XPOT exportin for tRNA [Homo sapiens (human)] - Gene

Summary

Official Symbol: XPOTprovided by HGNC
Official Full Name: exportin for tRNAprovided by HGNC
Primary source: HGNC:HGNC:12826
See related: Ensembl:ENSG00000184575 MIM:603180; AllianceGenome:HGNC:12826
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: XPO3
Summary: This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in thyroid (RPKM 36.4), brain (RPKM 13.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q14.2

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (64404392..64451125)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (64382995..64429752)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (64798172..64844905)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

XPOT Disruption Suppresses TNBC Growth through Inhibition of Specific tRNA Nuclear Exportation and TTC19 Expression to Induce Cytokinesis Failure.
Title: XPOT Disruption Suppresses TNBC Growth through Inhibition of Specific tRNA Nuclear Exportation and TTC19 Expression to Induce Cytokinesis Failure.
Exportin-T: A Novel Prognostic Predictor and Potential Therapeutic Target for Neuroblastoma.
Title: Exportin-T: A Novel Prognostic Predictor and Potential Therapeutic Target for Neuroblastoma.
Results indicated that hepatocellular carcinoma (HCC) patients with high XPOT expression level had poor prognosis. XPOT promotes tumor proliferation and invasion in HCC and may affect the tumor cell cycle through ubiquitin-mediated proteolysis.
Title: Exportin-T promotes tumor proliferation and invasion in hepatocellular carcinoma.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Exportin-t preferentially binds and exports those tRNAs that are rapidly consumed by the protein synthesis machinery.
Title: Interaction of immobilized human exportin-t with calf liver tRNA.
Results suggest that decreased expression of exportin-1 and exportin-t induced by 1alpha,25-dihydroxyvitamin D3 can be correlated to inhibition of the proliferation of HL-60 cells.
Title: 1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	Exportin-t-mediated nuclear-cytoplasmic transport of the eEF1A/Nef complexes in monocyte-derived macrophages is invloved in the inhibition of apoptosis triggered by stress	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G17621 (e-PCR)
- UniSTS:44823

G20240 (e-PCR)
- UniSTS:37729

D12S1146E (e-PCR)
- UniSTS:57538

RH16726 (e-PCR)
- UniSTS:87786

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in tRNA export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA re-export from nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nuclear matrix	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: exportin-T

Names: exportin(tRNA); exportin, tRNA (nuclear export receptor for tRNAs); tRNA exportin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007235.6 → NP_009166.2 exportin-T

See identical proteins and their annotated locations for NP_009166.2

Status: REVIEWED

Source sequence(s)

AC135279, AK292884, BC020569, CR979468

Consensus CDS

CCDS31852.1

UniProtKB/Swiss-Prot

A6NLH1, O43592, O43784, Q8WUG2, Q9BVS7

UniProtKB/TrEMBL

A8KA19

Related

ENSP00000327821.5, ENST00000332707.10

Conserved Domains (2) summary

smart00913
Location:21 → 88

IBN_N; Importin-beta N-terminal domain

pfam08389
Location:100 → 247

Xpo1; Exportin 1-like protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

64404392..64451125

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047428193.1 → XP_047284149.1 exportin-T isoform X1

UniProtKB/Swiss-Prot

A6NLH1, O43592, O43784, Q8WUG2, Q9BVS7
XM_017018748.2 → XP_016874237.1 exportin-T isoform X1

UniProtKB/Swiss-Prot

A6NLH1, O43592, O43784, Q8WUG2, Q9BVS7

UniProtKB/TrEMBL

A8KA19

Conserved Domains (2) summary

smart00913
Location:21 → 88

IBN_N; Importin-beta N-terminal domain

pfam08389
Location:100 → 247

Xpo1; Exportin 1-like protein
XM_047428194.1 → XP_047284150.1 exportin-T isoform X2
XM_047428195.1 → XP_047284151.1 exportin-T isoform X3