WT1 WT1 transcription factor [Homo sapiens (human)] - Gene

Summary

Official Symbol: WT1provided by HGNC
Official Full Name: WT1 transcription factorprovided by HGNC
Primary source: HGNC:HGNC:12796
See related: Ensembl:ENSG00000184937 MIM:607102; AllianceGenome:HGNC:12796
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GUD; AWT1; WAGR; WT-1; WT33; NPHS4; WIT-2
Summary: This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
Expression: Biased expression in endometrium (RPKM 27.6), testis (RPKM 17.6) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (32387775..32435539, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (32523264..32571024, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (32409321..32457085, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kidney Organoid Modeling of WT1 Mutations Reveals Key Regulatory Paths Underlying Podocyte Development.
Title: Kidney Organoid Modeling of WT1 Mutations Reveals Key Regulatory Paths Underlying Podocyte Development.
EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors.
Title: EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors.
Upregulation of HOXA3 by isoform-specific Wilms tumour 1 drives chemotherapy resistance in acute myeloid leukaemia.
Title: Upregulation of HOXA3 by isoform-specific Wilms tumour 1 drives chemotherapy resistance in acute myeloid leukaemia.
Homeobox regulator Wilms Tumour 1 is displaced by androgen receptor at cis-regulatory elements in the endometrium of PCOS patients.
Title: Homeobox regulator Wilms Tumour 1 is displaced by androgen receptor at cis-regulatory elements in the endometrium of PCOS patients.
Inhibition of transcriptional coactivator YAP Impairs the expression and function of transcription factor WT1 in diabetic podocyte injury.
Title: Inhibition of transcriptional coactivator YAP Impairs the expression and function of transcription factor WT1 in diabetic podocyte injury.
MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFbeta2-Smad2/3 signaling pathway in cervical cancer.
Title: MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFβ2-Smad2/3 signaling pathway in cervical cancer.
Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for Desmoplastic Small Round Cell Tumors.
Title: Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for Desmoplastic Small Round Cell Tumors.
Overexpression of WT1 in all molecular subtypes of breast cancer and its impact on survival: exploring oncogenic and tumor suppressor roles of distinct WT1 isoforms.
Title: Overexpression of WT1 in all molecular subtypes of breast cancer and its impact on survival: exploring oncogenic and tumor suppressor roles of distinct WT1 isoforms.
EWSR1::WT1 Fusions in Neoplasms Other Than Conventional Desmoplastic Small Round Cell Tumor: Three Tumors Occurring Outside the Female Genital Tract.
Title: EWSR1::WT1 Fusions in Neoplasms Other Than Conventional Desmoplastic Small Round Cell Tumor: Three Tumors Occurring Outside the Female Genital Tract.
WT1 and TP53 as valuable diagnostic biomarkers for relapse after hematopoietic stem cell transplantation in acute myeloid leukemia.
Title: WT1 and TP53 as valuable diagnostic biomarkers for relapse after hematopoietic stem cell transplantation in acute myeloid leukemia.

Submit: New GeneRIF Correction See all GeneRIFs (636)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Professional guidelines

Description
Professional guideline ACMG 2013 The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in WT1 that are pathogenic or expected to be pathogenic. GuidelinePubMed

