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    FBXO24 F-box protein 24 [ Homo sapiens (human) ]

    Gene ID: 26261, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FBXO24provided by HGNC
    Official Full Name
    F-box protein 24provided by HGNC
    Primary source
    HGNC:HGNC:13595
    See related
    Ensembl:ENSG00000106336 MIM:609097; AllianceGenome:HGNC:13595
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBX24
    Summary
    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
    Expression
    Restricted expression toward testis (RPKM 14.9) See more
    Orthologs
    mouse all
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    Genomic context

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    See FBXO24 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100586328..100601117)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101826411..101841198)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100183951..100198740)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100172387-100172941 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100172942-100173495 Neighboring gene Sin3A associated protein 25 Neighboring gene leucine rich repeats and calponin homology domain containing 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100181227-100181915 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100182061-100182574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100182575-100183088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18445 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18446 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100187581-100188381 Neighboring gene PCOLCE antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100201095-100201887 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26376 Neighboring gene procollagen C-endopeptidase enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18450 Neighboring gene motile sperm domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. FBXO24 Suppresses Breast Cancer Tumorigenesis by Targeting LSD1 for Ubiquitination. Dong B, et al. Mol Cancer Res, 2023 Dec 1. PMID 37540490, Free PMC Article
    2. SCF-FBXO24 regulates cell proliferation by mediating ubiquitination and degradation of PRMT6. Chen W, et al. Biochem Biophys Res Commun, 2020 Sep 10. PMID 32828318
    3. FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration. El-Mergawy R, et al. J Biol Chem, 2024 Jun. PMID 38735474, Free PMC Article
    4. The ubiquitin E3 ligase SCF-FBXO24 recognizes deacetylated nucleoside diphosphate kinase A to enhance its degradation. Chen W, et al. Mol Cell Biol, 2015 Mar. PMID 25582197, Free PMC Article
    5. FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and male fertility. Li Z, et al. Elife, 2024 Mar 12. PMID 38470475, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration.
      Title: FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration.
    2. FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and male fertility.
      Title: FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and male fertility.
    3. FBXO24 Suppresses Breast Cancer Tumorigenesis by Targeting LSD1 for Ubiquitination.
      Title: FBXO24 Suppresses Breast Cancer Tumorigenesis by Targeting LSD1 for Ubiquitination.
    4. SCF-FBXO24 regulates cell proliferation by mediating ubiquitination and degradation of PRMT6.
      Title: SCF-FBXO24 regulates cell proliferation by mediating ubiquitination and degradation of PRMT6.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp434I1122

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ubiquitin ligase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box only protein 24
    Names
    F-box protein Fbx24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163499.2 → NP_001156971.1  F-box only protein 24 isoform 4

      See identical proteins and their annotated locations for NP_001156971.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter, 5' UTR, and 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK302252, BC067293
      Consensus CDS
      CCDS55138.1
      UniProtKB/Swiss-Prot
      O75426
      Related
      ENSP00000420239.1, ENST00000468962.5
      Conserved Domains (2) summary
      pfam00415
      Location:364 → 410
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam12937
      Location:31 → 73
      F-box-like; F-box-like

    2. NM_012172.5 → NP_036304.2  F-box only protein 24 isoform 3

      See identical proteins and their annotated locations for NP_036304.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter, 5' UTR, and 5' coding region, compared to variant 1. The resulting isoform (3) has a longer and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK301864, BC067293, DC397982
      Consensus CDS
      CCDS5699.2
      UniProtKB/Swiss-Prot
      O75426
      Related
      ENSP00000416558.2, ENST00000427939.2
      Conserved Domains (2) summary
      pfam00415
      Location:414 → 460
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam12937
      Location:81 → 123
      F-box-like; F-box-like

    3. NM_033506.3 → NP_277041.1  F-box only protein 24 isoform 1

      See identical proteins and their annotated locations for NP_277041.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AC069281, BC067293, BU656991
      Consensus CDS
      CCDS5698.1
      UniProtKB/Swiss-Prot
      A4D2D4, B4DX91, B4DY42, O75426, Q9H0G1
      UniProtKB/TrEMBL
      A4D2D3
      Related
      ENSP00000241071.6, ENST00000241071.11
      Conserved Domains (2) summary
      pfam00415
      Location:376 → 422
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam12937
      Location:43 → 83
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      100586328..100601117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420182.1 → XP_047276138.1  F-box only protein 24 isoform X3

    2. XM_011516022.1 → XP_011514324.1  F-box only protein 24 isoform X1

      Conserved Domains (2) summary
      pfam00415
      Location:381 → 427
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam12937
      Location:48 → 90
      F-box-like; F-box-like

    3. XM_047420183.1 → XP_047276139.1  F-box only protein 24 isoform X4

    4. XM_005250259.5 → XP_005250316.1  F-box only protein 24 isoform X2

      Conserved Domains (2) summary
      pfam00415
      Location:414 → 442
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam12937
      Location:81 → 123
      F-box-like; F-box-like

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      101826411..101841198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357860.1 → XP_054213835.1  F-box only protein 24 isoform X3

    2. XM_054357858.1 → XP_054213833.1  F-box only protein 24 isoform X1

    3. XM_054357861.1 → XP_054213836.1  F-box only protein 24 isoform X4

    4. XM_054357859.1 → XP_054213834.1  F-box only protein 24 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75426.2 GenPept UniProtKB/Swiss-Prot:O75426

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