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    PARPBP PARP1 binding protein [ Homo sapiens (human) ]

    Gene ID: 55010, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PARPBPprovided by HGNC
    Official Full Name
    PARP1 binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:26074
    See related
    Ensembl:ENSG00000185480 MIM:613687; AllianceGenome:HGNC:26074
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AROM; PARI; C12orf48
    Summary
    Predicted to enable DNA binding activity. Involved in negative regulation of double-strand break repair via homologous recombination. Located in chromatin and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bone marrow (RPKM 2.3), testis (RPKM 1.7) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PARPBP in Genome Data Viewer
    Location:
    12q23.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (102120183..102197520)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (102081315..102158656)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (102513961..102591298)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene WASH complex subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6878 Neighboring gene nucleoporin 37 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6879 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:102514807-102515364 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:102546739-102547240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6880 Neighboring gene uncharacterized LOC124902998 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_22888 Neighboring gene pro-melanin concentrating hormone Neighboring gene RNA, 7SL, cytoplasmic 793, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PARI overexpression promotes genomic instability and pancreatic tumorigenesis. O'Connor KW, et al. Cancer Res, 2013 Apr 15. PMID 23436799, Free PMC Article
    2. Meta-analysis of the cell cycle related C12orf48. Varisli L. Biocell, 2013 Apr. PMID 24396997
    3. Poly (ADP-ribose) polymerase-1 Binding Protein Facilitates Lung Adenocarcinoma Cell Proliferation and Correlates with Poor Prognosis. Xu D, et al. Ann Clin Lab Sci, 2019 Sep. PMID 31611199
    4. PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells. Nicolae CM, et al. Oncogene, 2019 Jul. PMID 30967629
    5. Overexpression of PARPBP Correlates with Tumor Progression and Poor Prognosis in Hepatocellular Carcinoma. Yu B, et al. Dig Dis Sci, 2019 Oct. PMID 30949905

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP.
      Title: SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP.
    2. PARP1-binding protein was significantly upregulated in Hepatocellular Carcinoma tissues compared with normal liver. High PARPBP expression was associated with elevated serum AFP level, vascular invasion, poor tumor differentiation, and advanced TNM stage.
      Title: Overexpression of PARPBP Correlates with Tumor Progression and Poor Prognosis in Hepatocellular Carcinoma.
    3. PARPBP expression is enhanced in lung adenocarcinoma tissues and is a potential factor in the progression of lung adenocarcinoma.
      Title: Poly (ADP-ribose) polymerase-1 Binding Protein Facilitates Lung Adenocarcinoma Cell Proliferation and Correlates with Poor Prognosis.
    4. show that PARI expression negatively correlates with expression of differentiation markers in clinical myeloid leukemia samples, suggesting that targeting PARI may restore differentiation ability of leukemia cells and antagonize their proliferation
      Title: PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells.
    5. PARI plays potential oncogenic roles and functions as a transcriptional target and effector of FOXM1 in gastric cancer development
      Title: PARI functions as a new transcriptional target of FOXM1 involved in gastric cancer development.
    6. PARI is a latent modulator of stalled fork processing, which is required for stable genome inheritance under both endogenous and exogenous replication stress
      Title: PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice.
    7. PARI inhibits homologous recombination in vivo, and its knockdown suppresses the UV sensitivity of RAD18-depleted cells
      Title: The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis.
    8. PARI overexpression promotes genomic instability and pancreatic tumorigenesis.
      Title: PARI overexpression promotes genomic instability and pancreatic tumorigenesis.
    9. Knockdown of C12orf48 by siRNA in HeLa cells significantly suppressed their growth
      Title: GeneFriends: an online co-expression analysis tool to identify novel gene targets for aging and complex diseases.
    10. PARI suppresses inappropriate recombination events at mammalian replication forks.
      Title: Inhibition of homologous recombination by the PCNA-interacting protein PARI.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of 15 loci influencing height in a Korean population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20641

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    PCNA-interacting partner

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319988.2 → NP_001306917.1  PCNA-interacting partner isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC079907, AC087882
      Consensus CDS
      CCDS81728.1
      UniProtKB/TrEMBL
      B4DZ31
      Related
      ENSP00000440850.1, ENST00000541394.5
      Conserved Domains (1) summary
      TIGR01074
      Location:249 → 393
      rep; ATP-dependent DNA helicase Rep