Associated conditions

Description	Tests
11p partial monosomy syndrome MedGen: C0206115 OMIM: 194072 GeneReviews: PAX6-Related Aniridia	Compare labs
Aniridia 1 MedGen: C0344542 OMIM: 106210 GeneReviews: PAX6-Related Aniridia	Compare labs
Drash syndrome MedGen: C0950121 OMIM: 194080 GeneReviews: WT1 Disorder	Compare labs
Frasier syndrome MedGen: C0950122 OMIM: 136680 GeneReviews: WT1 Disorder	Compare labs
Meacham syndrome MedGen: C1837026 OMIM: 608978 GeneReviews: WT1 Disorder	Compare labs
Mesothelioma, malignant MedGen: C0345967 OMIM: 156240 GeneReviews: Not available	Compare labs
Nephrotic syndrome, type 4 MedGen: C3151568 OMIM: 256370 GeneReviews: WT1 Disorder	Compare labs
Wilms tumor 1 MedGen: CN033288 OMIM: 194070 GeneReviews: Wilms Tumor Predisposition, PAX6-Related Aniridia, WT1 Disorder	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2022-01-25) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2022-01-25) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Common variants at 11p13 are associated with susceptibility to tuberculosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies Wilms tumor 1 (WT1) is important for HIV-1 replication. shRNA against WT1 exhibits a decrease on LTR-driven beta-gal transcription compared to control	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	Podocyte-specific expression of HIV-1 Nef induces loss of synaptopodin and WT1, and expression of Ki-67 in podocytes, which is essential for the dedifferentiation and proliferation of podocytes in HIV-associated nephropathy	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G15888 (e-PCR)
- UniSTS:76811

