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    PDE1C phosphodiesterase 1C [ Homo sapiens (human) ]

    Gene ID: 5137, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PDE1Cprovided by HGNC
    Official Full Name
    phosphodiesterase 1Cprovided by HGNC
    Primary source
    HGNC:HGNC:8776
    See related
    Ensembl:ENSG00000154678 MIM:602987; AllianceGenome:HGNC:8776
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Hcam3; DFNA74; hCam-3; cam-PDE 1C
    Summary
    This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in heart (RPKM 9.1), brain (RPKM 4.0) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PDE1C in Genome Data Viewer
    Location:
    7p14.3
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (31616777..32428224, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (31754475..32567499, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (31790793..32467836, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs297 Neighboring gene NANOG hESC enhancer GRCh37_chr7:31411185-31411804 Neighboring gene uncharacterized LOC105375224 Neighboring gene neuronal differentiation 6 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:31505615-31506326 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:31506327-31507037 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:31517206-31518405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25823 Neighboring gene ITPR interacting domain containing 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:31690801-31691359 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:31749869-31750495 Neighboring gene protein phosphatase 1 regulatory subunit 17 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:31807284-31808218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25824 Neighboring gene NANOG hESC enhancer GRCh37_chr7:31865149-31865650 Neighboring gene Sharpr-MPRA regulatory region 14950 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:31977838-31979037 Neighboring gene sorting nexin 2 pseudogene 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:32202217-32203416 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:32244753-32245952 Neighboring gene MPRA-validated peak6468 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:32467257-32468070 Neighboring gene NANOG hESC enhancer GRCh37_chr7:32486745-32487256 Neighboring gene phosphoribosyl pyrophosphate synthetase 2 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:32503825-32504417 Neighboring gene solute carrier family 25 member 5 pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Subcellular localization and regulation of type-1C and type-5 phosphodiesterases. Dolci S, et al. Biochem Biophys Res Commun, 2006 Mar 17. PMID 16455054
    2. Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation. Rybalkin SD, et al. Circ Res, 2002 Feb 8. PMID 11834707
    3. Phosphodiesterase 1C integrates store-operated calcium entry and cAMP signaling in leading-edge protrusions of migrating human arterial myocytes. Brzezinska P, et al. J Biol Chem, 2021 Jan-Jun. PMID 33789162, Free PMC Article
    4. Cyclic nucleotide phosphodiesterase-1C (PDE1C) drives cell proliferation, migration and invasion in glioblastoma multiforme cells in vitro. Rowther FB, et al. Mol Carcinog, 2016 Mar. PMID 25620587
    5. Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm. Zhang C, et al. Proc Natl Acad Sci U S A, 2021 Aug 3. PMID 34312235, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm.
      Title: Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm.
    2. Phosphodiesterase 1C integrates store-operated calcium entry and cAMP signaling in leading-edge protrusions of migrating human arterial myocytes.
      Title: Phosphodiesterase 1C integrates store-operated calcium entry and cAMP signaling in leading-edge protrusions of migrating human arterial myocytes.
    3. By combining population-specific mutation arrays, targeted deafness genes panel, whole exome sequencing (WES), we identified PDE1C (Phosphodiesterase 1C) c.958G>T (p.A320S) as the disease-associated variant. Structural modeling insights into p.A320S strongly suggest that the sequence alteration will likely affect the substrate-binding pocket of PDE1C.
      Title: A dominant variant in the PDE1C gene is associated with nonsyndromic hearing loss.
    4. PDE1C is a proliferation-associated gene in glioblastoma multiforme cells in vitro.
      Title: Cyclic nucleotide phosphodiesterase-1C (PDE1C) drives cell proliferation, migration and invasion in glioblastoma multiforme cells in vitro.
    5. PDE1C is an important regulator of SMC proliferation, migration, and neointimal hyperplasia, in part through modulating endosome/lysosome-dependent PDGFRbeta protein degradation via low-density lipoprotein receptor-related protein-1.
      Title: Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    7. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    9. PDE1C1 is expressed at high levels in human cardiac myocytes with an intracellular distribution distinct from that of PDE3A
      Title: Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes.
    10. PDE1C levels decreased in all conditions that inhibited proliferation
      Title: Subcellular localization and regulation of type-1C and type-5 phosphodiesterases.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Hearing loss, autosomal dominant 74
    MedGen: C4748334 OMIM: 618140 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Genome-wide association study link novel loci to endometriosis.
    EBI GWAS Catalog
    Genome-wide association study of antiphospholipid antibodies.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
    Names
    3',5'-cyclic-AMP phosphodiesterase
    3',5'-cyclic-GMP phosphodiesterase
    Human 3',5' cyclic nucleotide phosphodiesterase (HSPDE1C1A)
    calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
    dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
    phosphodiesterase 1C, calmodulin-dependent 70kDa
    NP_001177985.1
    NP_001177986.1
    NP_001177987.2
    NP_001177988.1
    NP_001308984.1
    NP_001308985.1
    NP_001308986.1
    NP_001308987.1
    NP_001308988.1
    NP_005011.1
    XP_016867753.1
    XP_016867754.1
    XP_016867755.1
    XP_016867756.1
    XP_047276396.1
    XP_047276397.1
    XP_047276398.1
    XP_047276399.1
    XP_047276400.1
    XP_047276401.1
    XP_047276402.1
    XP_054214305.1
    XP_054214306.1
    XP_054214307.1
    XP_054214308.1
    XP_054214309.1
    XP_054214310.1
    XP_054214311.1
    XP_054214312.1
    XP_054214313.1
    XP_054214314.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051183.2 RefSeqGene

