U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    WNK3 WNK lysine deficient protein kinase 3 [ Homo sapiens (human) ]

    Gene ID: 65267, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    WNK3provided by HGNC
    Official Full Name
    WNK lysine deficient protein kinase 3provided by HGNC
    Primary source
    HGNC:HGNC:14543
    See related
    Ensembl:ENSG00000196632 MIM:300358; AllianceGenome:HGNC:14543
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRS; MRXS2; PRKWNK3
    Summary
    This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
    Expression
    Biased expression in testis (RPKM 7.2), brain (RPKM 1.1) and 5 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See WNK3 in Genome Data Viewer
    Location:
    Xp11.22
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (54192823..54358900, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (53482708..53648791, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (54219256..54384479, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5322 Neighboring gene MPRA-validated peak7381 silencer Neighboring gene PHD finger protein 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29669 Neighboring gene Sharpr-MPRA regulatory region 9958 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:54091510-54091662 Neighboring gene family with sequence similarity 120 member C Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:54154862-54155382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20861 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20863 Neighboring gene ribosomal protein L37 pseudogene 24 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:54242133-54242784 Neighboring gene ribosomal protein L7a pseudogene 71 Neighboring gene MPRA-validated peak7382 silencer Neighboring gene RNA, U6 small nuclear 434, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:54415213-54415877 Neighboring gene MPRA-validated peak7383 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29670 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:54505803-54506356 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20864 Neighboring gene TSR2 ribosome maturation factor Neighboring gene FYVE, RhoGEF and PH domain containing 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:54556053-54556573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29673 Neighboring gene G protein nucleolar 3 like Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:54665616-54666141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29675

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Gene localization in a family with X-linked syndromal mental retardation (Prieto syndrome). Watty A, et al. Am J Med Genet, 1991 Feb-Mar. PMID 1673297
    2. With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume. Haas BR, et al. Am J Physiol Cell Physiol, 2011 Nov. PMID 21813709, Free PMC Article
    3. Influence of WNK3 on intracellular chloride concentration and volume regulation in HEK293 cells. Cruz-Rangel S, et al. Pflugers Arch, 2012 Sep. PMID 22864523
    4. WNK3 Kinase Enhances the Sodium Chloride Cotransporter Expression via an ERK 1/2 Signaling Pathway. Wang D, et al. Nephron, 2016. PMID 27467688
    5. Emerging roles for WNK kinases in cancer. Moniz S, et al. Cell Mol Life Sci, 2010 Apr. PMID 20094755, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WNK3 inhibition elicits antitumor immunity by suppressing PD-L1 expression on tumor cells and activating T-cell function.
      Title: WNK3 inhibition elicits antitumor immunity by suppressing PD-L1 expression on tumor cells and activating T-cell function.
    2. WNKs are potassium-sensitive kinases.
      Title: WNKs are potassium-sensitive kinases.
    3. Advances in the study of the role and molecular mechanism of withnolysine kinase 3 in nervous system diseases (Review).
      Title: Advances in the study of the role and molecular mechanism of with‑no‑lysine kinase 3 in nervous system diseases (Review).
    4. A Phosphorylated Intermediate in the Activation of WNK Kinases.
      Title: A Phosphorylated Intermediate in the Activation of WNK Kinases.
    5. This study demonstrated that the WNK3 up regulation in hippocampal specimens from epileptic patients with hippocampal sclerosis.
      Title: Increased expression of WNK3 in dispersed granule cells in hippocampal sclerosis of mesial temporal lobe epilepsy patients.
    6. Data show that WNK lysine deficient protein kinase 3 protein (WNK3) interacts with NCC and increases the Na-Cl cotransporter (NCC) expression on the cell membrane and in cytoplasm together.
      Title: WNK3 interacts with NCC.
    7. WNK3 enhances NCC protein expression by increasing NCC synthesis via an ERK 1/2-dependent signaling pathway
      Title: WNK3 Kinase Enhances the Sodium Chloride Cotransporter Expression via an ERK 1/2 Signaling Pathway.
    8. WNK3 knockout mice exhibited significantly decreased infarct volume in a transgenic model of stroke and brain damage.
      Title: Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke.
    9. There may be a novel role for WNK3 on the renal Na+-Cl-cotransporter (NCC) expression at the plasma membrane, an effect apparently independent of the SPAK kinase and the aldosterone-SGK1 pathway.
      Title: WNK3 abrogates the NEDD4-2-mediated inhibition of the renal Na+-Cl- cotransporter.
    10. LINGO-1 potentiates neuronal apoptosis, likely by inhibiting WNK3 kinase activity.
      Title: LINGO-1 receptor promotes neuronal apoptosis by inhibiting WNK3 kinase activity.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Prieto syndrome
    MedGen: C1839730 OMIM: 309610 GeneReviews: Not available
    		not available