GDB:313098 (e-PCR)
- UniSTS:156436

Wt1 (e-PCR), detects polymorphism
- UniSTS:265240

Wt1 (e-PCR), detects polymorphism
- UniSTS:464700

Wt1 (e-PCR), detects polymorphism
- UniSTS:464701

Wt1 (e-PCR), detects polymorphism
- UniSTS:464702

WT1 (e-PCR)
- UniSTS:75583

NoName (e-PCR)
- UniSTS:148287

GDB:568832 (e-PCR)
- UniSTS:157760

PMC20552P1 (e-PCR)
- UniSTS:271943

RH18097 (e-PCR)
- UniSTS:66123

GDB:512306 (e-PCR)
- UniSTS:157525

GDB:512315 (e-PCR)
- UniSTS:157526

GDB:595974 (e-PCR)
- UniSTS:158038

GDB:595983 (e-PCR)
- UniSTS:158039

GDB:595991 (e-PCR)
- UniSTS:158040

GDB:596004 (e-PCR)
- UniSTS:158041

GDB:596045 (e-PCR)
- UniSTS:158044

WT1_1108 (e-PCR)
- UniSTS:277864

GDB:186603 (e-PCR)
- UniSTS:155497

G59663 (e-PCR)
- UniSTS:136817

WT1-2 (e-PCR)
- UniSTS:254075

GDB:250580 (e-PCR)
- UniSTS:156292

GDB:250581 (e-PCR)
- UniSTS:156293

GDB:250582 (e-PCR)
- UniSTS:156294

GDB:250583 (e-PCR)
- UniSTS:156295

GDB:250584 (e-PCR)
- UniSTS:156296

GDB:250585 (e-PCR)
- UniSTS:156297

GDB:250586 (e-PCR)
- UniSTS:156298

GDB:316182 (e-PCR)
- UniSTS:156572

GDB:316186 (e-PCR)
- UniSTS:156574

GDB:178695 (e-PCR)
- UniSTS:155041

D11S3501 (e-PCR)
- UniSTS:152740

GDB:371622 (e-PCR)
- UniSTS:156867

GDB:371627 (e-PCR)
- UniSTS:156868

GDB:371630 (e-PCR)
- UniSTS:156869

GDB:371633 (e-PCR)
- UniSTS:156870

GDB:371636 (e-PCR)
- UniSTS:156871

GDB:371639 (e-PCR)
- UniSTS:156872

GDB:371642 (e-PCR)
- UniSTS:156873

GDB:371645 (e-PCR)
- UniSTS:156874

D11S813E (e-PCR)
- UniSTS:473035

GDB:371654 (e-PCR)
- UniSTS:156877

GDB:371660 (e-PCR)
- UniSTS:156879

GDB:371667 (e-PCR)
- UniSTS:156881

G54575 (e-PCR)
- UniSTS:117713

GDB:371670 (e-PCR)
- UniSTS:156882

GDB:371673 (e-PCR)
- UniSTS:156883

GDB:371676 (e-PCR)
- UniSTS:156884

GDB:371679 (e-PCR)
- UniSTS:156885

GDB:371682 (e-PCR)
- UniSTS:156886

GDB:371686 (e-PCR)
- UniSTS:156887

WT (e-PCR)
- UniSTS:253946

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables C2H2 zinc finger domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded methylated DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables hemi-methylated DNA-binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	ISS Inferred from Sequence or Structural Similarity more info
involved_in adrenal cortex formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in adrenal gland development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in branching involved in ureteric bud morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in camera-type eye development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle cell fate commitment	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to gonadotropin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in diaphragm development	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in germ cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in glomerular basement membrane development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glomerulus development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gonad development	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in kidney development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in male genitalia development	ISS Inferred from Sequence or Structural Similarity more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mesenchymal to epithelial transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric S-shaped body morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in metanephric epithelium development	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephric mesenchyme development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of female gonad development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_positive_effect negative regulation of gene expression via chromosomal CpG island methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of metanephric glomerular mesangial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in podocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heart growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of male gonad development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of metanephric ureteric bud development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of miRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in posterior mesonephric tubule development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of animal organ formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in sex determination	IDA Inferred from Direct Assay more info	PubMed
involved_in thorax and anterior abdomen determination	ISS Inferred from Sequence or Structural Similarity more info
involved_in tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in ureteric bud development	ISS Inferred from Sequence or Structural Similarity more info
involved_in vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in visceral serous pericardium development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Wilms tumor protein

Names: Wilms tumor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009272.1 RefSeqGene

Range

5001..52767

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_525

mRNA and Protein(s)

NM_000378.6 → NP_000369.4 Wilms tumor protein isoform A

Status: REVIEWED

Source sequence(s)

AB971668, AK093168, BC046461, M30393, X51630

Consensus CDS

CCDS44561.2

UniProtKB/TrEMBL

A0A1W2PQQ0, J3KNN9

Related

ENSP00000331327.5, ENST00000332351.9

Conserved Domains (3) summary

COG5048
Location:437 → 495

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:384 → 403

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam02165
Location:74 → 377

WT1; Wilm's tumor protein
NM_001198551.2 → NP_001185480.1 Wilms tumor protein isoform E

See identical proteins and their annotated locations for NP_001185480.1

Status: REVIEWED

Source sequence(s)

AL049692

Consensus CDS

CCDS55751.1

UniProtKB/TrEMBL

A0A1W2PR07

Related

ENSP00000368370.2, ENST00000379079.8

Conserved Domains (3) summary

COG5048
Location:237 → 295

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:184 → 203

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam02165
Location:3 → 177

WT1; Wilm's tumor protein
NM_001198552.2 → NP_001185481.1 Wilms tumor protein isoform F

See identical proteins and their annotated locations for NP_001185481.1

Status: REVIEWED

Source sequence(s)

AK093168, BC046461, BG718348, M30393

Consensus CDS

CCDS55750.1

UniProtKB/TrEMBL

A0A1W2PR07

Related

ENSP00000435307.1, ENST00000530998.5

Conserved Domains (3) summary

COG5048
Location:152 → 280

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:167 → 186

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam02165
Location:3 → 160

WT1; Wilm's tumor protein
NM_001367854.1 → NP_001354783.1 Wilms tumor protein isoform G

Status: REVIEWED

Source sequence(s)

AL049692

Related

ENST00000652724.1

Conserved Domains (2) summary

COG5048
Location:5 → 118

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:5 → 24

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001407044.1 → NP_001393973.1 Wilms tumor protein isoform H

Status: REVIEWED

Source sequence(s)

AL049692

UniProtKB/TrEMBL

A0A0A0MT54
NM_001407045.1 → NP_001393974.1 Wilms tumor protein isoform I

Status: REVIEWED

Source sequence(s)

