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    ZFP28 ZFP28 zinc finger protein [ Homo sapiens (human) ]

    Gene ID: 140612, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZFP28provided by HGNC
    Official Full Name
    ZFP28 zinc finger proteinprovided by HGNC
    Primary source
    HGNC:HGNC:17801
    See related
    Ensembl:ENSG00000196867 MIM:616798; AllianceGenome:HGNC:17801
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    mkr5
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 2.5), brain (RPKM 2.0) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZFP28 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (56536947..56556808)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (59631381..59651208)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57050317..57068177)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF667 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC124904776 Neighboring gene zinc finger protein 471 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:57037017-57038216 Neighboring gene ZFP28 divergent transcript Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:57058653-57059852 Neighboring gene ZNF470 divergent transcript Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:57065620-57066819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15122 Neighboring gene zinc finger protein 470 Neighboring gene uncharacterized LOC124904777

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Zinc finger protein 28 as a novel melanoma-related molecule. Yajima I, et al. J Dermatol Sci, 2009 Jul. PMID 19329283
    2. Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development. Zhou L, et al. Biochem Biophys Res Commun, 2002 Jul 26. PMID 12127974
    3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Feb 28. PMID 10718198
    4. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924
    5. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these results suggest that murine and human Zfp28/ZFP28 is correlated with the pathogenesis of melanoma.
      Title: Zinc finger protein 28 as a novel melanoma-related molecule.
    2. Characterization of ZFP28 and its role in human development
      Title: Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1431, MGC104540, DKFZp686K03205

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 28 homolog
    Names
    krueppel-like zinc finger factor X6
    zfp-28
    zinc finger factor X6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308440.2 → NP_001295369.1  zinc finger protein 28 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' terminal exon that extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC005498, AF507045, BC028416
      Consensus CDS
      CCDS77363.1
      UniProtKB/TrEMBL
      A8K0L8
      Related
      ENSP00000468603.1, ENST00000591844.5
      Conserved Domains (2) summary
      smart00349
      Location:103 → 163
      KRAB; krueppel associated box
      pfam01352
      Location:103 → 142
      KRAB; KRAB box

    2. NM_020828.2 → NP_065879.1  zinc finger protein 28 homolog isoform 1

      See identical proteins and their annotated locations for NP_065879.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC005498, AF507045
      Consensus CDS
      CCDS12946.1
      UniProtKB/Swiss-Prot
      A0JNV6, K7ES88, Q8NHU8, Q8NHY6, Q9BY30, Q9P2B6
      Related
      ENSP00000301318.3, ENST00000301318.8
      Conserved Domains (6) summary
      smart00349
      Location:103 → 163
      KRAB; krueppel associated box
      COG5048
      Location:417 → 806
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:619 → 639
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:420 → 442
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:103 → 142
      KRAB; KRAB box
      pfam13465
      Location:659 → 684
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      56536947..56556808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526463.4 → XP_011524765.2  zinc finger protein 28 homolog isoform X1

    2. XM_011526462.4 → XP_011524764.1  zinc finger protein 28 homolog isoform X2

      See identical proteins and their annotated locations for XP_011524764.1

      Conserved Domains (6) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:320 → 709
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:522 → 542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:323 → 345
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:562 → 587
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      59631381..59651208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319838.1 → XP_054175813.1  zinc finger protein 28 homolog isoform X1

    2. XM_054319839.1 → XP_054175814.1  zinc finger protein 28 homolog isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NHY6.1 GenPept UniProtKB/Swiss-Prot:Q8NHY6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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