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    UGT2A3 UDP glucuronosyltransferase family 2 member A3 [ Homo sapiens (human) ]

    Gene ID: 79799, updated on 27-Nov-2024

    Summary

    Official Symbol
    UGT2A3provided by HGNC
    Official Full Name
    UDP glucuronosyltransferase family 2 member A3provided by HGNC
    Primary source
    HGNC:HGNC:28528
    See related
    Ensembl:ENSG00000135220 MIM:616382; AllianceGenome:HGNC:28528
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables glucuronosyltransferase activity. Involved in cellular glucuronidation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in duodenum (RPKM 93.7), small intestine (RPKM 88.2) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See UGT2A3 in Genome Data Viewer
    Location:
    4q13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (68928463..68951804, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (72369135..72392453, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (69794181..69817522, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene UDP-glucuronosyltransferase 2B10-like Neighboring gene SPOPL pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:69769570-69770462 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:69771354-69772245 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:69772246-69773136 Neighboring gene uncharacterized LOC124900853 Neighboring gene UDP-glucuronosyltransferase 2B10-like Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:69795178-69796377 Neighboring gene UDP glucuronosyltransferase family 2 member A1 complex locus pseudogene Neighboring gene SPOPL pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21934

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glucuronosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glucuronosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular glucuronidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular glucuronidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    UDP-glucuronosyltransferase 2A3
    Names
    UDP glucuronosyltransferase 2 family, polypeptide A3
    UDPGT 2A3
    NP_079019.3
    XP_011530549.1
    XP_047272133.1
    XP_054184521.1
    XP_054184522.1
    XP_054206815.1
    XP_054206816.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024743.4NP_079019.3  UDP-glucuronosyltransferase 2A3 precursor

      See identical proteins and their annotated locations for NP_079019.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript.
      Source sequence(s)
      AC021146, AK025587, AY542891
      Consensus CDS
      CCDS3525.1
      UniProtKB/Swiss-Prot
      Q6UWM9, Q9H6S4
      Related
      ENSP00000251566.4, ENST00000251566.9
      Conserved Domains (2) summary
      PHA03392
      Location:267492
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:24522
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    RNA

    1. NR_024010.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate exon in the coding region, compared to variant 1, which results in the introduction of an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC021146, AK025587, AY542891, BP262099

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      68928463..68951804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532247.3XP_011530549.1  UDP-glucuronosyltransferase 2A3 isoform X1

      See identical proteins and their annotated locations for XP_011530549.1

      Conserved Domains (2) summary
      PHA03392
      Location:267498
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:24528
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
    2. XM_047416177.1XP_047272133.1  UDP-glucuronosyltransferase 2A3 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167250.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      504482..527823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328546.1XP_054184521.1  UDP-glucuronosyltransferase 2A3 isoform X1

    2. XM_054328547.1XP_054184522.1  UDP-glucuronosyltransferase 2A3 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      72369135..72392453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350840.1XP_054206815.1  UDP-glucuronosyltransferase 2A3 isoform X1

    2. XM_054350841.1XP_054206816.1  UDP-glucuronosyltransferase 2A3 isoform X2

      UniProtKB/TrEMBL
      B4DDY2