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ30437, FLJ42662, KIAA1566

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular condensate scaffold activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell volume homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of cell volume homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell volume homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cellular hyperosmotic response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within maintenance of blood-brain barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in membraneless organelle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of pancreatic juice secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of osmosensory signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of peptidyl-threonine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of sodium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of sodium ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of sodium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of calcium ion import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of regulation of monoatomic cation transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of regulation of monoatomic cation transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in bicellular tight junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    serine/threonine-protein kinase WNK3
    Names
    Prieto X-linked mental retardation syndrome
    protein kinase with no lysine 3
    NP_001002838.1
    NP_001382095.1
    NP_065973.2
    XP_011529104.1
    XP_016885230.1
    XP_016885231.1
    XP_016885232.1
    XP_016885233.1
    XP_016885234.1
    XP_047298332.1
    XP_047298333.1
    XP_047298334.1
    XP_047298335.1
    XP_047298336.1
    XP_047298337.1
    XP_047298338.1
    XP_047298339.1
    XP_047298340.1
    XP_047298341.1
    XP_047298342.1
    XP_047298343.1
    XP_047298344.1
    XP_054183574.1
    XP_054183575.1
    XP_054183576.1
    XP_054183577.1
    XP_054183578.1
    XP_054183579.1
    XP_054183580.1
    XP_054183581.1
    XP_054183582.1
    XP_054183583.1
    XP_054183584.1
    XP_054183585.1
    XP_054183586.1
    XP_054183587.1
    XP_054183588.1
    XP_054183589.1
    XP_054183590.1
    XP_054183591.1
    XP_054183592.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021259.2 RefSeqGene

      Range
      5001..170183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001002838.4 → NP_001002838.1  serine/threonine-protein kinase WNK3 isoform 2

      See identical proteins and their annotated locations for NP_001002838.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AJ409088, AL591766, AY352048, R44257, Z84469
      Consensus CDS
      CCDS35302.1
      UniProtKB/Swiss-Prot
      Q9BYP7
      Related
      ENSP00000364312.3, ENST00000375169.7
      Conserved Domains (2) summary
      cd14031
      Location:136 → 410
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:426 → 489
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    2. NM_001395166.1 → NP_001382095.1  serine/threonine-protein kinase WNK3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL049793, AL591766, Z84469
      Consensus CDS
      CCDS35302.1
      Conserved Domains (2) summary
      cd14031
      Location:136 → 410
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:426 → 489
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    3. NM_020922.5 → NP_065973.2  serine/threonine-protein kinase WNK3 isoform 1

      See identical proteins and their annotated locations for NP_065973.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL591766, AY352048, R44257, Z84469
      Consensus CDS
      CCDS14357.1
      UniProtKB/Swiss-Prot
      B1AKG2, Q5JRC1, Q6JP76, Q8TCX6, Q9BYP7, Q9HCK6
      Related
      ENSP00000346667.2, ENST00000354646.7
      Conserved Domains (3) summary
      smart00220
      Location:152 → 405
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14031
      Location:136 → 410
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:426 → 463
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      54192823..54358900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442382.1 → XP_047298338.1  serine/threonine-protein kinase WNK3 isoform X4

    2. XM_047442379.1 → XP_047298335.1  serine/threonine-protein kinase WNK3 isoform X3

    3. XM_017029744.2 → XP_016885233.1  serine/threonine-protein kinase WNK3 isoform X1

      UniProtKB/Swiss-Prot
      B1AKG2, Q5JRC1, Q6JP76, Q8TCX6, Q9BYP7, Q9HCK6
      Conserved Domains (3) summary
      smart00220
      Location:152 → 405
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14031
      Location:136 → 410
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:426 → 463
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    4. XM_047442383.1 → XP_047298339.1  serine/threonine-protein kinase WNK3 isoform X4

    5. XM_047442381.1 → XP_047298337.1  serine/threonine-protein kinase WNK3 isoform X4

    6. XM_047442378.1 → XP_047298334.1  serine/threonine-protein kinase WNK3 isoform X3

    7. XM_017029743.2 → XP_016885232.1  serine/threonine-protein kinase WNK3 isoform X1

      UniProtKB/Swiss-Prot
      B1AKG2, Q5JRC1, Q6JP76, Q8TCX6, Q9BYP7, Q9HCK6
      Conserved Domains (3) summary
      smart00220
      Location:152 → 405
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14031
      Location:136 → 410
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:426 → 463
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    8. XM_011530802.3 → XP_011529104.1  serine/threonine-protein kinase WNK3 isoform X3

      See identical proteins and their annotated locations for XP_011529104.1

      UniProtKB/Swiss-Prot
      Q9BYP7
      Conserved Domains (3) summary
      smart00220
      Location:152 → 405
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14031
      Location:136 → 410
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:426 → 463
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    9. XM_017029745.2 → XP_016885234.1  serine/threonine-protein kinase WNK3 isoform X2