    2. NM_001319993.2 → NP_001306922.1  PCNA-interacting partner isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon and lacks an exon in the 5' region, and initiates translation at downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and is shorter than isoform 1. Variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AC079907, AC087882
      Consensus CDS
      CCDS81730.1
      Conserved Domains (1) summary
      TIGR01074
      Location:91 → 235
      rep; ATP-dependent DNA helicase Rep

    3. NM_001319994.2 → NP_001306923.1  PCNA-interacting partner isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site and lacks an exon in the 5' region, and initiates translation at downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and is shorter than isoform 1. Variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AC079907, AC087882
      Consensus CDS
      CCDS81730.1
      Related
      ENSP00000376643.2, ENST00000392911.6
      Conserved Domains (1) summary
      TIGR01074
      Location:91 → 235
      rep; ATP-dependent DNA helicase Rep

    4. NM_001319995.3 → NP_001306924.1  PCNA-interacting partner isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate exon and lacks an exon in the 5' region, lacks multiple 3' coding exons, and contains an alternate 3' coding region and 3' UTR, compared to variant 1. It initiates translation at a downstream start codon. The encoded isoform (4) has a shorter N-terminus and a distinct C-terminus, and is shorter than isoform 1.
      Source sequence(s)
      AC087882, AF274940, BC070270, CA415422, DB260405
      UniProtKB/Swiss-Prot
      Q9NWS1
      UniProtKB/TrEMBL
      Q9BZU5
      Conserved Domains (1) summary
      TIGR01074
      Location:91 → 140
      rep; ATP-dependent DNA helicase Rep

    5. NM_001319996.2 → NP_001306925.1  PCNA-interacting partner isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks multiple 3' coding exons and differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (5) has a shorter, distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC079907, AC087882
      Consensus CDS
      CCDS81729.1
      UniProtKB/TrEMBL
      G8JLI2
      Related
      ENSP00000442549.1, ENST00000537257.5

    6. NM_001382721.1 → NP_001369650.1  PCNA-interacting partner isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    7. NM_001382722.1 → NP_001369651.1  PCNA-interacting partner isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    8. NM_001382723.1 → NP_001369652.1  PCNA-interacting partner isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    9. NM_001382724.1 → NP_001369653.1  PCNA-interacting partner isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    10. NM_001382725.1 → NP_001369654.1  PCNA-interacting partner isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    11. NM_001382726.1 → NP_001369655.1  PCNA-interacting partner isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    12. NM_001382728.1 → NP_001369657.1  PCNA-interacting partner isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    13. NM_001382729.1 → NP_001369658.1  PCNA-interacting partner isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    14. NM_001382731.1 → NP_001369660.1  PCNA-interacting partner isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
      UniProtKB/TrEMBL
      J3KQY3
      Related
      ENSP00000411313.2, ENST00000417507.6

    15. NM_001382732.1 → NP_001369661.1  PCNA-interacting partner isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
      UniProtKB/TrEMBL
      A0A0C4DG30
      Related
      ENSP00000393867.2, ENST00000412715.3

    16. NM_001382735.1 → NP_001369664.1  PCNA-interacting partner isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
      Consensus CDS
      CCDS91743.1
      UniProtKB/TrEMBL
      B4DT40
      Related
      ENSP00000444576.1, ENST00000543784.5

    17. NM_001400853.1 → NP_001387782.1  PCNA-interacting partner isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    18. NM_001400854.1 → NP_001387783.1  PCNA-interacting partner isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    19. NM_001400855.1 → NP_001387784.1  PCNA-interacting partner isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    20. NM_001400856.1 → NP_001387785.1  PCNA-interacting partner isoform 20

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    21. NM_001400857.1 → NP_001387786.1  PCNA-interacting partner isoform 21

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    22. NM_001400858.1 → NP_001387787.1  PCNA-interacting partner isoform 22

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    23. NM_001400859.1 → NP_001387788.1  PCNA-interacting partner isoform 23

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    24. NM_001400860.1 → NP_001387789.1  PCNA-interacting partner isoform 23

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    25. NM_001400861.1 → NP_001387790.1  PCNA-interacting partner isoform 23

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    26. NM_001400862.1 → NP_001387791.1  PCNA-interacting partner isoform 24

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    27. NM_001400863.1 → NP_001387792.1  PCNA-interacting partner isoform 25

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    28. NM_001400864.1 → NP_001387793.1  PCNA-interacting partner isoform 26