      Range
      362817..682045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001191056.3 → NP_001177985.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 1

      See identical proteins and their annotated locations for NP_001177985.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' and 3' UTR and has multiple coding region differences, compared to variant 3. These differences result in an isoform (1) with distinct N- and C-termini, compared to isoform 3. Variants 1 and 4 encode the same protein. Isoform 1 is also known as HCam-3B.
      Source sequence(s)
      AC004931, AC006377, AK056170, AK125029, BM668260, U40371
      Consensus CDS
      CCDS5437.1
      UniProtKB/TrEMBL
      Q8TAE4
      Related
      ENSP00000379485.2, ENST00000396182.6
      Conserved Domains (2) summary
      pfam00233
      Location:227 → 445
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:86 → 142
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    2. NM_001191057.4 → NP_001177986.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2

      See identical proteins and their annotated locations for NP_001177986.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 3. These differences result in an isoform (2) with a distinct N-terminus, compared to isoform 3. Variants 2 and 5 encode the same protein. Isoform 2 is also known as HCam-3A.
      Source sequence(s)
      AC006377, AC007093, AI168057, AI301181, AK056170, CB135276, HY125708
      Consensus CDS
      CCDS55099.1
      UniProtKB/Swiss-Prot
      B3KPC6, E9PE92, Q14123, Q14124, Q8NB10
      UniProtKB/TrEMBL
      B3KSS6
      Related
      ENSP00000379494.1, ENST00000396191.6
      Conserved Domains (2) summary
      pfam00233
      Location:227 → 455
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:86 → 142
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    3. NM_001191058.4 → NP_001177987.2  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3). Variants 3 and 10 encode isoforms that are the same length, but have distinct protein sequences.
      Source sequence(s)
      AC006377, AC007093, AC018637, AI168057, AI301181, AK056170, AK091734, CB135276, HY125708
      Consensus CDS
      CCDS55100.1
      UniProtKB/TrEMBL
      A0A0A0MS69, B3KSS6
      Related
      ENSP00000379496.1, ENST00000396193.5
      Conserved Domains (2) summary
      pfam00233
      Location:287 → 515
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:142 → 202
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    4. NM_001191059.4 → NP_001177988.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2

      See identical proteins and their annotated locations for NP_001177988.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 3. These differences result in an isoform (2) with a distinct N-terminus, compared to isoform 3. Variants 2 and 5 encode the same protein. Isoform 2 is also known as HCam-3A.
      Source sequence(s)
      AC006377, AC007093, AI168057, AI301181, AK056170, CB135276, DA023468, HY125708
      Consensus CDS
      CCDS55099.1
      UniProtKB/Swiss-Prot
      B3KPC6, E9PE92, Q14123, Q14124, Q8NB10
      UniProtKB/TrEMBL
      B3KSS6
      Related
      ENSP00000318105.7, ENST00000321453.12
      Conserved Domains (2) summary
      pfam00233
      Location:227 → 455
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:86 → 142
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    5. NM_001322055.2 → NP_001308984.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC004931, AC006377, AC007093, AI168057, AI301181, AK056170, CB135276, DA174241, DA231237, HY125708
      Consensus CDS
      CCDS55099.1
      UniProtKB/Swiss-Prot
      B3KPC6, E9PE92, Q14123, Q14124, Q8NB10
      UniProtKB/TrEMBL
      B3KSS6
      Conserved Domains (2) summary
      pfam00233
      Location:227 → 455
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:86 → 142
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    6. NM_001322056.2 → NP_001308985.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC004931, AC006377
      Consensus CDS
      CCDS5437.1
      UniProtKB/TrEMBL
      Q8TAE4
      Conserved Domains (2) summary
      pfam00233
      Location:227 → 445
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:86 → 142
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    7. NM_001322057.2 → NP_001308986.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC004931, AC006377
      Consensus CDS
      CCDS5437.1
      UniProtKB/TrEMBL
      Q8TAE4
      Conserved Domains (2) summary
      pfam00233
      Location:227 → 445
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:86 → 142
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    8. NM_001322058.2 → NP_001308987.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC005589, AC006377, AC018637, KF458425
      UniProtKB/TrEMBL
      Q75MP2
      Conserved Domains (2) summary
      pfam00233
      Location:287 → 505
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:146 → 202
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    9. NM_001322059.2 → NP_001308988.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: Variants 3 and 10 encode isoforms that are the same length, but have distinct protein sequences.
      Source sequence(s)
      AC005589, AC006377, AC018637, KF458425
      UniProtKB/Swiss-Prot
      Q14123
      Conserved Domains (2) summary
      pfam00233
      Location:362 → 590
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:221 → 277
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    10. NM_005020.5 → NP_005011.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 1