AL049692

UniProtKB/TrEMBL

A0A1W2PQQ0

Related

ENSP00000492269.3, ENST00000639563.4
NM_001407046.1 → NP_001393975.1 Wilms tumor protein isoform J

Status: REVIEWED

Source sequence(s)

AL049692

UniProtKB/TrEMBL

A0A0A0MT54

Related

ENSP00000498574.3, ENST00000651459.3
NM_001407047.1 → NP_001393976.1 Wilms tumor protein isoform K

Status: REVIEWED

Source sequence(s)

AL049692

UniProtKB/TrEMBL

A0A0A0MT54
NM_001407048.1 → NP_001393977.1 Wilms tumor protein isoform L

Status: REVIEWED

Source sequence(s)

AL049692

UniProtKB/TrEMBL

A0A1W2PQQ0
NM_001407049.1 → NP_001393978.1 Wilms tumor protein isoform M

Status: REVIEWED

Source sequence(s)

AL049692

UniProtKB/TrEMBL

A0A1W2PQQ0
NM_001407050.1 → NP_001393979.1 Wilms tumor protein isoform N

Status: REVIEWED

Source sequence(s)

AL049692

UniProtKB/TrEMBL

A0A1W2PQQ0
NM_001407051.1 → NP_001393980.1 Wilms tumor protein isoform O

Status: REVIEWED

Source sequence(s)

AL049692

UniProtKB/TrEMBL

A0A1W2PR07
NM_001429031.1 → NP_001415960.1 Wilms tumor protein isoform P

Status: REVIEWED

Source sequence(s)

AL049692

UniProtKB/Swiss-Prot

A8K6S1, B3KSA5, P19544, Q15881, Q16256, Q16575, Q4VXV4, Q4VXV5, Q4VXV6, Q8IYZ5

UniProtKB/TrEMBL

A0A0A0MT54, A0A481V744
NM_001429032.1 → NP_001415961.1 Wilms tumor protein isoform Q

Status: REVIEWED

Source sequence(s)

AL049692

UniProtKB/TrEMBL

A0A0A0MT54

Related

ENSP00000520896.1, ENST00000850608.1
NM_001429033.1 → NP_001415962.1 Wilms tumor protein isoform R

Status: REVIEWED

Source sequence(s)

AL049692

UniProtKB/TrEMBL

A0A1W2PQQ0

Related

ENSP00000520897.1, ENST00000850609.1
NM_001429034.1 → NP_001415963.1 Wilms tumor protein isoform S

Status: REVIEWED

Source sequence(s)

AL049692

UniProtKB/TrEMBL

A0A1W2PQQ0

Related

ENSP00000520898.1, ENST00000850610.1
NM_024424.5 → NP_077742.3 Wilms tumor protein isoform B

Status: REVIEWED

Source sequence(s)

AB971668, AK093168, AK291736, BC046461, M30393, X51630

Consensus CDS

CCDS44562.2

UniProtKB/TrEMBL

A0A0A0MT54, H0Y7K5

Related

ENSP00000413452.5, ENST00000448076.9

Conserved Domains (3) summary

COG5048
Location:454 → 512

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:401 → 420

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam02165
Location:74 → 394

WT1; Wilm's tumor protein
NM_024426.6 → NP_077744.4 Wilms tumor protein isoform D

Status: REVIEWED

Source sequence(s)

AB971668, AK093168, BC046461, M30393, X51630

Consensus CDS

CCDS7878.3

UniProtKB/TrEMBL

A0A0A0MT54

Related

ENSP00000415516.5, ENST00000452863.10

Conserved Domains (3) summary

COG5048
Location:386 → 514

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:401 → 420

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam02165
Location:74 → 394

WT1; Wilm's tumor protein

RNA

NR_160306.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AB971668, AL049692

Related

ENST00000379077.9
NR_176266.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL049692