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    29. NM_001400865.1 → NP_001387794.1  PCNA-interacting partner isoform 27

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    30. NM_001400866.1 → NP_001387795.1  PCNA-interacting partner isoform 28

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    31. NM_001400867.1 → NP_001387796.1  PCNA-interacting partner isoform 29

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    32. NM_001400868.1 → NP_001387797.1  PCNA-interacting partner isoform 30

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    33. NM_001400869.1 → NP_001387798.1  PCNA-interacting partner isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    34. NM_001400870.1 → NP_001387799.1  PCNA-interacting partner isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    35. NM_001400871.1 → NP_001387800.1  PCNA-interacting partner isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    36. NM_001400872.1 → NP_001387801.1  PCNA-interacting partner isoform 32

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    37. NM_001400873.1 → NP_001387802.1  PCNA-interacting partner isoform 33

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    38. NM_001400874.1 → NP_001387803.1  PCNA-interacting partner isoform 34

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    39. NM_001400875.1 → NP_001387804.1  PCNA-interacting partner isoform 35

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    40. NM_001400876.1 → NP_001387805.1  PCNA-interacting partner isoform 36

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    41. NM_001400877.1 → NP_001387806.1  PCNA-interacting partner isoform 37

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    42. NM_001400878.1 → NP_001387807.1  PCNA-interacting partner isoform 38

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    43. NM_001400879.1 → NP_001387808.1  PCNA-interacting partner isoform 39

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    44. NM_001400880.1 → NP_001387809.1  PCNA-interacting partner isoform 40

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    45. NM_001400881.1 → NP_001387810.1  PCNA-interacting partner isoform 41

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    46. NM_001400883.1 → NP_001387812.1  PCNA-interacting partner isoform 42

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    47. NM_001400884.1 → NP_001387813.1  PCNA-interacting partner isoform 43

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    48. NM_001400885.1 → NP_001387814.1  PCNA-interacting partner isoform 44

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    49. NM_001400886.1 → NP_001387815.1  PCNA-interacting partner isoform 45

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    50. NM_001400887.1 → NP_001387816.1  PCNA-interacting partner isoform 46

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
      UniProtKB/TrEMBL
      J3KQY3

    51. NM_001400888.1 → NP_001387817.1  PCNA-interacting partner isoform 46

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
      UniProtKB/TrEMBL
      J3KQY3

    52. NM_001400889.1 → NP_001387818.1  PCNA-interacting partner isoform 46

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
      UniProtKB/TrEMBL
      J3KQY3

    53. NM_001400890.1 → NP_001387819.1  PCNA-interacting partner isoform 47

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    54. NM_001400891.1 → NP_001387820.1  PCNA-interacting partner isoform 48

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    55. NM_001400892.1 → NP_001387821.1  PCNA-interacting partner isoform 49

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
      UniProtKB/TrEMBL
      A0A0C4DG30

    56. NM_001400893.1 → NP_001387822.1  PCNA-interacting partner isoform 49

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
      UniProtKB/TrEMBL
      A0A0C4DG30

    57. NM_001400894.1 → NP_001387823.1  PCNA-interacting partner isoform 49

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
      UniProtKB/TrEMBL
      A0A0C4DG30

    58. NM_001400895.1 → NP_001387824.1  PCNA-interacting partner isoform 49

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
      UniProtKB/TrEMBL
      A0A0C4DG30

    59. NM_001400896.1 → NP_001387825.1  PCNA-interacting partner isoform 50

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    60. NM_001400897.1 → NP_001387826.1  PCNA-interacting partner isoform 51

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    61. NM_001400902.1 → NP_001387831.1  PCNA-interacting partner isoform 52

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    62. NM_001400903.1 → NP_001387832.1  PCNA-interacting partner isoform 53

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    63. NM_001400904.1 → NP_001387833.1  PCNA-interacting partner isoform 54

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    64. NM_001400905.1 → NP_001387834.1  PCNA-interacting partner isoform 54

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    65. NM_001400906.1 → NP_001387835.1  PCNA-interacting partner isoform 55

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    66. NM_001400907.1 → NP_001387836.1  PCNA-interacting partner isoform 61

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    67. NM_001400925.1 → NP_001387854.1  PCNA-interacting partner isoform 56

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    68. NM_001400926.1 → NP_001387855.1  PCNA-interacting partner isoform 57