      See identical proteins and their annotated locations for NP_005011.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' and 3' UTR and has multiple coding region differences, compared to variant 3. These differences result in an isoform (1) with distinct N- and C-termini, compared to isoform 3. Variants 1 and 4 encode the same protein. Isoform 1 is also known as HCam-3B.
      Source sequence(s)
      AC004931, AC006377
      Consensus CDS
      CCDS5437.1
      UniProtKB/TrEMBL
      Q8TAE4
      Related
      ENSP00000379487.3, ENST00000396184.7
      Conserved Domains (2) summary
      pfam00233
      Location:227 → 445
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:86 → 142
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      31616777..32428224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420443.1 → XP_047276399.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

      UniProtKB/TrEMBL
      Q8TAE4

    2. XM_047420442.1 → XP_047276398.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

      UniProtKB/TrEMBL
      Q8TAE4

    3. XM_047420441.1 → XP_047276397.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

      UniProtKB/TrEMBL
      Q8TAE4

    4. XM_017012264.1 → XP_016867753.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1

      UniProtKB/TrEMBL
      B3KSS6

    5. XM_017012265.1 → XP_016867754.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2

      UniProtKB/TrEMBL
      B3KSS6

    6. XM_047420440.1 → XP_047276396.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4

      UniProtKB/Swiss-Prot
      B3KPC6, E9PE92, Q14123, Q14124, Q8NB10
      UniProtKB/TrEMBL
      B3KSS6

    7. XM_017012267.2 → XP_016867756.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4

      UniProtKB/Swiss-Prot
      B3KPC6, E9PE92, Q14123, Q14124, Q8NB10
      UniProtKB/TrEMBL
      B3KSS6
      Conserved Domains (2) summary
      pfam00233
      Location:227 → 455
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:86 → 142
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    8. XM_047420445.1 → XP_047276401.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X7

      UniProtKB/TrEMBL
      B3KSS6

    9. XM_017012266.2 → XP_016867755.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X3

      UniProtKB/TrEMBL
      Q75MP2

    10. XM_047420444.1 → XP_047276400.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X6

      UniProtKB/TrEMBL
      Q8TAE4

    11. XM_047420446.1 → XP_047276402.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X8

      UniProtKB/TrEMBL
      Q75MP2

    RNA

    1. XR_001744802.1 RNA Sequence

    2. XR_001744803.1 RNA Sequence

    3. XR_007060044.1 RNA Sequence

    4. XR_007060042.1 RNA Sequence

    5. XR_007060043.1 RNA Sequence

    6. XR_007060041.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      31754475..32567499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358337.1 → XP_054214312.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

      UniProtKB/TrEMBL
      Q8TAE4

    2. XM_054358336.1 → XP_054214311.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

      UniProtKB/TrEMBL
      Q8TAE4

    3. XM_054358335.1 → XP_054214310.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

      UniProtKB/TrEMBL
      Q8TAE4

    4. XM_054358330.1 → XP_054214305.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1

      UniProtKB/TrEMBL
      B3KSS6

    5. XM_054358331.1 → XP_054214306.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2

      UniProtKB/TrEMBL
      B3KSS6

    6. XM_054358333.1 → XP_054214308.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4

      UniProtKB/Swiss-Prot
      B3KPC6, E9PE92, Q14123, Q14124, Q8NB10
      UniProtKB/TrEMBL
      B3KSS6

    7. XM_054358334.1 → XP_054214309.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4

      UniProtKB/Swiss-Prot
      B3KPC6, E9PE92, Q14123, Q14124, Q8NB10
      UniProtKB/TrEMBL
      B3KSS6

    8. XM_054358332.1 → XP_054214307.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X3

      UniProtKB/TrEMBL
      Q75MP2

    9. XM_054358338.1 → XP_054214313.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X6

      UniProtKB/TrEMBL
      Q8TAE4

    10. XM_054358339.1 → XP_054214314.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X8

      UniProtKB/TrEMBL
      Q75MP2

    RNA

    1. XR_008487624.1 RNA Sequence

    2. XR_008487625.1 RNA Sequence

    3. XR_008487629.1 RNA Sequence

    4. XR_008487627.1 RNA Sequence

    5. XR_008487628.1 RNA Sequence

    6. XR_008487626.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14123.1 GenPept UniProtKB/Swiss-Prot:Q14123

    Gene LinkOut

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