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    STK17B serine/threonine kinase 17b [ Homo sapiens (human) ]

    Gene ID: 9262, updated on 9-Dec-2024

    Summary

    Official Symbol
    STK17Bprovided by HGNC
    Official Full Name
    serine/threonine kinase 17bprovided by HGNC
    Primary source
    HGNC:HGNC:11396
    See related
    Ensembl:ENSG00000081320 MIM:604727; AllianceGenome:HGNC:11396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRAK2
    Summary
    Enables ATP binding activity and protein serine/threonine kinase activity. Involved in intracellular signal transduction; positive regulation of fibroblast apoptotic process; and protein phosphorylation. Located in Flemming body and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bone marrow (RPKM 54.0), lymph node (RPKM 45.0) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See STK17B in Genome Data Viewer
    Location:
    2q32.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (196133583..196176483, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (196617655..196666801, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (196998307..197036302, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 7 Neighboring gene E2F transcription factor 3 pseudogene 2 Neighboring gene glutathione S-transferase alpha 5 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16892 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:196961660-196962248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16895 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:196977894-196978422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:197023734-197024234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16896 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12202 Neighboring gene uncharacterized LOC101927454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16899 Neighboring gene small nucleolar RNA U13 Neighboring gene MPRA-validated peak4000 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16900 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:197124217-197125416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16901 Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene HECW2 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of fibroblast apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Flemming body IDA
    Inferred from Direct Assay
    more info
     
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase 17B
    Names
    DAP kinase-related apoptosis-inducing protein kinase 2
    death-associated protein kinase-related 2
    NP_004217.1
    XP_011510471.1
    XP_011510472.1
    XP_011510473.1
    XP_047302289.1
    XP_047302290.1
    XP_047302291.1
    XP_054200533.1
    XP_054200534.1
    XP_054200535.1
    XP_054200536.1
    XP_054200537.1
    XP_054200538.1
    XP_054200539.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004226.4NP_004217.1  serine/threonine-protein kinase 17B

      See identical proteins and their annotated locations for NP_004217.1

      Status: VALIDATED

      Source sequence(s)
      AC114760, BM994696
      Consensus CDS
      CCDS2315.1
      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98
      Related
      ENSP00000263955.4, ENST00000263955.9
      Conserved Domains (1) summary
      cd14198
      Location:24293
      STKc_DRAK2; The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      196133583..196176483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512169.2XP_011510471.1  serine/threonine-protein kinase 17B isoform X1

      See identical proteins and their annotated locations for XP_011510471.1

      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98
      Related
      ENSP00000386853.1, ENST00000409228.5
      Conserved Domains (1) summary
      cd14198
      Location:24293
      STKc_DRAK2; The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2
    2. XM_011512170.2XP_011510472.1  serine/threonine-protein kinase 17B isoform X1

      See identical proteins and their annotated locations for XP_011510472.1

      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98
      Related
      ENSP00000399755.2, ENST00000420683.2
      Conserved Domains (1) summary
      cd14198
      Location:24293
      STKc_DRAK2; The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2
    3. XM_047446334.1XP_047302290.1  serine/threonine-protein kinase 17B isoform X1

      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98
    4. XM_047446333.1XP_047302289.1  serine/threonine-protein kinase 17B isoform X1

      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98
      Related
      ENSP00000413289.2, ENST00000449152.2
    5. XM_011512171.3XP_011510473.1  serine/threonine-protein kinase 17B isoform X2

      See identical proteins and their annotated locations for XP_011510473.1

      Conserved Domains (2) summary
      smart00220
      Location:3165
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1165
      PKc_like; Protein Kinases, catalytic domain
    6. XM_047446335.1XP_047302291.1  serine/threonine-protein kinase 17B isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      196617655..196666801 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344561.1XP_054200536.1  serine/threonine-protein kinase 17B isoform X1

      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98
    2. XM_054344559.1XP_054200534.1  serine/threonine-protein kinase 17B isoform X1

      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98
    3. XM_054344560.1XP_054200535.1  serine/threonine-protein kinase 17B isoform X1

      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98
    4. XM_054344562.1XP_054200537.1  serine/threonine-protein kinase 17B isoform X1

      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98
    5. XM_054344558.1XP_054200533.1  serine/threonine-protein kinase 17B isoform X1

      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98
    6. XM_054344563.1XP_054200538.1  serine/threonine-protein kinase 17B isoform X2

    7. XM_054344564.1XP_054200539.1  serine/threonine-protein kinase 17B isoform X2