      UniProtKB/Swiss-Prot
      Q9BYP7

    10. XM_017029741.2 → XP_016885230.1  serine/threonine-protein kinase WNK3 isoform X1

      UniProtKB/Swiss-Prot
      B1AKG2, Q5JRC1, Q6JP76, Q8TCX6, Q9BYP7, Q9HCK6
      Conserved Domains (3) summary
      smart00220
      Location:152 → 405
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14031
      Location:136 → 410
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:426 → 463
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    11. XM_047442380.1 → XP_047298336.1  serine/threonine-protein kinase WNK3 isoform X4

    12. XM_047442376.1 → XP_047298332.1  serine/threonine-protein kinase WNK3 isoform X3

    13. XM_017029742.2 → XP_016885231.1  serine/threonine-protein kinase WNK3 isoform X1

      UniProtKB/Swiss-Prot
      B1AKG2, Q5JRC1, Q6JP76, Q8TCX6, Q9BYP7, Q9HCK6
      Conserved Domains (3) summary
      smart00220
      Location:152 → 405
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14031
      Location:136 → 410
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:426 → 463
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    14. XM_047442377.1 → XP_047298333.1  serine/threonine-protein kinase WNK3 isoform X3

    15. XM_047442388.1 → XP_047298344.1  serine/threonine-protein kinase WNK3 isoform X5

    16. XM_047442387.1 → XP_047298343.1  serine/threonine-protein kinase WNK3 isoform X5

    17. XM_047442384.1 → XP_047298340.1  serine/threonine-protein kinase WNK3 isoform X5

    18. XM_047442385.1 → XP_047298341.1  serine/threonine-protein kinase WNK3 isoform X5

    19. XM_047442386.1 → XP_047298342.1  serine/threonine-protein kinase WNK3 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      53482708..53648791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327611.1 → XP_054183586.1  serine/threonine-protein kinase WNK3 isoform X4

    2. XM_054327608.1 → XP_054183583.1  serine/threonine-protein kinase WNK3 isoform X3

    3. XM_054327602.1 → XP_054183577.1  serine/threonine-protein kinase WNK3 isoform X1

      UniProtKB/Swiss-Prot
      B1AKG2, Q5JRC1, Q6JP76, Q8TCX6, Q9BYP7, Q9HCK6

    4. XM_054327612.1 → XP_054183587.1  serine/threonine-protein kinase WNK3 isoform X4

    5. XM_054327610.1 → XP_054183585.1  serine/threonine-protein kinase WNK3 isoform X4

    6. XM_054327607.1 → XP_054183582.1  serine/threonine-protein kinase WNK3 isoform X3

    7. XM_054327601.1 → XP_054183576.1  serine/threonine-protein kinase WNK3 isoform X1

      UniProtKB/Swiss-Prot
      B1AKG2, Q5JRC1, Q6JP76, Q8TCX6, Q9BYP7, Q9HCK6

    8. XM_054327609.1 → XP_054183584.1  serine/threonine-protein kinase WNK3 isoform X4

    9. XM_054327605.1 → XP_054183580.1  serine/threonine-protein kinase WNK3 isoform X3

    10. XM_054327600.1 → XP_054183575.1  serine/threonine-protein kinase WNK3 isoform X1

      UniProtKB/Swiss-Prot
      B1AKG2, Q5JRC1, Q6JP76, Q8TCX6, Q9BYP7, Q9HCK6

    11. XM_054327604.1 → XP_054183579.1  serine/threonine-protein kinase WNK3 isoform X3

    12. XM_054327603.1 → XP_054183578.1  serine/threonine-protein kinase WNK3 isoform X2

    13. XM_054327599.1 → XP_054183574.1  serine/threonine-protein kinase WNK3 isoform X1

      UniProtKB/Swiss-Prot
      B1AKG2, Q5JRC1, Q6JP76, Q8TCX6, Q9BYP7, Q9HCK6

    14. XM_054327606.1 → XP_054183581.1  serine/threonine-protein kinase WNK3 isoform X3

    15. XM_054327617.1 → XP_054183592.1  serine/threonine-protein kinase WNK3 isoform X5

    16. XM_054327616.1 → XP_054183591.1  serine/threonine-protein kinase WNK3 isoform X5

    17. XM_054327614.1 → XP_054183589.1  serine/threonine-protein kinase WNK3 isoform X5

    18. XM_054327613.1 → XP_054183588.1  serine/threonine-protein kinase WNK3 isoform X5

    19. XM_054327615.1 → XP_054183590.1  serine/threonine-protein kinase WNK3 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BYP7.3 GenPept UniProtKB/Swiss-Prot:Q9BYP7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools