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    SLC45A3 solute carrier family 45 member 3 [ Homo sapiens (human) ]

    Gene ID: 85414, updated on 27-Nov-2024

    Summary

    Official Symbol
    SLC45A3provided by HGNC
    Official Full Name
    solute carrier family 45 member 3provided by HGNC
    Primary source
    HGNC:HGNC:8642
    See related
    Ensembl:ENSG00000158715 MIM:605097; AllianceGenome:HGNC:8642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRST; IPCA6; IPCA-2; IPCA-6; IPCA-8; PCANAP2; PCANAP6; PCANAP8
    Summary
    Predicted to enable sucrose:proton symporter activity. Predicted to be involved in positive regulation of small molecule metabolic process; regulation of oligodendrocyte differentiation; and sucrose transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in prostate (RPKM 193.8) and stomach (RPKM 8.4) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC45A3 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (205657851..205680509, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (204922486..204945157, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (205626979..205649637, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 4A Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:205569093-205570292 Neighboring gene RNA, U6 small nuclear 418, pseudogene Neighboring gene GABA type A receptor-associated protein pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2383 Neighboring gene ETS transcription factor ELK4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2384 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2385 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205629205-205629793 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205631113-205631667 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205631668-205632223 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:205633133-205634332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2387 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205639145-205639706 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205644516-205645016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205645017-205645517 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1747 Neighboring gene uncharacterized LOC105371701 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205657475-205658431 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205662277-205662826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205670015-205670516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205670517-205671016 Neighboring gene nuclear casein kinase and cyclin dependent kinase substrate 1 Neighboring gene small nucleolar RNA SNORA72 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205708952-205709557 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205709558-205710164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205711268-205711871 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205711872-205712474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2389 Neighboring gene RAB29, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study of serum levels of prostate-specific antigen in the Japanese population.
    EBI GWAS Catalog
    Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies.
    EBI GWAS Catalog
    Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.
    EBI GWAS Catalog
    Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
    EBI GWAS Catalog
    Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: ELK4

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables sucrose:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sucrose:proton symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables sugar transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in hexose transmembrane transport TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of oligodendrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sucrose transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    solute carrier family 45 member 3
    Names
    prostate cancer associated protein 2
    prostate cancer associated protein 6
    prostate cancer associated protein 8
    prostate cancer-associated gene 2
    prostate cancer-associated gene 6
    prostate cancer-associated gene 8
    prostein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033102.3NP_149093.1  solute carrier family 45 member 3

      See identical proteins and their annotated locations for NP_149093.1

      Status: VALIDATED

      Source sequence(s)
      AC096533, BC050416, DA759616
      Consensus CDS
      CCDS1458.1
      UniProtKB/Swiss-Prot
      A8K2U9, Q96JT2
      Related
      ENSP00000356113.3, ENST00000367145.4
      Conserved Domains (1) summary
      TIGR01301
      Location:18350
      GPH_sucrose; GPH family sucrose/H+ symporter

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      205657851..205680509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      204922486..204945157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)