modulator of Histone Acetylation in Human Stem Cells.
      Title: TFIIIC as a Potential Epigenetic Modulator of Histone Acetylation in Human Stem Cells.
    4. These findings reveal a novel and essential regulatory function of both SINEs and TFIIIC in mediating gene relocation and transcription
      Title: Binding of TFIIIC to sine elements controls the relocation of activity-dependent neuronal genes to transcription factories.
    5. Maf1, a repressor that binds and inhibits pol III, is phosphorylated in a mTOR-dependent manner both in vitro and in vivo at serine 75, a site that contributes to its function as a transcriptional inhibitor.
      Title: mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1.
    6. Results identify TFIIIC as a recruitment factor for p300 and thus may have important implications for the emerging concept that tRNA genes or TFIIIC binding sites act as chromatin barriers to prohibit spreading of silenced heterochromatin domains.
      Title: Different functional modes of p300 in activation of RNA polymerase III transcription from chromatin templates.
    7. TFIIIC is composed of six subunits, five of which are conserved in humans. We report the identification, molecular cloning, and characterization of the sixth subunit of human TFIIIC, TFIIIC35
      Title: Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC.
    8. The partial purification of pol III transcription factors from PE and EC cells revealed that TFIIIC2 activity could be purified from both cell types, whereas TFIIIC1 activity was dramatically reduced in extracts from PE cells.
      Title: The activity of transcription factor IIIC1 is impaired during differentiation of F9 cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686A111

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to DNA binding IC
    Inferred by Curator
    more info
    		 PubMed 
    enables RNA polymerase III general transcription initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 5S class rRNA transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 5S class rRNA transcription by RNA polymerase III IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in rRNA transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in tRNA transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in tRNA transcription by RNA polymerase III IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase III promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIIC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIIC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    general transcription factor 3C polypeptide 1
    Names
    TF3C-alpha
    TFIIIC 220 kDa subunit
    TFIIIC box B-binding subunit
    general transcription factor IIIC, polypeptide 1 (alpha subunit)
    general transcription factor IIIC, polypeptide 1, alpha 220kDa
    transcription factor IIIC 220 kDa subunit
    transcription factor IIIC subunit alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286242.2 → NP_001273171.1  general transcription factor 3C polypeptide 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC002303, AC025275, BC044857, BC137229
      Consensus CDS
      CCDS66988.1
      UniProtKB/TrEMBL
      Q6AHZ7
      Related
      ENSP00000455417.1, ENST00000561623.5
      Conserved Domains (1) summary
      pfam04182
      Location:174 → 250
      B-block_TFIIIC; B-block binding subunit of TFIIIC

    2. NM_001520.4 → NP_001511.2  general transcription factor 3C polypeptide 1 isoform 1

      See identical proteins and their annotated locations for NP_001511.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC044857, BC137229, BP283960, CA414192
      Consensus CDS
      CCDS32414.1
      UniProtKB/Swiss-Prot
      B2RP21, Q12789, Q12838, Q6DKN9, Q9Y4W9
      UniProtKB/TrEMBL
      Q6AHZ7
      Related
      ENSP00000348510.4, ENST00000356183.9
      Conserved Domains (2) summary
      pfam04182
      Location:174 → 250
      B-block_TFIIIC; B-block binding subunit of TFIIIC
      cl22974
      Location:1881 → 1975
      HpaP; Type III secretion protein (HpaP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      27460613..27549913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434036.1 → XP_047289992.1  general transcription factor 3C polypeptide 1 isoform X2

      UniProtKB/TrEMBL
      Q6AHZ7

    2. XM_017023188.3 → XP_016878677.1  general transcription factor 3C polypeptide 1 isoform X1

      UniProtKB/TrEMBL
      Q6AHZ7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      27739371..27828673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380183.1 → XP_054236158.1  general transcription factor 3C polypeptide 1 isoform X2

      UniProtKB/TrEMBL
      Q6AHZ7

    2. XM_054380182.1 → XP_054236157.1  general transcription factor 3C polypeptide 1 isoform X1

      UniProtKB/TrEMBL
      Q6AHZ7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12789.4 GenPept UniProtKB/Swiss-Prot:Q12789

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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