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    69. NM_001400927.1 → NP_001387856.1  PCNA-interacting partner isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
      Consensus CDS
      CCDS81729.1
      UniProtKB/TrEMBL
      G8JLI2

    70. NM_001400928.1 → NP_001387857.1  PCNA-interacting partner isoform 59

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    71. NM_001400929.1 → NP_001387858.1  PCNA-interacting partner isoform 60

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882

    72. NM_017915.5 → NP_060385.3  PCNA-interacting partner isoform 2

      See identical proteins and their annotated locations for NP_060385.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC079907, AC087882
      Consensus CDS
      CCDS9090.2
      UniProtKB/Swiss-Prot
      B4E0Y0, Q05C00, Q499L8, Q4FZA0, Q4KMW7, Q6NSC6, Q6PJA1, Q86W36, Q9NWS1
      Related
      ENSP00000332915.3, ENST00000327680.7
      Conserved Domains (1) summary
      TIGR01074
      Location:172 → 316
      rep; ATP-dependent DNA helicase Rep

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      102120183..102197520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429048.1 → XP_047285004.1  PCNA-interacting partner isoform X2

    2. XM_047429049.1 → XP_047285005.1  PCNA-interacting partner isoform X5

    3. XM_047429050.1 → XP_047285006.1  PCNA-interacting partner isoform X6

    4. XM_011538514.3 → XP_011536816.1  PCNA-interacting partner isoform X1

      See identical proteins and their annotated locations for XP_011536816.1

      Conserved Domains (1) summary
      TIGR01074
      Location:91 → 235
      rep; ATP-dependent DNA helicase Rep

    5. XM_047429052.1 → XP_047285008.1  PCNA-interacting partner isoform X8

    6. XM_047429051.1 → XP_047285007.1  PCNA-interacting partner isoform X7

    7. XM_047429055.1 → XP_047285011.1  PCNA-interacting partner isoform X11

      UniProtKB/TrEMBL
      A0A0C4DG30

    8. XM_017019541.3 → XP_016875030.1  PCNA-interacting partner isoform X3

    9. XM_047429054.1 → XP_047285010.1  PCNA-interacting partner isoform X10

      UniProtKB/TrEMBL
      A0A0C4DG30

    10. XM_047429053.1 → XP_047285009.1  PCNA-interacting partner isoform X9

      UniProtKB/TrEMBL
      A0A0C4DG30

    11. XM_047429056.1 → XP_047285012.1  PCNA-interacting partner isoform X12

    12. XM_047429057.1 → XP_047285013.1  PCNA-interacting partner isoform X13

    13. XM_011538515.2 → XP_011536817.1  PCNA-interacting partner isoform X4

    RNA

    1. XR_007063095.1 RNA Sequence

    2. XR_007063096.1 RNA Sequence

    3. XR_007063097.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      102081315..102158656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372369.1 → XP_054228344.1  PCNA-interacting partner isoform X2

    2. XM_054372372.1 → XP_054228347.1  PCNA-interacting partner isoform X5

    3. XM_054372373.1 → XP_054228348.1  PCNA-interacting partner isoform X6

    4. XM_054372368.1 → XP_054228343.1  PCNA-interacting partner isoform X1

    5. XM_054372375.1 → XP_054228350.1  PCNA-interacting partner isoform X8

    6. XM_054372374.1 → XP_054228349.1  PCNA-interacting partner isoform X7

    7. XM_054372378.1 → XP_054228353.1  PCNA-interacting partner isoform X11

      UniProtKB/TrEMBL
      A0A0C4DG30

    8. XM_054372370.1 → XP_054228345.1  PCNA-interacting partner isoform X3

    9. XM_054372377.1 → XP_054228352.1  PCNA-interacting partner isoform X10

      UniProtKB/TrEMBL
      A0A0C4DG30

    10. XM_054372376.1 → XP_054228351.1  PCNA-interacting partner isoform X9

      UniProtKB/TrEMBL
      A0A0C4DG30

    11. XM_054372379.1 → XP_054228354.1  PCNA-interacting partner isoform X12

    12. XM_054372380.1 → XP_054228355.1  PCNA-interacting partner isoform X13

    13. XM_054372371.1 → XP_054228346.1  PCNA-interacting partner isoform X4

    RNA

    1. XR_008488627.1 RNA Sequence

    2. XR_008488628.1 RNA Sequence

    3. XR_008488629.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NWS1.3 GenPept UniProtKB/Swiss-Prot:Q9NWS1

    Gene LinkOut

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